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GENE：PLAU

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLAU
FullNmae plasminogen activator, urokinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9052
EnsembleID ENSG00000122861
Uniprot P00749

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLAU mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLAU autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLAU GO:0001666,GO:0004252,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005886,GO:0005925,GO:0006508,GO:0006935,GO:0007165,GO:0007596,GO:0009897,GO:0009986,GO:0010469,GO:0010755,GO:0010757,GO:0014909,GO:0014910,GO:0030155,GO:0030335,GO:0031639,GO:0031639,GO:0033628,GO:0033628,GO:0035579,GO:0038195,GO:0042127,GO:0042730,GO:0042730,GO:0051917,GO:0051918,GO:0061041,GO:0070062,GO:0070821,GO:0097180,GO:0098637,GO:1905370,GO:2000097

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLAU hsa:5328 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
PLAU hsa:5328 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
PLAU hsa:5328 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
PLAU hsa:5328 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PLAU hsa:5328 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PLAU hsa:5328 path:hsa05215 Prostate cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JAK1 PLAU 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAU PLAUR 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAU PLG 18633355 20027185 22470492 26192618 27216177 interaction type N/A ACSN
PLAU ITGB5 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAU ITGB1 18633355 22470492 26192618 27216177 interaction type N/A ACSN
FAP PLAU 21051638 23402812 24778314 25593080 26192618 27216177 7911242 interaction type N/A ACSN
SERPINE1 PLAU 11021826 20027185 25502501 26192618 interaction type N/A ACSN
EGF PLAU 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 26192618 8101258 interaction type N/A ACSN
FGF2 PLAU 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 26192618 9242465 interaction type N/A ACSN
PKNOX1 PLAU 23180781 9482740 physical association electrophoretic mobility supershift assay InnateDB
PLAU PBX1 23180781 9482740 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR PLAU 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA2 PLAU 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PLAU 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RELA PLAU 11689575 17407600 18226221 20018891 20352621 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 PLAU 10361124 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TFAP2C PLAU 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PLAU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PLAU 18971253 21283769 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PLAU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PLAU 11774399 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PLAU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PLAU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PLAU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PLAU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 PLAU 10454570 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 PLAU 18829529 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PLAU 11776974 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PLAU 10211993 11556732 trascriptional regulation,stimulation inferred by curator TFlink
GATA6 PLAU 15231498 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A PLAU 14567996 trascriptional regulation,stimulation inferred by curator TFlink
HOXD3 PLAU 14610084 trascriptional regulation,stimulation inferred by curator TFlink
ILF3 PLAU 22986534 trascriptional regulation,stimulation inferred by curator TFlink
JUN PLAU 10454570 11774399 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PLAU 11689575 17407600 20352621 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 PLAU 10951201 trascriptional regulation,stimulation inferred by curator TFlink
RARA PLAU 10361124 trascriptional regulation,stimulation inferred by curator TFlink
COP1 PLAU 12615916 trascriptional regulation,stimulation inferred by curator TFlink
RUNX2 PLAU 18331818 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PLAU 10361124 trascriptional regulation,stimulation inferred by curator TFlink
SRF PLAU 15514113 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PLAU N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 PLAU N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F3 PLAU N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 PLAU N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 PLAU N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 PLAU 19701247 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000183BED PLAU 19490101 21242962 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000183BED PLAU 19490101 21242962 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 PLAU 19701247 22473208 23372348 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 PLAU 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PLAU 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000006FDD4 PLAU 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 PLAU 22473208 25416803 27307030 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA PLAU 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MOCOS PLAU 25348397 N/A physical interaction ComPPI
CEBPG PLAU 25348397 N/A physical interaction ComPPI
BTK PLAU 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SERPINE1 PLAU 14525934 2161846 22449964 24234451 25348397 2544876 3090045 N/A experimental interaction detection,physical interaction,comigration in gel electrophoresis ComPPI,HPRD,IntAct
PLAT PLAU 14525934 25348397 7721771 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SERPINA5 PLAU 14525934 25348397 2551064 2752144 27898060 9365930 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
SERPINB2 PLAU 14525934 2161846 2166055 25348397 27898060 8388810 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PLAUR PLAU 11501527 14525934 24234451 24457100 25348397 3023326 3031025 physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction ComPPI,HPRD,IntAct
PDGFC PLAU 25348397 N/A physical interaction ComPPI
MYC PLAU 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SERPINE2 PLAU 25348397 26186194 27898060 9184208 N/A physical interaction ComPPI,OmniPath
ANG PLAU 24234451 24457100 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ADAM28 PLAU 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ELAVL1 PLAU 25348397 N/A physical interaction ComPPI
KAT8 PLAU 25348397 N/A physical interaction ComPPI
SCAMP5 PLAU 25348397 N/A physical interaction ComPPI
PPP4R4 PLAU 25348397 N/A physical interaction ComPPI
ALAS1 PLAU 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRP2 PLAU 14525934 25348397 8344937 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PLAU TEX101 25348397 N/A physical interaction ComPPI
PLAU SLURP1 24234451 25168896 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
PLAU SERPINB6 14525934 7548163 N/A experimental interaction detection HPRD
PLAU PLG 14525934 2829380 3920216 4226004 N/A experimental interaction detection HPRD
F2 PLAU 10996659 14525934 8428004 N/A experimental interaction detection HPRD
ST14 PLAU 10962009 14525934 N/A experimental interaction detection HPRD
CTSB PLAU 14525934 1900515 N/A experimental interaction detection HPRD
CTSL PLAU 14525934 1551416 N/A experimental interaction detection HPRD
SERPINF2 PLAU 134998 14525934 N/A experimental interaction detection HPRD
HGF PLAU 1334458 14525934 N/A experimental interaction detection HPRD
PLAU NID1 14525934 1499567 27898060 N/A experimental interaction detection HPRD,OmniPath
PLAU IGF2R 14525934 27898060 9566979 N/A experimental interaction detection HPRD,OmniPath
PRKCA PLAU 27898060 9765311 N/A N/A OmniPath
PLAU PLAUR 11501527 16456079 16879932 18376415 19017363 27898060 3023326 3031025 stimulant N/A OmniPath

Visualization










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