Gene Information gene info

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GENE：PSEN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSEN1
FullNmae presenilin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9508
EnsembleID ENSG00000080815
Uniprot P49768

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSEN1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSEN1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSEN1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSEN1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSEN1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSEN1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PSEN1 GO:0000045,GO:0000122,GO:0000139,GO:0000776,GO:0001568,GO:0001708,GO:0001756,GO:0001764,GO:0001921,GO:0001933,GO:0001934,GO:0001947,GO:0002038,GO:0002244,GO:0002265,GO:0002286,GO:0003407,GO:0004175,GO:0004175,GO:0004175,GO:0004175,GO:0004190,GO:0005262,GO:0005515,GO:0005634,GO:0005634,GO:0005640,GO:0005654,GO:0005739,GO:0005743,GO:0005765,GO:0005783,GO:0005783,GO:0005789,GO:0005790,GO:0005791,GO:0005794,GO:0005813,GO:0005886,GO:0005886,GO:0005938,GO:0006509,GO:0006509,GO:0006816,GO:0006839,GO:0006974,GO:0006979,GO:0007219,GO:0007220,GO:0007220,GO:0007220,GO:0007611,GO:0007611,GO:0007613,GO:0008013,GO:0008013,GO:0008021,GO:0009791,GO:0009986,GO:0010468,GO:0010628,GO:0010629,GO:0010975,GO:0015031,GO:0015871,GO:0016020,GO:0016020,GO:0016080,GO:0016235,GO:0016324,GO:0016485,GO:0016485,GO:0016485,GO:0021549,GO:0021795,GO:0021870,GO:0021904,GO:0030018,GO:0030054,GO:0030165,GO:0030326,GO:0030426,GO:0030426,GO:0031594,GO:0031901,GO:0031965,GO:0032092,GO:0032436,GO:0032469,GO:0032469,GO:0032469,GO:0032760,GO:0032991,GO:0034205,GO:0034205,GO:0034205,GO:0035253,GO:0035556,GO:0035577,GO:0040011,GO:0042307,GO:0042325,GO:0042383,GO:0042500,GO:0042500,GO:0042734,GO:0042982,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0043005,GO:0043011,GO:0043025,GO:0043065,GO:0043066,GO:0043066,GO:0043066,GO:0043085,GO:0043198,GO:0043524,GO:0043589,GO:0045121,GO:0045121,GO:0045296,GO:0045821,GO:0045893,GO:0048143,GO:0048167,GO:0048471,GO:0048538,GO:0048666,GO:0048705,GO:0048854,GO:0050435,GO:0050673,GO:0050771,GO:0050808,GO:0050820,GO:0050852,GO:0051117,GO:0051208,GO:0051402,GO:0051563,GO:0051966,GO:0060075,GO:0060828,GO:0060999,GO:0070050,GO:0070588,GO:0070765,GO:0070765,GO:0070851,GO:0097190,GO:0098609,GO:0098693,GO:0098712,GO:0098794,GO:0098978,GO:0099175,GO:0140249,GO:1904646,GO:1904797,GO:1905908,GO:1990535,GO:2000059,GO:2001234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSEN1 hsa:5663 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PSEN1 hsa:5663 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
PSEN1 hsa:5663 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PSEN1 hsa:5663 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSEN1 hsa:5663 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PSEN1 hsa:5663 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PSEN1 JAG1 22330899 22363130 26192618 interaction type N/A ACSN
PSEN1 NOTCH1 10077672 10206645 12374741 15246694 18988627 22330899 22363130 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
PSEN1 DLL1 22330899 22363130 26192618 interaction type N/A ACSN
CTNNB1 PSEN1 16126725 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSEN1 CDH1 16126725 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSEN1 TRAF6 18996842 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSEN1 IRAK2 18996842 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSEN1 GRB2 17314098 23180781 physical association anti tag coimmunoprecipitation InnateDB
CXCR1 PSEN1 23180781 24914212 physical association bioluminescence resonance energy transfer,experimental knowledge based InnateDB
PSEN1 PSENEN 12198112 12522139 14572442 21071413 23331499 interaction type N/A SignaLink,SignaLink
PSENEN PSEN1 12198112 12639958 14572442 15035625 18988627 21071413 23331499 inhibition N/A SignaLink,SignaLink
NCSTN PSEN1 10993067 12032140 12471034 12603837 14572442 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
APH1A PSEN1 20005715 interaction type N/A PSP
FLNB PSEN1 20005715 interaction type N/A PSP
NCSTN PSEN1 20005715 interaction type N/A PSP,SignaLink
PIK3R1 PSEN1 20005715 interaction type N/A PSP
APH1A PSEN1 12471034 14572442 20005715 21071413 N/A N/A SignaLink
PIK3R1 PSEN1 15192701 18988627 20005715 N/A N/A SignaLink
FLNB PSEN1 18988627 20005715 21071413 9437013 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PSEN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PSEN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PSEN1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PSEN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PSEN1 11116137 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 PSEN1 12750007 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PSEN1 10446206 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PSEN1 10446206 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 PSEN1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 PSEN1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 PSEN1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000345DEB PSEN1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00005E1A16 PSEN1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 PSEN1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000033EBB8 PSEN1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B PSEN1 22135298 phosphorylation N/A PhosphoSite
CDK5 PSEN1 22135298 phosphorylation N/A PhosphoSite
MAPK9 PSEN1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
VASN PSEN1 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS3 PSEN1 25348397 N/A physical interaction ComPPI
PKP4 PSEN1 10037471 10092585 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAPK9 PSEN1 25348397 N/A physical interaction ComPPI
RAB3A PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CFL1 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRAF6 PSEN1 25348397 N/A physical interaction ComPPI
CTNND1 PSEN1 11226248 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2L1 PSEN1 10446169 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
RPL10 PSEN1 10508860 25348397 27898060 N/A two hybrid,coimmunoprecipitation,physical interaction ComPPI,OmniPath
PIK3R1 PSEN1 14525934 15192701 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NOTCH4 PSEN1 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FBXW7 PSEN1 12354302 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
NOTCH1 PSEN1 10077672 10206645 12374741 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DLL1 PSEN1 12794186 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP3 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRAM1 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DHX9 PSEN1 25348397 N/A physical interaction ComPPI
FLNA PSEN1 14525934 24234451 25348397 9437013 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,genetic,in vivo,two hybrid ComPPI,HPRD,IntAct
PRKACA PSEN1 14525934 14576165 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CIB1 PSEN1 10366599 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RYR2 PSEN1 25348397 N/A physical interaction ComPPI
GSK3B PSEN1 11104755 14525934 16814287 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
JUP PSEN1 11226248 14525934 16306047 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GAPDH PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBA1B PSEN1 25348397 N/A physical interaction ComPPI
UBC PSEN1 25348397 N/A physical interaction ComPPI
ACTN1 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDH1 PSEN1 11953314 24234451 25348397 physical association coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
TCF7L2 PSEN1 11504726 16306047 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
CASP1 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP6 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AP1M2 PSEN1 25348397 N/A physical interaction ComPPI
CLSTN1 PSEN1 25348397 N/A physical interaction ComPPI
PSMA5 PSEN1 25348397 N/A physical interaction ComPPI
CASP7 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP8 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
APOE PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPT PSEN1 25348397 N/A physical interaction,in vivo ComPPI
ST13 PSEN1 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PRKCZ PSEN1 14525934 14576165 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HMGB1 PSEN1 25348397 N/A physical interaction ComPPI
GDI1 PSEN1 14525934 15480879 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
EFNB2 PSEN1 14525934 16511561 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
RAD23A PSEN1 25348397 N/A physical interaction ComPPI
PDCD4 PSEN1 25348397 N/A physical interaction ComPPI
SCAF11 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPB41L3 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSEN2 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DTNA PSEN1 25348397 N/A physical interaction ComPPI
DAG1 PSEN1 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APBA1 PSEN1 10551805 11083918 12196555 14525934 16007100 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct,OmniPath
RAB11A PSEN1 10369872 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
NCSTN PSEN1 10993067 12603837 14525934 16641999 18201567 24234451 25348397 29611543 association,physical association anti bait coimmunoprecipitation,cosedimentation,cosedimentation in solution,experimental interaction detection,physical interaction,blue native page,in vivo ComPPI,HPRD,IntAct
CTNND2 PSEN1 10037471 10208590 14525934 25348397 9223106 N/A two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
IRAK2 PSEN1 25348397 N/A physical interaction ComPPI
CTNNB1 PSEN1 10092585 10341227 11168528 11226248 12070348 14525934 16306047 25348397 9738936 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RHEB PSEN1 25348397 N/A physical interaction ComPPI
TDP2 PSEN1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTNNA1 PSEN1 10635315 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDK5 PSEN1 12056836 14525934 21163940 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo ComPPI,HPRD,IntAct
FLNB PSEN1 14525934 24234451 25348397 9437013 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
BCL2 PSEN1 10521466 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
HTRA2 PSEN1 10971580 24234451 25348397 physical association two hybrid ComPPI,IntAct
NPR1 PSEN1 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC37 PSEN1 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
ICAM5 PSEN1 11719200 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NOTCH2 PSEN1 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOTCH3 PSEN1 11518718 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ENSA PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP4 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNIP3 PSEN1 10854253 12207970 14525934 25348397 27898060 9771752 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
UBQLN1 PSEN1 11076969 14525934 24234451 25348397 colocalization,physical association two hybrid,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
APH1A PSEN1 24234451 25348397 26280335 physical association physical interaction,electron tomography,in vitro,in vivo ComPPI,IntAct
APH1B PSEN1 12471034 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PSENEN PSEN1 12198112 12639958 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
METTL2B PSEN1 11738826 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
DOCK3 PSEN1 10854253 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
KCNIP4 PSEN1 25348397 N/A physical interaction ComPPI
BACE1 PSEN1 12901838 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ECSIT PSEN1 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,two hybrid array ComPPI,IntAct
CDH2 PSEN1 25348397 N/A physical interaction ComPPI
ERN1 PSEN1 10587643 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSMB1 PSEN1 25348397 N/A physical interaction ComPPI
STAMBPL1 PSEN1 25348397 N/A physical interaction ComPPI
RMDN3 PSEN1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDH8 PSEN1 25348397 N/A physical interaction ComPPI
TMED10 PSEN1 16641999 24234451 25348397 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
GFAP PSEN1 12058025 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
DNER PSEN1 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DSG2 PSEN1 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSEN1 YME1L1 12214059 14525934 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
PSEN1 HERPUD1 11799129 14525934 14550564 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PSEN1 MTCH1 10551805 12377771 24234451 25348397 27898060 physical association coimmunoprecipitation,in vitro,in vivo ComPPI,IntAct,OmniPath
PSEN1 APP 10593990 14525934 21163940 24234451 25348397 9223340 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,protease assay,protein cleavage ComPPI,HPRD,IntAct
PSEN1 GCDH 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
PSEN1 KANK2 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSEN1 CYP2C18 25348397 N/A physical interaction ComPPI
PSEN1 CYP2C8 25348397 N/A physical interaction ComPPI
PSEN1 FBXL12 25348397 N/A physical interaction ComPPI
PSEN1 PRDX2 25348397 N/A physical interaction ComPPI
PSEN1 RNF32 25348397 N/A physical interaction ComPPI
PSEN1 EFHD1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSEN1 ST13P4 25348397 N/A physical interaction ComPPI
PSEN1 UMPS 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSEN1 OXCT1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSEN1 FGF13 25348397 N/A physical interaction ComPPI
PSEN1 ITSN2 25348397 N/A physical interaction ComPPI
PSEN1 SCN1A 25348397 N/A physical interaction ComPPI
PSEN1 DSP 25348397 N/A physical interaction ComPPI
PSEN1 NDUFS8 25348397 N/A physical interaction ComPPI
PSEN1 ETFA 25348397 N/A physical interaction ComPPI
PSEN1 ERLIN2 25348397 N/A physical interaction ComPPI
PSEN1 TGFBR1 25348397 N/A physical interaction ComPPI
PSEN1 TCF4 25348397 N/A physical interaction ComPPI
PSEN1 GSAP 25348397 N/A physical interaction ComPPI
PSEN1 UNK 25348397 N/A physical interaction ComPPI
PSEN1 PTGER4 25348397 N/A physical interaction ComPPI
PSEN1 SPPL2B 25348397 N/A physical interaction ComPPI
PSEN1 PLXDC2 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSEN1 PSEN1 12535650 14525934 N/A two hybrid HPRD
PSEN1 APBA2 24234451 29578633 N/A fluorescence polarization spectroscopy IntAct
PSEN1 TREM2 24234451 29611543 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,confocal microscopy IntAct
CDK5 PSEN1 12056836 21163940 27898060 stimulant N/A OmniPath
PRKCA PSEN1 14576165 27898060 stimulant N/A OmniPath
PSEN1 CTNNB1 10037471 10092585 10341227 11161700 11168528 11226248 12070348 16126725 16306047 17145710 17360711 2195779 27898060 9223106 9632714 9738936 9852041 inhibition,stimulant N/A OmniPath
PRKCB PSEN1 14576165 27898060 stimulant N/A OmniPath
CASP1 PSEN1 10069390 27898060 N/A N/A OmniPath
CASP7 PSEN1 10069390 27898060 N/A N/A OmniPath
MAPK9 PSEN1 18667537 27898060 stimulant N/A OmniPath
CASP3 PSEN1 10069390 27898060 N/A N/A OmniPath
PSEN1 APP 10078972 10593990 12011466 21163940 27898060 9223340 N/A N/A OmniPath
PSEN1 TRAF6 18996842 19012753 23707529 24399296 27898060 inhibition N/A OmniPath
TRAF6 PSEN1 18996842 19012753 23707529 24399296 27898060 N/A N/A OmniPath
GSK3A PSEN1 11104755 27898060 9689133 inhibition N/A OmniPath
PRKCG PSEN1 14576165 27898060 stimulant N/A OmniPath
PSEN1 GRB2 17314098 27898060 N/A N/A OmniPath
PSEN1 JAG2 12551931 27898060 N/A N/A OmniPath
PRKCZ PSEN1 14576165 27898060 stimulant N/A OmniPath
CASP8 PSEN1 10069390 27898060 N/A N/A OmniPath
CASP6 PSEN1 10069390 27898060 N/A N/A OmniPath
PSEN1 NOTCH1 10077672 10206645 10593990 12374741 15246694 27898060 stimulant N/A OmniPath
GSK3B PSEN1 11104755 12056836 12805290 14576165 16814287 17360711 17389597 27898060 inhibition N/A OmniPath
PSEN1 NCSTN 10993067 11943765 12297508 12471034 12603837 14572442 15257293 15474363 17911105 18201567 27898060 stimulant N/A OmniPath
NCSTN PSEN1 10993067 11943765 12032140 12297508 12471034 12603837 14572442 15257293 15474363 17911105 18201567 27898060 stimulant N/A OmniPath
PSEN1 PSENEN 12198112 12522139 12639958 14572442 15035625 15474363 22074918 27898060 N/A N/A OmniPath
PSENEN PSEN1 12198112 12522139 12639958 14572442 15035625 15474363 22074918 27898060 inhibition,stimulant N/A OmniPath
CXCR1 PSEN1 24914212 27898060 N/A N/A OmniPath
APH1A PSEN1 12297508 12471034 12522139 14572442 15146195 15474363 17911105 27898060 stimulant N/A OmniPath
APH1B PSEN1 12471034 12522139 27898060 stimulant N/A OmniPath
TMED10 PSEN1 16641999 27898060 stimulant N/A OmniPath
SCAF11 PSEN1 10069390 27898060 N/A N/A OmniPath

Visualization










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