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GENE：PTGS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTGS1
FullNmae prostaglandin-endoperoxide synthase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9604
EnsembleID ENSG00000095303
Uniprot P23219

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTGS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTGS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PTGS1 GO:0001516,GO:0001750,GO:0004601,GO:0004666,GO:0004666,GO:0005515,GO:0005737,GO:0005737,GO:0005737,GO:0005789,GO:0005794,GO:0006979,GO:0008217,GO:0016702,GO:0019371,GO:0019371,GO:0020037,GO:0042127,GO:0043005,GO:0043231,GO:0046872,GO:0070062,GO:0098869

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTGS1 hsa:5742 path:hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
PTGS1 hsa:5742 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PTGS1 hsa:5742 path:hsa04611 Platelet activation - Homo sapiens (human)
PTGS1 hsa:5742 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PTGS1 hsa:5742 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PTGS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA1 PTGS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PTGS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PTGS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF10 PTGS1 23178857 trascriptional regulation,stimulation inferred by curator TFlink
KMT2B PTGS1 19570036 trascriptional regulation,stimulation inferred by curator TFlink
KMT2D PTGS1 19570036 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PTGS1 19570036 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 PTGS1 19570036 trascriptional regulation,stimulation inferred by curator TFlink
RELA PTGS1 19570036 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB PTGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PTGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN PTGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB PTGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA PTGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTGS1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000035CC3E PTGS1 19536157 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000075AAA0 PTGS1 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000299AD8 PTGS1 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000134ADC PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000547F6A PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B PTGS1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TP53BP1 PTGS1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
CAV1 PTGS1 25348397 N/A physical interaction ComPPI
CAV2 PTGS1 25348397 N/A physical interaction ComPPI
PTGS2 PTGS1 25348397 N/A physical interaction ComPPI
PTGS1 NCL 17320986 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PTGS1 FBXO6 25348397 N/A physical interaction ComPPI

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