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GENE：PTGS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTGS2
FullNmae prostaglandin-endoperoxide synthase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9605
EnsembleID ENSG00000073756
Uniprot P35354

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTGS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTGS2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTGS2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PTGS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PTGS2 apoptosis 38643900 CRISPR/Cas9 knockout of Ptgs2 promotes apoptosis of hepatic stellate cells. retulator signature

Go Annotation:

GeneSymbol Go id
PTGS2 GO:0001516,GO:0001516,GO:0001516,GO:0001525,GO:0004601,GO:0004666,GO:0004666,GO:0005515,GO:0005637,GO:0005640,GO:0005737,GO:0005737,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005901,GO:0006979,GO:0007566,GO:0007612,GO:0007613,GO:0008217,GO:0008285,GO:0009410,GO:0009624,GO:0009750,GO:0010042,GO:0010575,GO:0016702,GO:0019371,GO:0019371,GO:0019899,GO:0020037,GO:0030282,GO:0031394,GO:0031622,GO:0031915,GO:0032227,GO:0032310,GO:0032355,GO:0032496,GO:0032991,GO:0033138,GO:0033280,GO:0034605,GO:0034612,GO:0035633,GO:0042307,GO:0042633,GO:0042803,GO:0043005,GO:0043005,GO:0043065,GO:0045429,GO:0045786,GO:0045907,GO:0045986,GO:0045987,GO:0046697,GO:0046872,GO:0048661,GO:0050727,GO:0050873,GO:0051384,GO:0051926,GO:0051968,GO:0070542,GO:0071260,GO:0071284,GO:0071318,GO:0071456,GO:0071471,GO:0071498,GO:0071636,GO:0090050,GO:0090271,GO:0090336,GO:0090362,GO:0098869,GO:0150077,GO:1902219,GO:1990776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTGS2 hsa:5743 path:hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04148 Efferocytosis - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05140 Leishmaniasis - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05204 Chemical carcinogenesis - DNA adducts - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PTGS2 hsa:5743 path:hsa05222 Small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTGS2 EGFR 18633355 20138012 21847358 23010081 23390297 25987127 26192618 interaction type N/A ACSN
PTGS2 AREG 18633355 20138012 21847358 23010081 23390297 25987127 26192618 interaction type N/A ACSN
MIF PTGS2 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
CEBPD PTGS2 11668179 26192618 interaction type N/A ACSN
CEBPB PTGS2 18820298 20581311 23180781 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
CREB1 PTGS2 11579131 15187187 15749884 16007092 16319525 16713974 17404308 20547845 23180781 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
KLF4 PTGS2 10432118 10925299 12193690 21093321 21670502 23390297 26192618 6357187 interaction type N/A ACSN
COPS3 PTGS2 17429597 23180781 physical association anti tag coimmunoprecipitation InnateDB
COPS5 PTGS2 17429597 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL1 PTGS2 17429597 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSMD1 PTGS2 17429597 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELAVL1 PTGS2 11733561 18362203 19289500 23180781 physical association anti tag coimmunoprecipitation,nucleic acid uv cross-linking assay InnateDB
JUN PTGS2 20042607 21790943 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
FOS PTGS2 20042607 23180781 physical association affinity chromatography technology InnateDB
RELA PTGS2 11971025 21790943 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NFKB1 PTGS2 11971025 21963853 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
PTGS2 PLA2G4A 18029351 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTGS2 CEBPD 16397300 18820298 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUMO1 PTGS2 16397300 18820298 21187340 23180781 physical association anti tag coimmunoprecipitation InnateDB
HDAC4 PTGS2 18820298 23180781 physical association anti tag coimmunoprecipitation InnateDB
HDAC1 PTGS2 18820298 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 PTGS2 16397300 21187340 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAD21 PTGS2 22145905 23180781 physical association two hybrid InnateDB
TP53I3 PTGS2 21187340 23180781 physical association anti tag coimmunoprecipitation InnateDB
BAX PTGS2 21187340 23180781 physical association anti tag coimmunoprecipitation InnateDB
TP53 PTGS2 21187340 23180781 physical association anti tag coimmunoprecipitation InnateDB
BAG1 PTGS2 21963853 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ATF4 PTGS2 12057991 21244365 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PTGS2 10956548 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
CEBPB PTGS2 10956548 16699180 16820889 17556653 18294142 18820298 7559624 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
CEBPD PTGS2 10956548 7559624 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ATF2 PTGS2 11278336 12057991 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PTGS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
JUN PTGS2 11278336 12057991 15772294 16339564 17556653 18294142 20237399 9620167 trascriptional regulation,stimulation inferred by curator TFlink
USF2 PTGS2 12057991 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 PTGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PTGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PTGS2 15517885 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PTGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PTGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
APC PTGS2 10772828 11396184 12566320 trascriptional regulation,stimulation inferred by curator TFlink
AR PTGS2 18386814 trascriptional regulation,stimulation inferred by curator TFlink
CDX1 PTGS2 21613300 trascriptional regulation,stimulation inferred by curator TFlink
CDX2 PTGS2 15013430 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 PTGS2 22919060 trascriptional regulation,stimulation inferred by curator TFlink
CREBBP PTGS2 11278336 trascriptional regulation,stimulation inferred by curator TFlink
CTNNB1 PTGS2 11396184 trascriptional regulation,stimulation inferred by curator TFlink
DR1 PTGS2 11840453 trascriptional regulation,stimulation inferred by curator TFlink
EGR2 PTGS2 24007274 trascriptional regulation,stimulation inferred by curator TFlink
ELF3 PTGS2 15794755 trascriptional regulation,stimulation inferred by curator TFlink
ENO1 PTGS2 19846662 trascriptional regulation,stimulation inferred by curator TFlink
EP300 PTGS2 12057991 12471036 17237818 17395887 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 PTGS2 11274170 trascriptional regulation,stimulation inferred by curator TFlink
FOS PTGS2 11278336 12057991 17556653 9620167 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 PTGS2 17395887 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 PTGS2 18820298 trascriptional regulation,stimulation inferred by curator TFlink
HMGA1 PTGS2 22898640 trascriptional regulation,stimulation inferred by curator TFlink
ING4 PTGS2 18399550 trascriptional regulation,stimulation inferred by curator TFlink
JUNB PTGS2 9620167 trascriptional regulation,stimulation inferred by curator TFlink
JUND PTGS2 9620167 trascriptional regulation,stimulation inferred by curator TFlink
NFIL3 PTGS2 1620116 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PTGS2 10827178 12067569 12349897 12471036 12622742 12871860 14988266 15368354 15387324 15517885 15547942 15555528 15655349 15997464 16210649 16624933 16820889 17556653 17673602 17767925 18057724 18294142 18973191 19618291 19766095 20103608 20669087 22001128 trascriptional regulation,stimulation inferred by curator TFlink
NR0B2 PTGS2 21613300 trascriptional regulation,stimulation inferred by curator TFlink
PGR PTGS2 18483177 trascriptional regulation,stimulation inferred by curator TFlink
PPARA PTGS2 11412039 trascriptional regulation,stimulation inferred by curator TFlink
PPARG PTGS2 10827178 11278336 11412039 14555539 16506021 trascriptional regulation,stimulation inferred by curator TFlink
RELA PTGS2 10827178 12067569 12349897 12471036 12622742 12871860 14645117 14988266 15368354 15387324 15517885 15547942 15555528 15655349 15997464 16210649 16624933 16820889 17556653 17673602 17767925 18057724 18294142 18973191 19618291 19766095 20103608 20669087 22001128 trascriptional regulation,stimulation inferred by curator TFlink
SETBP1 PTGS2 18419541 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PTGS2 15767339 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PTGS2 15767339 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 PTGS2 10433370 12586443 16685393 trascriptional regulation,stimulation inferred by curator TFlink
STAT2 PTGS2 12586443 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 PTGS2 20145033 21172343 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 PTGS2 17237818 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 PTGS2 11396184 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PTGS2 16423197 trascriptional regulation,stimulation inferred by curator TFlink
USF1 PTGS2 18817855 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
REL PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTGS2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 PTGS2 N/A rna interference,inhibition experimental interaction detection miRSponge
URS00001E3523 PTGS2 22406049 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000003ABC4 PTGS2 20100477 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS0000324096 PTGS2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS000003ABC4 PTGS2 20100477 23374284 25416803 27769043 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E3523 PTGS2 22406049 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000008A99 PTGS2 21790228 24105952 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 PTGS2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000028BB8 PTGS2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00001EFBE3 PTGS2 22699322 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004214BB PTGS2 23999091 25416803 mrna cleavage,inhibition experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr TarBase
URS00001EE123 PTGS2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 PTGS2 25416803 26959737 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 PTGS2 25347932 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
FYN PTGS2 22135298 phosphorylation N/A PhosphoSite
LYN PTGS2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
AGTR1 PTGS2 25348397 N/A physical interaction ComPPI
VCP PTGS2 25348397 N/A physical interaction ComPPI
MAPK3 PTGS2 25348397 N/A physical interaction ComPPI
SUMO1 PTGS2 25348397 N/A physical interaction ComPPI
EP300 PTGS2 25348397 N/A physical interaction ComPPI
COPS5 PTGS2 25348397 N/A physical interaction ComPPI
RBX1 PTGS2 25348397 N/A physical interaction ComPPI
CAV1 PTGS2 11432874 14525934 19960513 24089527 25348397 27898060 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PSMD1 PTGS2 25348397 N/A physical interaction ComPPI
CASK PTGS2 25348397 N/A physical interaction ComPPI
ELMO1 PTGS2 25348397 N/A physical interaction ComPPI
PSMC5 PTGS2 25348397 N/A physical interaction ComPPI
CUL1 PTGS2 25348397 N/A physical interaction ComPPI
CUL4A PTGS2 25348397 N/A physical interaction ComPPI
HSPA4 PTGS2 25348397 N/A physical interaction ComPPI
CTNNB1 PTGS2 25348397 N/A physical interaction ComPPI
PTGS2 ABHD16A 14525934 14667819 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PTGS2 TP53 11687965 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PTGS2 COPS7A 25348397 N/A physical interaction ComPPI
PTGS2 COPS3 25348397 N/A physical interaction ComPPI
PTGS2 PTGIS 25348397 N/A physical interaction ComPPI
PTGS2 DERL1 25348397 N/A physical interaction ComPPI
PTGS2 SELENOS 25348397 N/A physical interaction ComPPI
PTGS2 ELAVL1 25348397 N/A physical interaction ComPPI
PTGS2 CELF2 25348397 N/A physical interaction ComPPI
PTGS2 PTGS1 25348397 N/A physical interaction ComPPI
PTGS2 HNRNPD 25348397 N/A physical interaction ComPPI
PTGS2 USP22 25348397 25817787 27898060 N/A physical interaction ComPPI,OmniPath
PTGS2 FAF2 25348397 N/A physical interaction ComPPI
PTGS2 APP 25348397 N/A physical interaction ComPPI
PTGS2 PTGER1 25348397 N/A physical interaction ComPPI
PTGS2 LMAN2L 25348397 N/A physical interaction ComPPI
PTGS2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NUCB1 PTGS2 14525934 18493301 25348397 27898060 8643612 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
PTGS2 PTGS2 14525934 14667819 16606823 24234451 physical association anti tag coimmunoprecipitation,two hybrid HPRD,IntAct
HLA-A PTGS2 24234451 30021884 physical association cross-linking study IntAct
MT-CYB PTGS2 22904327 23007649 27898060 N/A N/A OmniPath
SCO1 PTGS2 11086158 11546815 27898060 N/A N/A OmniPath
PTGS2 COX20 10671482 22904327 27898060 N/A N/A OmniPath
FYN PTGS2 24970799 27898060 N/A N/A OmniPath
ELAVL1 PTGS2 17383427 18285462 18449856 19246637 22544606 27898060 stimulant N/A OmniPath
PTGS2 TP53 11687965 16928824 19465063 21187340 27898060 N/A N/A OmniPath
ERBB2 PTGS2 19861462 27898060 stimulant N/A OmniPath
PTGS2 NFE2L2 15917255 27898060 N/A N/A OmniPath
PTGS2 EP300 16928824 21187340 27898060 N/A N/A OmniPath
PTGS2 KEAP1 15917255 27898060 inhibition N/A OmniPath
JUN PTGS2 17138645 27898060 inhibition,stimulant N/A OmniPath

Visualization










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