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GENE：XPA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol XPA
FullNmae XPA, DNA damage recognition and repair factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12814
EnsembleID ENSG00000136936
Uniprot P23025

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
XPA parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
XPA autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
XPA GO:0000110,GO:0000715,GO:0003684,GO:0003684,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006281,GO:0006281,GO:0006284,GO:0006289,GO:0009650,GO:0009650,GO:0010996,GO:0019904,GO:0034504,GO:0042803,GO:0045171,GO:0046872,GO:0070914,GO:1901255,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
XPA hsa:7507 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
XPA hsa:7507 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK7 XPA 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
ERCC1 XPA 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
MNAT1 XPA 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
RPA2 XPA 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 interaction type N/A ACSN
XPA XAB2 11900249 12648680 12947387 15459660 15703371 16697054 17116885 17296725 17386261 17582221 17884153 18677104 19473888 19595721 19596235 19596236 19667075 19686080 19793801 19809470 19847258 20211143 21376743 22101340 22257761 22373527 22615860 22743550 22824526 23085398 24050180 26192618 7533895 association N/A ACSN
ATR XPA 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 26192618 9488723 9858600 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR XPA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 XPA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 XPA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 XPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DDB2 XPA 24953096 trascriptional regulation,stimulation inferred by curator TFlink
ERCC2 XPA 24953096 trascriptional regulation,stimulation inferred by curator TFlink
HMGA1 XPA 17616660 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000055128B XPA 19141645 rna interference,inhibition western blot miRSponge
URS0000508C13 XPA 19141645 rna interference,inhibition western blot miRSponge
URS000055128B XPA 19141645 25416803 mrna cleavage,inhibition western blot TarBase
URS0000508C13 XPA 19141645 25416803 mrna cleavage,inhibition western blot TarBase
URS00000B59A2 XPA 16822819 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKDC XPA 22135298 phosphorylation N/A PhosphoSite
ATR XPA 22135298 phosphorylation N/A PhosphoSite
ATM XPA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RPA1 XPA 25361965 interaction type N/A PTMCode2
XPA RPA1 25361965 interaction type N/A PTMCode2
XPA ATM 25361965 interaction type N/A PTMCode2
RASSF1 XPA 25361965 interaction type N/A PTMCode2
XPA RASSF1 25361965 interaction type N/A PTMCode2
ERCC1 XPA 25361965 interaction type N/A PTMCode2
XPA ERCC1 25361965 interaction type N/A PTMCode2
MSH2 XPA 25361965 interaction type N/A PTMCode2
XPA MSH2 25361965 interaction type N/A PTMCode2
ERCC6 XPA 25361965 interaction type N/A PTMCode2
XPA ERCC6 25361965 interaction type N/A PTMCode2
ERCC4 XPA 25361965 interaction type N/A PTMCode2
XPA ERCC4 25361965 interaction type N/A PTMCode2
RAD23B XPA 25361965 interaction type N/A PTMCode2
XPA RAD23B 25361965 interaction type N/A PTMCode2
GPN1 XPA 25361965 interaction type N/A PTMCode2
XPA GPN1 25361965 interaction type N/A PTMCode2
MSH3 XPA 25361965 interaction type N/A PTMCode2
XPA MSH3 25361965 interaction type N/A PTMCode2
XPA ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 XPA 25361965 interaction type N/A PTMCode2
DDB2 XPA 25361965 interaction type N/A PTMCode2
XPA DDB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TBC1D7 XPA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MSH3 XPA 25348397 N/A physical interaction ComPPI
SKIL XPA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA RPA1 12527904 14525934 20304803 24234451 25348397 7565690 association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
XPA RPA2 10982866 11081631 12527904 14525934 20304803 20670893 24234451 25348397 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,nuclear magnetic resonance,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
XPA GTF2E2 14525934 25348397 27898060 7876263 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
XPA GTF2H1 14525934 25348397 9698541 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XPA RASSF1 10888881 14525934 24234451 25348397 27898060 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct,OmniPath
XPA RPA4 14525934 25348397 7565690 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
XPA GPN1 11058119 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
XPA XAB2 10944529 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
XPA ATR 14525934 16540648 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
XPA PRKDC 14525934 16540648 20304803 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
XPA ATM 14525934 16540648 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XPA ERCC1 11058119 14525934 16491090 24234451 25348397 25416956 7598728 8197174 9653453 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
XPA DDB2 14525934 19056823 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XPA ERCC6 14525934 25348397 8999876 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XPA EP300 25348397 N/A physical interaction ComPPI
XPA ERCC6 25348397 N/A physical interaction ComPPI
XPA MSH2 25348397 N/A physical interaction ComPPI
XPA XPC 25348397 N/A physical interaction ComPPI
XPA POLR2A 25348397 N/A physical interaction ComPPI
XPA DDB1 25348397 N/A physical interaction ComPPI
XPA HMGB1 25348397 N/A physical interaction ComPPI
XPA HERC2 20304803 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPA HERC2P3 25348397 N/A physical interaction ComPPI
XPA TRIM27 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XPA NDEL1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
XPA ERCC4 25348397 N/A physical interaction ComPPI
XPA NUP43 25348397 N/A physical interaction ComPPI
XPA ZNF518A 25348397 N/A physical interaction ComPPI
XPA XPO1 25348397 N/A physical interaction ComPPI
XPA RHOU 25348397 N/A physical interaction ComPPI
XPA SPTA1 25348397 N/A physical interaction ComPPI
XPA FOSL1 25348397 N/A affinity chromatography technology,physical interaction ComPPI
XPA UBB 25348397 N/A physical interaction,comigration in sds page ComPPI
XPA UBC 25348397 N/A physical interaction,comigration in sds page ComPPI
XPA RPS27A 25348397 N/A physical interaction,comigration in sds page ComPPI
XPA UBA52 25348397 N/A physical interaction,comigration in sds page ComPPI
XPA POLR1G 11058119 24234451 25348397 physical association two hybrid ComPPI,IntAct
XPA SIRT1 20670893 24234451 25348397 deacetylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,deacetylase assay ComPPI,IntAct
XPA AURKA 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA BMPR1A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA DLC1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA FBXW7 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA MLH1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA MUTYH 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA NRAS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA PDGFRL 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA PMS2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA RB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA SMAD2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA SRC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA STK11 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA VPS26C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA DVL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA ARID3A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA PICK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA ZNF655 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPA SNPH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB1 XPA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
H1-2 XPA 24234451 30021884 physical association cross-linking study IntAct
ATR XPA 16540648 18594563 19586908 23178497 27898060 stimulant N/A OmniPath
ATM XPA 16540648 19586908 23178497 27898060 N/A N/A OmniPath
XPA ERCC4 17948053 27898060 stimulant N/A OmniPath
ERCC8 XPA 27898060 8999876 stimulant N/A OmniPath
XPA CEP164 19197159 27898060 stimulant N/A OmniPath
XPA ERCC1 11058119 16491090 17948053 19056823 25416956 26186194 27898060 7598728 7876167 8197174 8972858 9653453 stimulant N/A OmniPath
HERC2 XPA 20304803 23178497 27898060 inhibition N/A OmniPath

Visualization










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