Gene Information gene info

  1. Home

GENE：RELB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RELB
FullNmae RELB proto-oncogene, NF-kB subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9956
EnsembleID ENSG00000104856
Uniprot Q01201

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RELB pyroptosis 29844574 SIRT1-knocked-down cells showed representative features of pyroptosis, as well as highly expressed absent in melanoma 2 (AIM2) and its downstream genes related to the inflammasome response. Mechanistically, SIRT1 repressed the NF-κB-driven transcription of the AIM2 gene by destabilizing the RELB mRNA. retulator signature
RELB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RELB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RELB GO:0000785,GO:0000785,GO:0000978,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005813,GO:0005829,GO:0005829,GO:0006954,GO:0007249,GO:0017053,GO:0019882,GO:0019901,GO:0030098,GO:0032688,GO:0032922,GO:0032991,GO:0033554,GO:0034097,GO:0038061,GO:0042802,GO:0043011,GO:0045063,GO:0045087,GO:0045202,GO:0045892,GO:0045944,GO:0045944,GO:0071159,GO:0071470

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RELB hsa:5971 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RELB hsa:5971 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
RELB hsa:5971 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
RELB hsa:5971 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
RELB hsa:5971 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
RELB hsa:5971 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKG RELB 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 26192618 2649237 28462531 interaction type N/A ACSN
MALT1 RELB 17948050 18264101 21873235 26192618 interaction type N/A ACSN
VEGFA RELB 10022831 11166270 11960372 12629515 13678960 15099563 15111329 15501236 15520864 15573129 16002046 16572188 17086423 19414323 21372296 22064427 22461508 23390297 24346288 26192618 26201938 8837607 9157999 9570538 9753319 interaction type N/A ACSN
PDE8A RELB 15596729 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB RELA 12657634 15722553 16951372 19122653 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
RELB BIRC3 16982744 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
RELB DAXX 16982744 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAC1 RELB 16551621 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB NFKB2 12820969 12927781 16108830 16551621 17548614 23180781 7925301 physical association anti tag coimmunoprecipitation InnateDB
CXCL8 RELB 17823304 23180781 physical association electrophoretic mobility supershift assay InnateDB
AHR RELB 17823304 17900530 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CYP1A1 RELB 17823304 23180781 physical association electrophoretic mobility supershift assay InnateDB
VDR RELB 14507914 23180781 physical association electrophoretic mobility supershift assay InnateDB
NFKB1 RELB 12820969 15722553 18321863 23180781 7925301 9315679 physical association anti tag coimmunoprecipitation,two hybrid,electrophoretic mobility shift assay InnateDB
REL RELB 12657634 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKB2 RELB 12709443 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKBIA RELB 12820969 19020113 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB CCL19 12820969 17182562 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
CCL22 RELB 12820969 19122653 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL12B RELB 12820969 19122653 23180781 physical association anti tag coimmunoprecipitation InnateDB
SKP2 RELB 15596805 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 RELB 16272311 23180781 physical association affinity chromatography technology InnateDB
IFNB1 RELB 15699120 23180781 physical association affinity chromatography technology InnateDB
IFNL1 RELB 17785777 23180781 physical association affinity chromatography technology InnateDB
IFNL3 RELB 17785777 23180781 physical association affinity chromatography technology InnateDB
RELB IL1B 19122653 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL17 RELB 19122653 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB SIRT1 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB TNF 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB CCL5 12820969 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB BCL10 22579587 23180781 physical association anti tag coimmunoprecipitation,antisense oligonucleotides InnateDB
RELB EZH2 23180781 25255445 physical association anti tag coimmunoprecipitation InnateDB
RELB CDK6 23180781 25255445 physical association anti tag coimmunoprecipitation InnateDB
RELB PSMA5 23180781 25255445 physical association anti tag coimmunoprecipitation InnateDB
RELB ANAPC1 23180781 25255445 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 RELB 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RELB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RELB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ARNT RELB 17900530 trascriptional regulation,stimulation inferred by curator TFlink
JUN RELB 15596805 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 RELB N/A trascriptional regulation,stimulation inferred by curator TFlink
RELA RELB N/A trascriptional regulation,stimulation inferred by curator TFlink
RELB RELB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 RELB 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B RELB 22135298 phosphorylation N/A PhosphoSite
CHUK RELB 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IKBKB RELB 22135298 phosphorylation N/A PhosphoSite
BCL3 RELB 25361965 interaction type N/A PTMCode2
RELB BCL3 25361965 interaction type N/A PTMCode2
NFKB2 RELB 25361965 interaction type N/A PTMCode2
RELB NFKB2 25361965 interaction type N/A PTMCode2
RELB NFKB1 25361965 interaction type N/A PTMCode2
NFKB1 RELB 25361965 interaction type N/A PTMCode2
RELB NFKBIE 25361965 interaction type N/A PTMCode2
NFKBIE RELB 25361965 interaction type N/A PTMCode2
RELB NFKBIB 25361965 interaction type N/A PTMCode2
NFKBIB RELB 25361965 interaction type N/A PTMCode2
RELB CHUK 25361965 interaction type N/A PTMCode2
RELB EHMT2 25361965 interaction type N/A PTMCode2
EHMT2 RELB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NUDT21 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMARCE1 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
DAXX RELB 25348397 N/A physical interaction ComPPI
HSPA8 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CTSL RELB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NQO2 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACTG1 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMARCC1 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
TUBB RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
KPNA1 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CALM1 RELB 25348397 N/A tandem affinity purification ComPPI
RAC1 RELB 25348397 N/A physical interaction ComPPI
EHMT2 RELB 25348397 N/A physical interaction ComPPI
EZH2 RELB 25348397 N/A physical interaction ComPPI
REL RELB 25348397 N/A physical interaction ComPPI
PRKDC RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMARCD1 RELB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
USP7 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NONO RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SFPQ RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GSK3B RELB 21217772 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,physical interaction,protein kinase assay ComPPI,IntAct
KPNB1 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PFKL RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBB RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RUVBL1 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPA5 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SMARCA4 RELB 14743216 24234451 25348397 physical association physical interaction,in vitro,tandem affinity purification ComPPI,IntAct
SIN3A RELB 14525934 17962807 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HNRNPU RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIA RELB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
C1QBP RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAD RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ARID1B RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELA RELB 14525934 14743216 22808155 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
EPRS1 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
XPO1 RELB 25348397 N/A physical interaction ComPPI
SMARCB1 RELB 14525934 14743216 25348397 N/A experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD
CLTC RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPLP2 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
YY1 RELB 25348397 N/A physical interaction ComPPI
HDAC6 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
ACTL6A RELB 25348397 N/A physical interaction,physical interaction,tandem affinity purification,tandem affinity purification ComPPI
CHUK RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TNIP2 RELB 25348397 N/A physical interaction ComPPI
HSPA9 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
USP11 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
COMMD1 RELB 15799966 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
BCL3 RELB 25348397 N/A physical interaction ComPPI
NFKB1 RELB 14525934 14743216 17962807 21988832 24234451 25348397 25609649 association,physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
NFKB2 RELB 12505990 14525934 14743216 17962807 24234451 25348397 physical association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
DDX1 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUBB4A RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
KPNA6 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
STAT3 RELB 25348397 N/A physical interaction ComPPI
SMARCD3 RELB 25348397 N/A physical interaction ComPPI
SMARCC2 RELB 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
SMARCD2 RELB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
NEK6 RELB 25348397 N/A physical interaction ComPPI
MALT1 RELB 25348397 N/A physical interaction ComPPI
RPS10 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SUZ12 RELB 25348397 N/A physical interaction ComPPI
KLHL20 RELB 25348397 N/A physical interaction ComPPI
TIMM50 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DSP RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NFKBIE RELB 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
RELB BCL7A 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
RELB DPF2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
RELB CBX3 25348397 N/A physical interaction ComPPI
RELB COMMD2 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RELB COMMD4 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RELB COMMD5 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RELB COMMD8 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RELB COMMD9 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RELB COMMD10 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RELB DNMT1 25348397 N/A physical interaction ComPPI
RELB CDK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RELB MT1M 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RELB MTAP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RELB UQCRFS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RELB BUD31 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RELB CTBS 25348397 N/A physical interaction ComPPI
RELB SMARCA2 25348397 N/A physical interaction ComPPI
RELB HSPA1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB RPS5 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB HSD17B4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB RPS11 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB CPSF6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB RPLP0P6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB RPL30 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB USP9X 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB COMMD3 15799966 24234451 25348397 association pull down ComPPI,IntAct
RPS14 RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RELB RELB 14525934 14743216 17962807 24234451 physical association experimental interaction detection,tandem affinity purification HPRD,IntAct
CALM2 RELB 14743216 24234451 physical association tandem affinity purification IntAct
RELB BCL10 22579587 27898060 N/A N/A OmniPath
NFKB1 RELB 12505990 14743216 15145317 15214841 15371334 17072323 17561400 17962807 18321863 21988832 27898060 7410453354 7925301 9135156 9315679 N/A N/A OmniPath
RELB NFKB1 12505990 14743216 15145317 15214841 15371334 17072323 17561400 17962807 18321863 21988832 27898060 7410453354 7925301 9135156 9315679 N/A N/A OmniPath
SIRT1 RELB 15152190 18193389 19408108 21245135 27898060 inhibition N/A OmniPath
RELB REL 12657634 27898060 N/A N/A OmniPath
RAC1 RELB 16551621 27898060 N/A N/A OmniPath
RELB RAC1 16551621 27898060 N/A N/A OmniPath
CARM1 RELB 15616592 27898060 stimulant N/A OmniPath
RELB EZH2 21884980 25255445 27898060 N/A N/A OmniPath
CREBBP RELB 12789342 27898060 stimulant N/A OmniPath
NFKBIA RELB 14743216 19020113 19219072 26186194 27898060 N/A N/A OmniPath
DAXX RELB 16982744 23548901 27898060 N/A N/A OmniPath
APEX1 RELB 19180539 19737086 27898060 stimulant N/A OmniPath
KMT2A RELB 19219072 27898060 stimulant N/A OmniPath
RELB RELA 10754326 12657634 14743216 16951372 17561400 19122653 21884980 25241761 27898060 N/A N/A OmniPath
RELA RELB 10754326 12657634 14743216 16951372 17561400 19122653 21884980 25241761 27898060 N/A N/A OmniPath
KMT2B RELB 19219072 27898060 stimulant N/A OmniPath
NFKB2 RELB 11687592 12505990 12709443 12927781 14678988 14743216 15145317 15218526 15371334 16108830 16285893 16551621 16793322 16970925 17072322 17072323 17254973 17548614 17561400 17962807 19098713 22388891 22864569 27898060 7925301 9681829 stimulant N/A OmniPath
RELB NFKB2 11687592 12505990 12709443 12927781 14678988 14743216 15145317 15218526 15371334 16108830 16285893 16551621 16793322 16970925 17072322 17072323 17254973 17548614 17561400 17962807 19098713 22388891 22864569 27898060 7925301 9681829 N/A N/A OmniPath
IKBKB RELB 25267645 27898060 N/A N/A OmniPath
PDE8A RELB 15596729 27898060 N/A N/A OmniPath
RELB AHR 17823304 17900530 27898060 N/A N/A OmniPath

Visualization










  Return