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GENE：RRM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RRM2
FullNmae ribonucleotide reductase regulatory subunit M2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10452
EnsembleID ENSG00000171848
Uniprot P31350

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RRM2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RRM2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RRM2 GO:0001824,GO:0004748,GO:0004748,GO:0004748,GO:0005515,GO:0005634,GO:0005829,GO:0005829,GO:0005829,GO:0005971,GO:0006260,GO:0008199,GO:0009185,GO:0009263,GO:0009263,GO:0009265,GO:0042803,GO:0051290,GO:1900087

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RRM2 hsa:6241 path:hsa00230 Purine metabolism - Homo sapiens (human)
RRM2 hsa:6241 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
RRM2 hsa:6241 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
RRM2 hsa:6241 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
RRM2 hsa:6241 path:hsa01100 Metabolic pathways - Homo sapiens (human)
RRM2 hsa:6241 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
RRM2 hsa:6241 path:hsa04115 p53 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RRM2 RRM1 26192618 interaction type N/A ACSN
RRM2B RRM2 26192618 interaction type N/A ACSN
RRM2 RRM2 26192618 interaction type N/A ACSN
RRM2 TXN 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR RRM2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 RRM2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 RRM2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A RRM2 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
YBX1 RRM2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RRM2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RRM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RRM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RRM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RRM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RRM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RRM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RRM2 19416980 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 RRM2 17699775 18668040 21572407 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,clip TarBase
URS00000AA464 RRM2 20304954 23622248 25416803 mrna cleavage,inhibition array technology,clash TarBase
URS0000338542 RRM2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000EED18 RRM2 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 RRM2 18668040 22473208 23592263 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000048BA36 RRM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE RRM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 RRM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 RRM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000029979D RRM2 21572407 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00001A405B RRM2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000044FD7 RRM2 24940696 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00002075FA RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 RRM2 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005D35D9 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C85C7 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 RRM2 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 RRM2 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000007340 RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B RRM2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003538C1 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 RRM2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D RRM2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 RRM2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C RRM2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 RRM2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA RRM2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 RRM2 22135298 phosphorylation N/A PhosphoSite
CDK2 RRM2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSPA8 RRM2 24234451 25348397 29568061 association pull down ComPPI,IntAct
MAPK1 RRM2 25348397 N/A physical interaction ComPPI
NONO RRM2 25348397 N/A physical interaction ComPPI
FZR1 RRM2 22632967 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
INPPL1 RRM2 25348397 N/A physical interaction ComPPI
HSP90AA1 RRM2 25348397 N/A physical interaction ComPPI
NTRK1 RRM2 25348397 N/A physical interaction ComPPI
CDH1 RRM2 12655059 25348397 27898060 N/A in vitro ComPPI,OmniPath
PLK1 RRM2 25348397 N/A physical interaction ComPPI
CFTR RRM2 25348397 N/A physical interaction ComPPI
SDCBP RRM2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RRM1 RRM2 11781084 14525934 17726094 21336276 22632967 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vitro ComPPI,HPRD,IntAct
RRM2 RRM2B 14525934 14729598 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RRM2 TP53 12615712 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy ComPPI,HPRD
RRM2 KAT5 25348397 N/A physical interaction ComPPI
RRM2 ELAVL1 25348397 N/A physical interaction ComPPI
RRM2 CCNF 22632967 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,confocal microscopy ComPPI,IntAct
RRM2 NR1H4 25348397 N/A physical interaction ComPPI
RRM2 SKP2 18820369 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RRM2 PCMT1 25348397 N/A physical interaction ComPPI
RRM2 RBMX 25348397 N/A physical interaction ComPPI
RRM2 DNM1L 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RRM2 CDC27 25348397 N/A physical interaction ComPPI
RRM2 ANAPC4 25348397 N/A physical interaction ComPPI
RRM2 FAF2 25348397 N/A physical interaction ComPPI
RRM2 CSTF1 25348397 N/A physical interaction ComPPI
RRM2 NPLOC4 25348397 N/A physical interaction ComPPI
RRM2 ASNS 25348397 N/A physical interaction ComPPI
RRM2 DNAAF5 25348397 N/A physical interaction ComPPI
RRM2 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 PCM1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 MKS1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 CEP170 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 POC1A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 STIL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RRM2 ANAPC15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2 SDHAF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2 TMEM248 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRM2 SPAG9 25348397 N/A physical interaction ComPPI
RRM2 TRIM25 25348397 N/A physical interaction ComPPI
RRM2 HSPA4 25348397 N/A physical interaction ComPPI
RRM2 HSP90AA2P 25348397 N/A physical interaction ComPPI
RRM2 TSG101 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
RRM2 CDK1 14525934 22632967 24234451 25348397 9990288 phosphorylation reaction experimental interaction detection,protein kinase assay ComPPI,HPRD,IntAct
PPP2R5D RRM2 25348397 N/A physical interaction ComPPI
DDX19B RRM2 25348397 N/A physical interaction ComPPI
RRM2 RRM2 17726094 24234451 N/A molecular sieving IntAct
CDK2 RRM2 17693683 27898060 N/A N/A OmniPath
CDK1 RRM2 17924679 18669648 18767875 19276368 19413330 19415658 19664995 20058876 20097925 22632967 24667141 26602815 27898060 9990288 inhibition,stimulant N/A OmniPath

Visualization










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