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GENE：SERPINE1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SERPINE1
FullNmae serpin family E member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8583
EnsembleID ENSG00000106366
Uniprot P05121

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SERPINE1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SERPINE1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SERPINE1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SERPINE1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SERPINE1 cuproptosis 37243753 However, there are very few studies of cuproptosis in GC. In this paper, a prediction model related to cuproptosis was established and verified through data mining, and the six genes related to cuproptosis were ACLY, FGD6, SERPINE1, SPATA13, RANGAP1, and ADGRE5. genes related to cuproptosis

Go Annotation:

GeneSymbol Go id
SERPINE1 GO:0001525,GO:0002020,GO:0004867,GO:0004867,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005886,GO:0010469,GO:0010757,GO:0010757,GO:0010757,GO:0010757,GO:0010951,GO:0010951,GO:0014912,GO:0030194,GO:0030195,GO:0030336,GO:0031093,GO:0032757,GO:0033629,GO:0035491,GO:0042730,GO:0045766,GO:0048260,GO:0050729,GO:0050829,GO:0051918,GO:0051918,GO:0061044,GO:0061044,GO:0061045,GO:0062023,GO:0062023,GO:0062023,GO:0070062,GO:0071222,GO:0090026,GO:0090399,GO:0097180,GO:0097187,GO:1901331,GO:1902042,GO:1904090,GO:2000098,GO:2000352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SERPINE1 hsa:5054 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa04218 Cellular senescence - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
SERPINE1 hsa:5054 path:hsa05142 Chagas disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
WWTR1 SERPINE1 12807903 18280240 18617895 21666501 23708000 25502501 26192618 26711338 7782338 interaction type N/A ACSN
YAP1 SERPINE1 12807903 18280240 18617895 21666501 23708000 25502501 26192618 26711338 7782338 interaction type N/A ACSN
SERPINE1 PLG 11021826 20027185 25502501 26192618 interaction type N/A ACSN
SERPINE1 PLAU 11021826 20027185 25502501 26192618 interaction type N/A ACSN
HIF1A SERPINE1 15968405 23180781 physical association electrophoretic mobility supershift assay InnateDB
SMAD7 SERPINE1 17438144 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 SERPINE1 10092624 21625455 23180781 9606191 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
SMAD4 SERPINE1 10092624 19139564 23180781 9606191 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR SERPINE1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
CREB1 SERPINE1 20136501 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EPAS1 SERPINE1 15039136 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
HIF1A SERPINE1 11877282 14567996 17570486 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMAD3 SERPINE1 10557285 17761371 24330518 9765209 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
MYC SERPINE1 12695333 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
YBX1 SERPINE1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 SERPINE1 10880342 11251188 15039136 1634545 8342330 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TFAP2A SERPINE1 8342330 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
HLTF SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TBP SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SERPINE1 11402043 11559366 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SERPINE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ARNTL2 SERPINE1 22198637 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 SERPINE1 15217907 trascriptional regulation,stimulation inferred by curator TFlink
ESR2 SERPINE1 15217907 trascriptional regulation,stimulation inferred by curator TFlink
HSF1 SERPINE1 17259369 19401454 trascriptional regulation,stimulation inferred by curator TFlink
KLF10 SERPINE1 12173049 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 SERPINE1 11757833 12675842 15631825 trascriptional regulation,stimulation inferred by curator TFlink
NR4A1 SERPINE1 12506026 trascriptional regulation,stimulation inferred by curator TFlink
PARP1 SERPINE1 22159350 trascriptional regulation,stimulation inferred by curator TFlink
PPARA SERPINE1 12667383 15631825 trascriptional regulation,stimulation inferred by curator TFlink
PPARG SERPINE1 10073956 trascriptional regulation,stimulation inferred by curator TFlink
RELA SERPINE1 11757833 12675842 15631825 trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 SERPINE1 9765209 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SERPINE1 10880342 11251188 15039136 trascriptional regulation,stimulation inferred by curator TFlink
SRF SERPINE1 15514113 trascriptional regulation,stimulation inferred by curator TFlink
TGIF1 SERPINE1 19524896 trascriptional regulation,stimulation inferred by curator TFlink
USF1 SERPINE1 12235287 16902162 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F3 SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS1 SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARD SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 SERPINE1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000008A99 SERPINE1 22108519 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 SERPINE1 22108519 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001C11BC SERPINE1 21175428 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000157026 SERPINE1 21175428 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 SERPINE1 21282569 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C11BC SERPINE1 21175428 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000157026 SERPINE1 21175428 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000008A99 SERPINE1 22108519 25416803 26817521 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 SERPINE1 22108519 23312222 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 SERPINE1 21703006 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002152A8 SERPINE1 22012620 25170877 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000065D58 SERPINE1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F SERPINE1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 SERPINE1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 SERPINE1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SERPINE1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002D2333 SERPINE1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 SERPINE1 25416803 25554417 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000B59A2 SERPINE1 25416803 27216198 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SERPINE1 VTN 25361965 interaction type N/A PTMCode2
VTN SERPINE1 25361965 interaction type N/A PTMCode2
SERPINE1 IGFBP5 25361965 interaction type N/A PTMCode2
IGFBP5 SERPINE1 25361965 interaction type N/A PTMCode2
SERPINE1 ORM1 25361965 interaction type N/A PTMCode2
ORM1 SERPINE1 25361965 interaction type N/A PTMCode2
SERPINE1 LRP2 25361965 interaction type N/A PTMCode2
LRP2 SERPINE1 25361965 interaction type N/A PTMCode2
SERPINE1 MMP3 25361965 interaction type N/A PTMCode2
MMP3 SERPINE1 25361965 interaction type N/A PTMCode2
SERPINE1 F2 25361965 interaction type N/A PTMCode2
F2 SERPINE1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRT18 SERPINE1 14525934 15493875 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SGTA SERPINE1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SGTB SERPINE1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MMP3 SERPINE1 10967118 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LMNA SERPINE1 25348397 N/A physical interaction ComPPI
PITX1 SERPINE1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ELANE SERPINE1 14525934 25348397 7521069 N/A experimental interaction detection,in vitro ComPPI,HPRD
PSMA3 SERPINE1 25348397 N/A physical interaction ComPPI
PLG SERPINE1 11113116 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
F2 SERPINE1 10543954 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ACTN4 SERPINE1 14525934 15493875 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
SERPINE1 PLAT 14525934 2110366 22449964 24234451 25348397 3090045 8607113 N/A experimental interaction detection,physical interaction,in vitro,in vivo,comigration in gel electrophoresis ComPPI,HPRD,IntAct
SERPINE1 LRP1B 11384978 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SERPINE1 LRP1 14525934 15001579 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SERPINE1 UBQLN4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
SERPINE1 ORM1 11418606 14525934 16272158 24234451 25348397 27898060 colocalization,physical association two hybrid,experimental interaction detection,fluorescence-activated cell sorting,physical interaction,enzyme linked immunosorbent assay,in vitro,confocal microscopy,two hybrid ComPPI,HPRD,IntAct,OmniPath
SERPINE1 IGFBP5 14525934 25348397 27898060 9202242 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SERPINE1 LOX 25348397 N/A pull down ComPPI
SERPINE1 FBN1 25348397 N/A pull down ComPPI
SERPINE1 MFAP2 25348397 N/A pull down ComPPI
SERPINE1 FBLN5 25348397 N/A pull down ComPPI
SERPINE1 PLAU 14525934 2161846 22449964 24234451 25348397 2544876 3090045 N/A experimental interaction detection,physical interaction,comigration in gel electrophoresis ComPPI,HPRD,IntAct
SERPINE1 LPA 25348397 N/A physical interaction ComPPI
SERPINE1 NOS2 25348397 N/A physical interaction ComPPI
SERPINE1 UBQLN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SERPINE1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SERPINE1 HSD17B11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERPINE1 UBQLN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERPINE1 TLX3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VTN SERPINE1 11796824 12808446 14525934 24234451 25348397 8830783 9065424 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PSMB1 SERPINE1 25348397 N/A physical interaction ComPPI
LRP2 SERPINE1 14525934 8344937 N/A experimental interaction detection HPRD
SERPINE1 SERPINE1 10731421 14525934 N/A experimental interaction detection HPRD
KLK2 SERPINE1 10209959 14525934 N/A experimental interaction detection HPRD
TP53 SERPINE1 18431400 27898060 stimulant N/A OmniPath
KLK2 SERPINE1 10209959 27898060 inhibition N/A OmniPath

Visualization










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