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GENE：SETD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SETD2
FullNmae SET domain containing 2, histone lysine methyltransferase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18420
EnsembleID ENSG00000181555
Uniprot Q9BYW2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SETD2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SETD2 GO:0001525,GO:0001763,GO:0001843,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005694,GO:0005694,GO:0005737,GO:0006298,GO:0006355,GO:0006368,GO:0010038,GO:0010468,GO:0010508,GO:0010569,GO:0010793,GO:0014070,GO:0016279,GO:0018023,GO:0030900,GO:0032465,GO:0032727,GO:0034340,GO:0034728,GO:0035441,GO:0035987,GO:0043014,GO:0043279,GO:0045778,GO:0046872,GO:0046975,GO:0046975,GO:0046975,GO:0048332,GO:0048701,GO:0048863,GO:0048864,GO:0051607,GO:0060039,GO:0060669,GO:0060977,GO:0097198,GO:0097198,GO:0097676,GO:0140938,GO:0140955,GO:1902850,GO:1905634

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SETD2 hsa:29072 path:hsa00310 Lysine degradation - Homo sapiens (human)
SETD2 hsa:29072 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SETD2 SMAD3 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SETD2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SETD2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SETD2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SETD2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SETD2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SETD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A SETD2 18842833 19091749 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 SETD2 23622248 25416803 25714014 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,immunocytochemistry,clash,miRNA interference luciferase reporter assay TarBase
URS0000029EBD SETD2 23594994 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D SETD2 24983504 25416803 mrna cleavage,inhibition chromatin immunoprecipitation assay,miRNA interference luciferase reporter assay TarBase
URS000021D7C8 SETD2 25416803 27159677 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000075E2C3 SETD2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HTT SETD2 25361965 interaction type N/A PTMCode2
SETD2 HTT 25361965 interaction type N/A PTMCode2
TP53 SETD2 25361965 interaction type N/A PTMCode2
SETD2 TP53 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CBX8 SETD2 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ATXN1 SETD2 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HSPB8 SETD2 25348397 N/A physical interaction ComPPI
SIAH2 SETD2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD3 SETD2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CLK2 SETD2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
F9 SETD2 25348397 N/A physical interaction ComPPI
NXF2 SETD2 25348397 N/A physical interaction ComPPI
XPO1 SETD2 25348397 N/A physical interaction ComPPI
SOX2 SETD2 25348397 N/A physical interaction ComPPI
H3-4 SETD2 25348397 N/A physical interaction ComPPI
HTT SETD2 14525934 17500595 24234451 25348397 9700202 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
POLR2A SETD2 12381723 16118227 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EIF3I SETD2 25348397 N/A physical interaction ComPPI
AURKA SETD2 25348397 N/A physical interaction ComPPI
MDC1 SETD2 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
TRPC4AP SETD2 25348397 N/A physical interaction ComPPI
CIC SETD2 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
H3C1 SETD2 25348397 N/A physical interaction ComPPI
TRIM25 SETD2 25348397 N/A physical interaction ComPPI
ELAVL1 SETD2 25348397 N/A physical interaction ComPPI
HNRNPLL SETD2 25348397 N/A physical interaction ComPPI
LUC7L SETD2 25348397 N/A physical interaction ComPPI
RASSF8 SETD2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SETD2 IWS1 25348397 N/A physical interaction ComPPI
SETD2 TP53 25348397 N/A physical interaction ComPPI
SETD2 WDR37 25348397 N/A physical interaction ComPPI
SETD2 ARHGEF10 25348397 N/A physical interaction ComPPI
SETD2 SCARA3 25348397 N/A physical interaction ComPPI
SETD2 GAN 25348397 N/A physical interaction ComPPI
SETD2 RSBN1 25348397 N/A physical interaction ComPPI
SETD2 CPNE7 25348397 N/A physical interaction ComPPI
SETD2 PIP4K2A 25348397 N/A physical interaction ComPPI
SETD2 JMJD6 25348397 N/A physical interaction ComPPI
SETD2 SETD2 14525934 9700202 N/A two hybrid HPRD
NPM1 SETD2 24234451 30021884 physical association cross-linking study IntAct
CENPF SETD2 24234451 30021884 physical association cross-linking study IntAct
HAT1 SETD2 14761951 17880717 20953179 27898060 N/A N/A OmniPath
TXN SETD2 20347035 27898060 stimulant N/A OmniPath
SETD2 H3C1 18022353 27898060 stimulant N/A OmniPath

Visualization










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