GENE:SIK1
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | SIK1 |
FullNmae | salt inducible kinase 1 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:11142 |
EnsembleID | ENSG00000142178 |
Uniprot | P57059 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
SIK1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
SIK1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
SIK1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
SIK1 | anoikis | 19724060 | These findings suggest that SIK1 is a key upstream regulator of p53-dependent anoikis that may be targeted in tumorigenesis. | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
SIK1 | GO:0000287,GO:0000287,GO:0002028,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005737,GO:0006468,GO:0006468,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0035556,GO:0035556,GO:0035556,GO:0042826,GO:0043153,GO:0043276,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:0106310,GO:2000210 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
SIK1 | hsa:150094 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | SIK1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | SIK1 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | SIK1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | SIK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00002FC5B0 | SIK1 | 20371350 22473208 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
URS00001799A3 | SIK1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00003BBF48 | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000000C73C | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000521626 | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002075FA | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000042E1F | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000039E1E1 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000600E6 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000070CD2 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000346991 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000027080C | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041E949 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000508C13 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B3783 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000006F90B | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001E0AEA | SIK1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000419B5A | SIK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000209F04 | SIK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000160683 | SIK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000171CD1 | SIK1 | 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000007D64A | SIK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041CB9C | SIK1 | 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F0F49 | SIK1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000040EE1D | SIK1 | 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002C0FCB | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000315338 | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001C11BC | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000251D0B | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000031602A | SIK1 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004900F1 | SIK1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00005D986D | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000025EABA | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003A8BB2 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000080D0A | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000008AA34 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002C02E4 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000039A25B | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075B13F | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075AEA5 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004283FE | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000118224 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000037B2E0 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000319E1 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000496C56 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000000E601 | SIK1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000759FD9 | SIK1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS000076B539 | SIK1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00004F24A9 | SIK1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001A7F58 | SIK1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
STK11 | SIK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
SIK1 | NCOR2 | 22135298 | phosphorylation | N/A | PhosphoSite |
YWHAE | SIK1 | 25361965 | interaction type | N/A | PTMCode2 |
SIK1 | YWHAE | 25361965 | interaction type | N/A | PTMCode2 |
SIK1 | CRTC2 | 25361965 | interaction type | N/A | PTMCode2 |
CRTC2 | SIK1 | 25361965 | interaction type | N/A | PTMCode2 |
SIK1 | YWHAB | 25361965 | interaction type | N/A | PTMCode2 |
YWHAB | SIK1 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PITX1 | SIK1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
SIK2 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
NMNAT1 | SIK1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
PRKACA | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
VAPA | SIK1 | 14525934 25348397 9920726 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
YWHAZ | SIK1 | 14525934 16306228 24234451 25348397 | association | experimental interaction detection,pull down,physical interaction,in vitro,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
PRKAA1 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
CD247 | SIK1 | 24234451 24502978 25348397 | association | pull down | ComPPI,IntAct |
XPO1 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
YWHAE | SIK1 | 16306228 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
RNF2 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
STK11 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
MAP3K7 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
TAB2 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
HDAC5 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
SUPT5H | SIK1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
ELAVL1 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
UBE2E1 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
MESD | SIK1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
CRTC2 | SIK1 | 14525934 16306228 24234451 25348397 | phosphorylation reaction | experimental interaction detection,protein kinase assay,in vitro,in vivo | ComPPI,HPRD,IntAct |
SIK1 | RPL3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
SIK1 | GINS4 | 25348397 | N/A | physical interaction | ComPPI |
SIK1 | TIMM10 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
SIK1 | LHX8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
SIK1 | PRTFDC1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
GINS2 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
SIK3 | SIK1 | 25348397 | N/A | physical interaction | ComPPI |
SIK1 | CRTC2 | 15454081 16306228 16817901 18669648 27898060 | inhibition | N/A | OmniPath |
STK11 | SIK1 | 14976552 18348280 27898060 | stimulant | N/A | OmniPath |
SIK1 | IRS1 | 12351658 12624099 15199052 16099428 16129690 27898060 | N/A | N/A | OmniPath |
SIK1 | HDAC4 | 10958686 27898060 | N/A | N/A | OmniPath |
SIK1 | CRTC3 | 16817901 27898060 | inhibition | N/A | OmniPath |
SIK1 | CRTC1 | 16817901 17525332 18669648 27898060 | inhibition,stimulant | N/A | OmniPath |