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GENE：SIM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIM2
FullNmae SIM bHLH transcription factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10883
EnsembleID ENSG00000159263
Uniprot Q14190

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIM2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SIM2 GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0000981,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0006357,GO:0007399,GO:0009880,GO:0016604,GO:0030154,GO:0030324,GO:0046982

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SIM2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
MYC SIM2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SIM2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SIM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB SIM2 11404025 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000002569A SIM2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF SIM2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D SIM2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 SIM2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SIM2 ARNT2 25361965 interaction type N/A PTMCode2
ARNT2 SIM2 25361965 interaction type N/A PTMCode2
SIM2 ARNT 25361965 interaction type N/A PTMCode2
ARNT SIM2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTA SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
NUDCD3 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
FOXR2 SIM2 25348397 N/A physical interaction ComPPI
HSP90AB1 SIM2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
AIP SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSP90AA1 SIM2 25348397 N/A physical interaction ComPPI
STIP1 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PTGES3 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CACYBP SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
TTC1 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSPB1 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
BAG4 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PSMD2 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
MAGED1 SIM2 25348397 N/A physical interaction ComPPI
PRKN SIM2 14525934 15963499 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
STUB1 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
NUDC SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
ARIH1 SIM2 25348397 N/A physical interaction ComPPI
BAG2 SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
ARNT2 SIM2 25348397 N/A physical interaction ComPPI
SIM2 ARNT 11782478 14525934 14701734 25348397 27898060 9020169 9271372 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
SIM2 HSP90AA2P 25348397 N/A physical interaction ComPPI
SIM2 FOXN1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SIM2 MATR3 25348397 N/A physical interaction ComPPI
SIM2 FKBP5 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SIM2 MLF1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
FKBPL SIM2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct

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