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GENE：SLC3A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC3A2
FullNmae solute carrier family 3 member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11026
EnsembleID ENSG00000168003
Uniprot P08195

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC3A2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SLC3A2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SLC3A2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SLC3A2 GO:0001618,GO:0003723,GO:0003725,GO:0005294,GO:0005432,GO:0005515,GO:0005654,GO:0005765,GO:0005886,GO:0005886,GO:0005975,GO:0006816,GO:0006865,GO:0009925,GO:0009986,GO:0009986,GO:0015173,GO:0015173,GO:0015175,GO:0015175,GO:0015180,GO:0015180,GO:0015190,GO:0015190,GO:0015818,GO:0015820,GO:0015820,GO:0015821,GO:0015823,GO:0015823,GO:0015823,GO:0015824,GO:0015827,GO:0015827,GO:0015828,GO:0015829,GO:0016020,GO:0016020,GO:0016323,GO:0016323,GO:0016324,GO:0016324,GO:0016324,GO:0035725,GO:0042470,GO:0042803,GO:0043330,GO:0044225,GO:0045202,GO:0045296,GO:0046718,GO:0046982,GO:0070062,GO:0070161,GO:0070327,GO:0098713,GO:0140272,GO:1902024,GO:1903801,GO:1903801,GO:1903801,GO:1904273,GO:1904273,GO:1990184

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SLC3A2 hsa:6520 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
SLC3A2 hsa:6520 path:hsa04216 Ferroptosis - Homo sapiens (human)
SLC3A2 hsa:6520 path:hsa04974 Protein digestion and absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LGALS3 SLC3A2 18250477 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGFR SLC3A2 16799092 23180781 physical association pull down InnateDB
SLC7A6 SLC3A2 11507094 23180781 physical association anti tag coimmunoprecipitation InnateDB
SLC3A2 ITGB1 11507094 23180781 physical association anti tag coimmunoprecipitation InnateDB
ICAM1 SLC3A2 12716892 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 SLC3A2 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 SLC3A2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 SLC3A2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SLC3A2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SLC3A2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SLC3A2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 SLC3A2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC SLC3A2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TFAP2C SLC3A2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SLC3A2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SLC3A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SLC3A2 17023546 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SLC3A2 17023546 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SLC3A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN SLC3A2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 SLC3A2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AA464 SLC3A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 SLC3A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 SLC3A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000321A1A SLC3A2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F SLC3A2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SLC3A2 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 SLC3A2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
LGALS3 SLC3A2 18250477 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDC73 SLC3A2 25348397 N/A physical interaction ComPPI
MAD2L2 SLC3A2 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
VCP SLC3A2 25348397 N/A physical interaction ComPPI
KEAP1 SLC3A2 25348397 N/A physical interaction ComPPI
MCM2 SLC3A2 25348397 N/A physical interaction ComPPI
CD44 SLC3A2 21397861 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ERBB2 SLC3A2 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TXNIP SLC3A2 25348397 N/A physical interaction ComPPI
CD81 SLC3A2 24234451 25348397 30024968 association anti bait coimmunoprecipitation ComPPI,IntAct
CD9 SLC3A2 23289620 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
JUN SLC3A2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
ITGB1 SLC3A2 11507094 12181350 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
U2AF2 SLC3A2 25348397 N/A physical interaction ComPPI
CUL3 SLC3A2 25348397 N/A physical interaction ComPPI
NTRK1 SLC3A2 25348397 N/A physical interaction ComPPI
CANX SLC3A2 24234451 25348397 29568061 association pull down ComPPI,IntAct
CDH1 SLC3A2 25348397 N/A physical interaction ComPPI
VDAC1 SLC3A2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PKM SLC3A2 25348397 N/A physical interaction ComPPI
BRF2 SLC3A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARF6 SLC3A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EGFR SLC3A2 15657067 16799092 24189400 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,in vivo,tandem affinity purification ComPPI,IntAct
VAMP3 SLC3A2 25348397 N/A physical interaction ComPPI
VHL SLC3A2 25348397 N/A physical interaction ComPPI
PHB2 SLC3A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MMS19 SLC3A2 25348397 N/A physical interaction ComPPI
OCRL SLC3A2 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF3I SLC3A2 25348397 N/A physical interaction ComPPI
ITCH SLC3A2 25348397 N/A physical interaction ComPPI
NOS2 SLC3A2 25348397 N/A physical interaction ComPPI
ATXN3 SLC3A2 25348397 N/A physical interaction ComPPI
ATP2A2 SLC3A2 25348397 N/A physical interaction ComPPI
RAB9A SLC3A2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRA2B SLC3A2 25348397 N/A physical interaction ComPPI
CUL7 SLC3A2 25348397 N/A physical interaction ComPPI
SRSF3 SLC3A2 25348397 N/A physical interaction ComPPI
TRIM25 SLC3A2 25348397 N/A physical interaction ComPPI
PTBP1 SLC3A2 25348397 N/A physical interaction ComPPI
ACIN1 SLC3A2 25348397 N/A physical interaction ComPPI
HNRNPD SLC3A2 25348397 N/A physical interaction ComPPI
RPS6KB2 SLC3A2 25348397 N/A physical interaction ComPPI
GNAI2 SLC3A2 25348397 N/A physical interaction ComPPI
ESRRB SLC3A2 25348397 N/A physical interaction ComPPI
TGOLN2 SLC3A2 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
NEK6 SLC3A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BET1 SLC3A2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 SLC3A2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TES SLC3A2 25348397 N/A physical interaction ComPPI
TSC22D1 SLC3A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TLCD3A SLC3A2 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
SLC7A11 SLC3A2 11406111 12235164 25348397 27898060 N/A in vivo ComPPI,OmniPath
CTDSPL SLC3A2 25348397 N/A physical interaction ComPPI
ICAM1 SLC3A2 12716892 25348397 27898060 N/A in vivo ComPPI,OmniPath
CYLD SLC3A2 25348397 N/A physical interaction ComPPI
IFT27 SLC3A2 24234451 25348397 27173435 association anti tag coimmunoprecipitation ComPPI,IntAct
SLC3A2 SLC7A5 25348397 N/A physical interaction,in vitro ComPPI
SLC3A2 SLC7A7 25348397 27898060 9829974 9878049 N/A physical interaction,in vitro ComPPI,OmniPath
SLC3A2 SLC7A10 15458438 25348397 27898060 N/A in vivo ComPPI,OmniPath
SLC3A2 GSTK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC3A2 SLC7A5P1 25348397 N/A physical interaction ComPPI
SLC3A2 NDUFS3 25348397 N/A physical interaction ComPPI
SLC3A2 MRPS9 25348397 N/A physical interaction ComPPI
SLC3A2 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
SLC3A2 LGR4 25348397 N/A physical interaction ComPPI
SLC3A2 CCDC8 25348397 N/A physical interaction ComPPI
SLC3A2 BSG 25348397 N/A physical interaction ComPPI
SLC3A2 ZC3H18 25348397 N/A physical interaction ComPPI
SLC3A2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SLC3A2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SLC3A2 MBOAT1 25348397 N/A physical interaction ComPPI
SLC3A2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC3A2 ATOH1 25348397 N/A physical interaction ComPPI
SLC3A2 MTNR1B 24234451 25348397 26514267 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
SLC3A2 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC3A2 PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SLC3A2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SLC3A2 RNF169 21252943 24234451 25348397 association pull down ComPPI,IntAct
SLC3A2 LAMP1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
METTL14 SLC3A2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
SLC3A2 GPR37 24234451 28298427 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,ubiquitin reconstruction IntAct
CCR4 SLC3A2 24234451 28298427 physical association ubiquitin reconstruction IntAct
NPSR1 SLC3A2 24234451 28298427 physical association ubiquitin reconstruction IntAct
DAG1 SLC3A2 24234451 association cross-linking study IntAct
MAPT SLC3A2 24234451 26402096 association anti bait coimmunoprecipitation IntAct
SLC3A2 CCDC158 24234451 30021884 physical association cross-linking study IntAct
EGFR SLC3A2 16799092 24189400 24797263 27898060 N/A N/A OmniPath
CSNK2A1 SLC3A2 19065266 27898060 N/A N/A OmniPath

Visualization










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