GENE：SOX9
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SOX9 |
| FullNmae | SRY-box transcription factor 9 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11204 |
| EnsembleID | ENSG00000125398 |
| Uniprot | P48436 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SOX9 | pyroptosis | 35686454 | miR-96-5p silencing or USP7 overexpression reversed the inhibitory effect of SOX9 silencing on cardiomyocyte pyroptosis. | retulator signature |
| SOX9 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SOX9 | GO:0000122,GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0000987,GO:0000987,GO:0001228,GO:0001501,GO:0001502,GO:0001658,GO:0001708,GO:0001837,GO:0001894,GO:0001934,GO:0001942,GO:0002009,GO:0002053,GO:0002062,GO:0002062,GO:0002067,GO:0002683,GO:0003170,GO:0003179,GO:0003180,GO:0003188,GO:0003203,GO:0003413,GO:0003415,GO:0003430,GO:0003682,GO:0003700,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0006334,GO:0006338,GO:0006366,GO:0007010,GO:0007165,GO:0007173,GO:0007219,GO:0007283,GO:0007507,GO:0008013,GO:0008284,GO:0008584,GO:0008584,GO:0010463,GO:0010564,GO:0010628,GO:0010629,GO:0010634,GO:0014032,GO:0014036,GO:0014070,GO:0019100,GO:0019933,GO:0021780,GO:0030155,GO:0030279,GO:0030279,GO:0030282,GO:0030502,GO:0030850,GO:0030857,GO:0030858,GO:0030879,GO:0030903,GO:0030916,GO:0031018,GO:0032331,GO:0032332,GO:0032332,GO:0032332,GO:0032808,GO:0032991,GO:0034236,GO:0034504,GO:0035019,GO:0035622,GO:0042127,GO:0042981,GO:0043066,GO:0043066,GO:0043425,GO:0043491,GO:0043565,GO:0045662,GO:0045668,GO:0045732,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0046322,GO:0046533,GO:0048665,GO:0048709,GO:0050679,GO:0050679,GO:0050680,GO:0051216,GO:0051897,GO:0060008,GO:0060009,GO:0060018,GO:0060041,GO:0060070,GO:0060174,GO:0060221,GO:0060441,GO:0060509,GO:0060517,GO:0060532,GO:0060534,GO:0060575,GO:0060729,GO:0060784,GO:0061036,GO:0061046,GO:0061138,GO:0061145,GO:0061323,GO:0065003,GO:0070168,GO:0070168,GO:0070371,GO:0070384,GO:0070542,GO:0071260,GO:0071300,GO:0071347,GO:0071364,GO:0071504,GO:0071560,GO:0071773,GO:0072034,GO:0072089,GO:0072190,GO:0072193,GO:0072197,GO:0072289,GO:0085029,GO:0090090,GO:0090103,GO:0090184,GO:0090190,GO:0097065,GO:0097152,GO:0097157,GO:0098609,GO:1901203,GO:1902732,GO:1902894,GO:1904864,GO:1990837,GO:2000020,GO:2000138,GO:2000648,GO:2000741,GO:2000794,GO:2001054 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SOX9 | hsa:6662 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SOX9 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SOX9 | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| ETS1 | SOX9 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | SOX9 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SOX9 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPZ | SOX9 | 15908194 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| CEBPA | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SOX9 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | SOX9 | 17289023 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GLI1 | SOX9 | 17409199 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NR5A1 | SOX9 | 21412441 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SF1 | SOX9 | 21412441 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | SOX9 | 17289023 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | SOX9 | 17289023 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SRY | SOX9 | 11980203 19513096 19753101 21408189 21412441 22215485 22613723 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZBTB16 | SOX9 | 21547890 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | SOX9 | 17699775 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000237AF9 | SOX9 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000821E0 | SOX9 | 23752191 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000005A8ED | SOX9 | 24654627 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004F4657 | SOX9 | 22942087 23548270 23814265 25145279 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000204177 | SOX9 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | SOX9 | 24014021 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004AE8D3 | SOX9 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | SOX9 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | SOX9 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | SOX9 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | SOX9 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000254A6 | SOX9 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | SOX9 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048D44E | SOX9 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000214763 | SOX9 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BD367 | SOX9 | 25416803 27880941 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000034B6F5 | SOX9 | 25416803 26309565 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00004F507C | SOX9 | 25416803 28004116 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | SOX9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| GSK3B | SOX9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK14 | SOX9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| ROCK1 | SOX9 | 22135298 | phosphorylation | N/A | PhosphoSite |
| SOX9 | KPNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| KPNB1 | SOX9 | 25361965 | interaction type | N/A | PTMCode2 |
| SOX9 | NR5A1 | 25361965 | interaction type | N/A | PTMCode2 |
| NR5A1 | SOX9 | 25361965 | interaction type | N/A | PTMCode2 |
| SOX9 | DMRT1 | 25361965 | interaction type | N/A | PTMCode2 |
| DMRT1 | SOX9 | 25361965 | interaction type | N/A | PTMCode2 |
| SOX9 | CREB1 | 25361965 | interaction type | N/A | PTMCode2 |
| CREB1 | SOX9 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| NR5A1 | SOX9 | 12732652 14525934 25348397 27898060 9774680 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| FBXW7 | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| MAF | SOX9 | 12381733 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| CREBBP | SOX9 | 12732631 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RUNX2 | SOX9 | 17142326 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| SMAD2 | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| EP300 | SOX9 | 12732631 14525934 15623506 19828133 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| SMAD3 | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| GSK3B | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| KPNB1 | SOX9 | 11323423 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| HERC1 | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| HSPA1A | SOX9 | 11356186 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| HSPA1B | SOX9 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| SOX9 | MED12 | 12136106 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| SOX9 | TRAF2 | 12136106 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SOX9 | SPEN | 11331609 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SOX9 | CREB1 | 14525934 19113914 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SOX9 | SCX | 25348397 | N/A | physical interaction | ComPPI |
| SOX9 | CREB3L4 | 25348397 | N/A | physical interaction | ComPPI |
| SOX9 | ATP6V1H | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ZBTB7A | SOX9 | 25348397 | N/A | physical interaction | ComPPI |
| PRKACA | SOX9 | 15889150 27898060 | stimulant | N/A | OmniPath |
| WNT1 | SOX9 | 18495817 27898060 | stimulant | N/A | OmniPath |
| ROCK1 | SOX9 | 10805756 11120880 19470758 20039424 21818404 27898060 | stimulant | N/A | OmniPath |
| STK11 | SOX9 | 10805756 11120880 15889150 27898060 | N/A | N/A | OmniPath |
| PIAS1 | SOX9 | 16554309 27898060 | stimulant | N/A | OmniPath |