Gene Information gene info

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GENE：TJP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TJP1
FullNmae tight junction protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11827
EnsembleID ENSG00000104067
Uniprot Q07157

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TJP1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TJP1 GO:0002102,GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0005921,GO:0005923,GO:0005923,GO:0007043,GO:0008284,GO:0016323,GO:0030036,GO:0030054,GO:0030054,GO:0030335,GO:0031032,GO:0032991,GO:0034334,GO:0035633,GO:0042995,GO:0043066,GO:0043296,GO:0045177,GO:0045216,GO:0045216,GO:0045296,GO:0050839,GO:0051493,GO:0051497,GO:0070160,GO:0070160,GO:0071896,GO:0090557,GO:0090557,GO:0098609,GO:0150105,GO:0150105,GO:1901888,GO:1902396,GO:1903672,GO:1905605,GO:1905605,GO:2000049,GO:2000810

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TJP1 hsa:7082 path:hsa04520 Adherens junction - Homo sapiens (human)
TJP1 hsa:7082 path:hsa04530 Tight junction - Homo sapiens (human)
TJP1 hsa:7082 path:hsa04540 Gap junction - Homo sapiens (human)
TJP1 hsa:7082 path:hsa05110 Vibrio cholerae infection - Homo sapiens (human)
TJP1 hsa:7082 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
TJP1 hsa:7082 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TJP1 OCLN 17087658 23180781 physical association anti tag coimmunoprecipitation InnateDB
TJP1 TUBB 16944923 23180781 physical association gst pull down InnateDB
TJP1 VMP1 17724469 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF4 TJP1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
TJP1 SP3 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
TJP1 SP1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
TJP1 GATA6 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
TJP1 GATA1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TJP1 18535113 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 TJP1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TJP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TJP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TJP1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN TJP1 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TJP1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TJP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 TJP1 20580679 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001AFC71 TJP1 18162065 \N rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00001AFC71 TJP1 18162065 25416803 26692142 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000338542 TJP1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003D5391 TJP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D TJP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA TJP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 TJP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C5969 TJP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 TJP1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF TJP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 TJP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA TJP1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 TJP1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 TJP1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 TJP1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E TJP1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 TJP1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B TJP1 25416803 28153728 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
PIN1 TJP1 25348397 N/A physical interaction ComPPI
VIM TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TUBB TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ACTB TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PPP1CB TJP1 25348397 N/A physical interaction ComPPI
CLDN2 TJP1 10601346 14525934 22546605 24234451 25348397 colocalization experimental interaction detection,physical interaction,confocal microscopy ComPPI,HPRD,IntAct
STRN TJP1 25348397 N/A physical interaction ComPPI
KBTBD7 TJP1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLDN8 TJP1 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
IFI30 TJP1 25348397 N/A physical interaction ComPPI
OCLN TJP1 10575001 10601346 11700038 12169098 14525934 18662404 19017651 24234451 25348397 7798316 9792688 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
KHDRBS1 TJP1 25348397 N/A physical interaction ComPPI
FLNA TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
VAPA TJP1 25348397 N/A physical interaction ComPPI
ACTN4 TJP1 14525934 16944923 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy ComPPI,HPRD,IntAct
HSP90AA1 TJP1 25348397 N/A physical interaction ComPPI
ACTN1 TJP1 25348397 N/A physical interaction ComPPI
NTRK1 TJP1 25348397 N/A physical interaction ComPPI
CDH1 TJP1 25348397 N/A physical interaction ComPPI
CDH5 TJP1 18662404 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BTRC TJP1 25348397 N/A physical interaction ComPPI
PVR TJP1 17717529 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
MAGI3 TJP1 10748157 24234451 25348397 colocalization imaging technique ComPPI,IntAct
F11R TJP1 25348397 N/A physical interaction ComPPI
PLEC TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
HNRNPL TJP1 25348397 N/A physical interaction ComPPI
CFTR TJP1 17110338 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CEP135 TJP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
THOC5 TJP1 25348397 N/A physical interaction ComPPI
SPTAN1 TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PARD3 TJP1 25348397 N/A physical interaction ComPPI
PARD6A TJP1 25348397 N/A physical interaction ComPPI
CHM TJP1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8B TJP1 25348397 N/A physical interaction ComPPI
XPO1 TJP1 25348397 N/A physical interaction ComPPI
RNF168 TJP1 25348397 N/A physical interaction ComPPI
SSTR3 TJP1 19071123 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ODF2 TJP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DTNA TJP1 25348397 N/A physical interaction ComPPI
VAPB TJP1 25348397 N/A physical interaction ComPPI
EGFR TJP1 12708492 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TUBA1A TJP1 24234451 25348397 27291054 association pull down ComPPI,IntAct
YBX3 TJP1 25348397 N/A physical interaction ComPPI
PRKCI TJP1 25348397 N/A physical interaction ComPPI
RTN4 TJP1 25348397 N/A physical interaction ComPPI
CDC14A TJP1 25348397 N/A physical interaction ComPPI
CUL7 TJP1 25348397 N/A physical interaction ComPPI
TJP2 TJP1 10026224 10966866 14525934 24234451 24255178 25348397 7542259 colocalization experimental interaction detection,physical interaction,proximity-dependent biotin identification ComPPI,HPRD,IntAct
NOTCH2 TJP1 25348397 N/A physical interaction ComPPI
WWTR1 TJP1 20850437 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
ELAVL1 TJP1 25348397 N/A physical interaction ComPPI
CLDN1 TJP1 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TUBB4A TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GJA8 TJP1 12808044 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CLDN5 TJP1 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CLDN4 TJP1 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
JAM2 TJP1 12953056 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
JAM3 TJP1 25348397 N/A physical interaction ComPPI
KIRREL1 TJP1 12578837 12865409 14525934 22262837 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,x ray scattering ComPPI,HPRD,IntAct,OmniPath
CLDN7 TJP1 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CGN TJP1 10613913 11042084 12023291 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
CLDN6 TJP1 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TJP3 TJP1 25348397 N/A physical interaction ComPPI
RAE1 TJP1 25348397 N/A physical interaction ComPPI
NIN TJP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
KRT1 TJP1 25348397 N/A physical interaction ComPPI
CNTRL TJP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GRHPR TJP1 25348397 N/A physical interaction ComPPI
PAN2 TJP1 25348397 N/A physical interaction ComPPI
IFI16 TJP1 25348397 N/A physical interaction ComPPI
CEP152 TJP1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CTDSPL TJP1 25348397 N/A physical interaction ComPPI
DLST TJP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
KRT8 TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MYO1C TJP1 25348397 N/A physical interaction ComPPI
LATS2 TJP1 25348397 N/A physical interaction ComPPI
DEFA1 TJP1 25348397 N/A physical interaction ComPPI
NDUFV2 TJP1 25348397 N/A physical interaction ComPPI
GJA1 TJP1 14525934 16944923 24234451 25348397 9707407 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
TUBB3 TJP1 24234451 25348397 27291054 association pull down ComPPI,IntAct
UQCRB TJP1 25348397 N/A physical interaction ComPPI
ZUP1 TJP1 25348397 N/A physical interaction ComPPI
KRT10 TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ZPR1 TJP1 25348397 N/A physical interaction ComPPI
TUBA1C TJP1 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
NDUFS6 TJP1 25348397 N/A physical interaction ComPPI
SIRT7 TJP1 25348397 N/A physical interaction ComPPI
KSR1 TJP1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
RAPGEF2 TJP1 25348397 N/A physical interaction ComPPI
CRYBA4 TJP1 25348397 N/A physical interaction ComPPI
AFDN TJP1 23750010 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
BCAR1 TJP1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
TJP1 PTPN14 12808048 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TJP1 CLDN3 10601346 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TJP1 GJD3 12154091 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TJP1 HSP90AA2P 25348397 N/A physical interaction ComPPI
TJP1 ANXA6 16944923 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TJP1 SCO2 25348397 N/A physical interaction ComPPI
TJP1 SUGP1 25348397 N/A physical interaction ComPPI
TJP1 VMP1 17724469 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
TJP1 OBSL1 25348397 N/A physical interaction ComPPI
TJP1 CCDC8 25348397 N/A physical interaction ComPPI
TJP1 LUZP4 25348397 N/A physical interaction ComPPI
TJP1 MAGIX 25348397 N/A physical interaction ComPPI
TJP1 RNF166 25348397 N/A physical interaction ComPPI
TJP1 WDR3 25348397 N/A physical interaction ComPPI
TJP1 B9D2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TJP1 CEP104 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TJP1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TJP1 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TJP1 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TJP1 SASS6 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TJP1 MYO19 25348397 N/A physical interaction ComPPI
TJP1 CCDC102B 25348397 N/A physical interaction ComPPI
TJP1 SUN2 25348397 N/A physical interaction ComPPI
TJP1 CLEC14A 25348397 N/A physical interaction ComPPI
TJP1 CDC42BPB 21240187 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
TJP1 TACSTD2 20651236 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
TJP1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
TJP1 TJP1 10026224 10966866 14525934 N/A experimental interaction detection HPRD
GRIN2D TJP1 10862698 14525934 N/A experimental interaction detection HPRD
GJB3 TJP1 12154091 14525934 N/A experimental interaction detection HPRD
GJC1 TJP1 11557048 12064590 14525934 N/A experimental interaction detection HPRD
GRIN1 TJP1 10862698 14525934 N/A experimental interaction detection HPRD
TJP1 CTNNA1 14525934 9214391 N/A experimental interaction detection HPRD
TJP1 ARVCF 14525934 15456900 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
TJP1 TRPC4 14525934 15540229 N/A experimental interaction detection HPRD
CLDN16 TJP1 14525934 14628289 N/A experimental interaction detection HPRD
TJP1 ACTA1 14525934 9214391 N/A experimental interaction detection HPRD
TJP1 GJA3 12808044 14525934 N/A experimental interaction detection HPRD
CNKSR2 TJP1 14525934 16637659 N/A experimental interaction detection HPRD
TJP1 CTTN 11018051 14525934 9792678 N/A experimental interaction detection HPRD
L1TD1 TJP1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
TJP1 UBN1 18823282 27898060 N/A N/A OmniPath
TJP1 GJA1 16944923 27898060 9707407 N/A N/A OmniPath
TJP1 GJC1 11313345 11557048 12064590 27898060 N/A N/A OmniPath
PTPRJ TJP1 19332538 27898060 N/A N/A OmniPath

Visualization










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