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GENE：TLE1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLE1
FullNmae TLE family member 1, transcriptional corepressor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11837
EnsembleID ENSG00000196781
Uniprot Q04724

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLE1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLE1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLE1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLE1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLE1 anoikis 22952044 In the present study, we found that TLE1 is a regulator of anoikis in normal mammary epithelial and breast carcinoma cells. retulator signature

Go Annotation:

GeneSymbol Go id
TLE1 GO:0003714,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005829,GO:0007165,GO:0009887,GO:0010628,GO:0016055,GO:0030178,GO:0042802,GO:0043124,GO:0045892,GO:0090090,GO:0140297,GO:1990907,GO:2000811

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLE1 hsa:7088 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
TLE1 hsa:7088 path:hsa04330 Notch signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLE1 CCL18 16169070 23180781 physical association two hybrid InnateDB
LEF1 TLE1 23331499 9751710 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TLE1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 TLE1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 TLE1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TLE1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TLE1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 TLE1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C TLE1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TLE1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TLE1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TLE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HHEX TLE1 15187083 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002B2B5C TLE1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00003D5391 TLE1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 TLE1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005194EC TLE1 25416803 25844602 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 TLE1 22135298 phosphorylation N/A PhosphoSite
UTY TLE1 25361965 interaction type N/A PTMCode2
TLE1 UTY 25361965 interaction type N/A PTMCode2
CTBP1 TLE1 25361965 interaction type N/A PTMCode2
TLE1 CTBP1 25361965 interaction type N/A PTMCode2
HES1 TLE1 25361965 interaction type N/A PTMCode2
TLE1 HES1 25361965 interaction type N/A PTMCode2
RUNX1 TLE1 25361965 interaction type N/A PTMCode2
TLE1 RUNX1 25361965 interaction type N/A PTMCode2
HHEX TLE1 25361965 interaction type N/A PTMCode2
TLE1 HHEX 25361965 interaction type N/A PTMCode2
FOXA2 TLE1 25361965 interaction type N/A PTMCode2
TLE1 FOXA2 25361965 interaction type N/A PTMCode2
HES6 TLE1 25361965 interaction type N/A PTMCode2
TLE1 HES6 25361965 interaction type N/A PTMCode2
SIX6 TLE1 25361965 interaction type N/A PTMCode2
TLE1 SIX6 25361965 interaction type N/A PTMCode2
HNF1A TLE1 25361965 interaction type N/A PTMCode2
TLE1 HNF1A 25361965 interaction type N/A PTMCode2
CTNNB1 TLE1 25361965 interaction type N/A PTMCode2
TLE1 CTNNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 TLE1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NUDT21 TLE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MORF4L2 TLE1 12391155 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HOXA1 TLE1 25348397 N/A physical interaction ComPPI
TMSB4X TLE1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CDKN1A TLE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SAT1 TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CRCT1 TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLB TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TK1 TLE1 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SNRPG TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
VENTX TLE1 25348397 N/A physical interaction ComPPI
HHEX TLE1 14525934 15187083 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
QPRT TLE1 25348397 N/A physical interaction ComPPI
FOXB1 TLE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SMN1 TLE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2L1 TLE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
H4C1 TLE1 24234451 24596249 25348397 N/A far western blotting ComPPI,IntAct
GRB7 TLE1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 FOXG1 11238932 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TLE1 KDM6A 14525934 25348397 9854018 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TLE1 RUNX3 24234451 25348397 9751710 physical association beta galactosidase complementation,two hybrid,far western blotting,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
TLE1 FOXA2 10748198 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TLE1 IL6ST 12030375 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TLE1 TLE2 14525934 25348397 9874198 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TLE1 PRDM1 14525934 25348397 9887105 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TLE1 SIX3 12441302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TLE1 HES6 11551980 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
TLE1 GSTM4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 PEX2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 RPA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 HSPE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 CCL18 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 EIF2S2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 PSMD11 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 ARL3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 HLA-DQA1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 PCDHA4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 FXYD6 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TLE1 FUBP1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TLE1 RNF10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 BTBD2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 ZFP64 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 POLE2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 MPHOSPH6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 CELF3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 MSX1 14525934 16002402 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLE1 PFN1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 DAZAP2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 DLEU1 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TLE1 HES1 14525934 25348397 8687460 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TLE1 SIX2 12441302 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TLE1 SIX6 12441302 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TLE1 HNF1A 10209158 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TLE1 RUNX1 14525934 25348397 9751710 N/A beta galactosidase complementation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TLE1 TLE5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TLE1 SNRPGP15 25348397 N/A physical interaction ComPPI
TLE1 ATN1 14525934 16169070 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
TLE1 UTY 14525934 25348397 9854018 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
TLE1 RELA 25348397 N/A physical interaction ComPPI
TLE1 CTNNB1 25348397 N/A physical interaction ComPPI
TLE1 LEF1 14525934 24234451 25348397 9751710 N/A experimental interaction detection,far western blotting,physical interaction,two hybrid ComPPI,HPRD,IntAct
TLE1 UBTF 20160071 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TLE1 RUNX2 20160071 24234451 25348397 27898060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
TLE1 EN1 16571670 18611861 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TLE1 HDAC1 22439931 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TLE1 NKX2-5 25348397 N/A physical interaction ComPPI
TLE1 FOXA1 25348397 N/A physical interaction ComPPI
TLE1 FOXA3 25348397 N/A physical interaction ComPPI
TLE1 TLX2 25348397 N/A physical interaction ComPPI
TLE1 MSX2 25348397 N/A physical interaction ComPPI
TLE1 PAX9 25348397 N/A physical interaction ComPPI
TLE1 TLX3 25348397 N/A physical interaction ComPPI
TLE1 BARHL1 25348397 N/A physical interaction ComPPI
TLE1 CUL4B 17041588 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TLE1 SIRT1 17680780 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
TLE1 GSK3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 RAP1B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 RCC1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 KIAA0408 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 TSC22D1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 HESX1 11731482 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TLE1 NOD2 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
TLE1 ESRRG 25348397 N/A physical interaction ComPPI
TLE1 PROP1 25348397 N/A physical interaction ComPPI
TLE1 TLX1 25348397 N/A physical interaction ComPPI
TLE1 TCF3 25348397 N/A physical interaction ComPPI
TLE1 SS18 25348397 N/A physical interaction ComPPI
TLE1 SSX2 25348397 N/A physical interaction ComPPI
TLE1 EZH2 22439931 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TLE1 APH1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TLE1 TCF4 24234451 24596249 25348397 N/A fluorescence polarization spectroscopy,physical interaction ComPPI,IntAct
TLE1 STARD7 25348397 N/A physical interaction ComPPI
TLE1 TBX20 25348397 N/A physical interaction ComPPI
TLE1 FGL1 25348397 N/A physical interaction ComPPI
TLE1 PLSCR4 25348397 N/A physical interaction ComPPI
TLE1 TLE4 25348397 N/A physical interaction ComPPI
TLE1 RIPPLY1 25348397 N/A physical interaction ComPPI
TLE1 TLE3 25348397 N/A physical interaction ComPPI
TLE1 RIPPLY2 25348397 N/A physical interaction ComPPI
TLE1 HLX 25348397 N/A physical interaction ComPPI
TLE1 TNNI2 25348397 N/A physical interaction ComPPI
TLE1 HEY1 25348397 N/A physical interaction ComPPI
TLE1 TRIM25 25348397 N/A physical interaction ComPPI
TLE1 HIPK2 15896780 24234451 25348397 physical association pull down ComPPI,IntAct
TLE1 RERE 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TLE1 MECOM 25348397 N/A beta galactosidase complementation ComPPI
TLE1 RUNX1T1 25348397 N/A beta galactosidase complementation ComPPI
TLE1 VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TLE1 HDAC3 21251616 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TLE1 EED 22439931 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TLE1 SUZ12 22439931 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB1 TLE1 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ARL4D TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SIX1 TLE1 12441302 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PAFAH1B3 TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SERPINB9 TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATF2 TLE1 22439931 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERH TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TLE1 CDK1 12397081 14525934 N/A experimental interaction detection HPRD
TLE1 TLE1 14525934 24234451 24596249 9874198 N/A molecular sieving,x-ray crystallography,x ray scattering,two hybrid HPRD,IntAct
GSC TLE1 16762837 27898060 N/A N/A OmniPath
LEF1 TLE1 15768032 27898060 9751710 stimulant N/A OmniPath
CSNK2A1 TLE1 15367661 22354967 24270405 27898060 stimulant N/A OmniPath

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