GENE：TLE4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TLE4 |
| FullNmae | TLE family member 4, transcriptional corepressor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11840 |
| EnsembleID | ENSG00000106829 |
| Uniprot | Q04727 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TLE4 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TLE4 | GO:0000122,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0008150,GO:0016055,GO:0090090,GO:0140297,GO:1990830,GO:1990907 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TLE4 | hsa:7091 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| TLE4 | hsa:7091 | path:hsa04330 | Notch signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TLE4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | TLE4 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | TLE4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | TLE4 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TLE4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | TLE4 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | TLE4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | TLE4 | 20584899 | rna interference,inhibition | experimental interaction detection | miRSponge |
| URS0000338542 | TLE4 | 19193853 20584899 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection | TarBase |
| URS000039A25B | TLE4 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000237AF9 | TLE4 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000021D7C8 | TLE4 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000003ABC4 | TLE4 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000A07C1 | TLE4 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000AA464 | TLE4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000170CF4 | TLE4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000040EE1D | TLE4 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | TLE4 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | TLE4 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| OTX2 | TLE4 | 25361965 | interaction type | N/A | PTMCode2 |
| TLE4 | OTX2 | 25361965 | interaction type | N/A | PTMCode2 |
| PAX5 | TLE4 | 25361965 | interaction type | N/A | PTMCode2 |
| TLE4 | PAX5 | 25361965 | interaction type | N/A | PTMCode2 |
| CTNNB1 | TLE4 | 25361965 | interaction type | N/A | PTMCode2 |
| TLE4 | CTNNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VENTX | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| QPRT | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| FOXB1 | TLE4 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ZMYND19 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| TLE1 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| TLE3 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| LIG4 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| PRMT5 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| CCDC183 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| WDR77 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| CCT7 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| TLE5 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| TNNI2 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| PPM1B | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| TLE2 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| SRPK2 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| BRCA1 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| CUX1 | TLE4 | 25348397 | N/A | physical interaction | ComPPI |
| POU2F2 | TLE4 | 16103132 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| CUX1 | TLE4 | 19332113 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TLE4 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | TBX20 | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | EIPR1 | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | RIPPLY1 | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | RIPPLY2 | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | HLX | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | ARMC8 | 25348397 | N/A | physical interaction | ComPPI |
| TLE4 | MKLN1 | 25348397 | N/A | physical interaction | ComPPI |
| PAX5 | TLE4 | 10811620 12153506 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| TLE4 | PAX2 | 25631048 27898060 | inhibition | N/A | OmniPath |