Gene Information gene info

GENE:TLR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLR2
FullNmae toll like receptor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11848
EnsembleID ENSG00000137462
Uniprot O60603

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLR2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TLR2 GO:0001530,GO:0001540,GO:0001540,GO:0001666,GO:0001774,GO:0001875,GO:0002224,GO:0002224,GO:0002224,GO:0004888,GO:0005515,GO:0005737,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0006691,GO:0006915,GO:0006954,GO:0006955,GO:0007165,GO:0007252,GO:0007612,GO:0008285,GO:0009636,GO:0009986,GO:0010628,GO:0014005,GO:0030177,GO:0030667,GO:0030670,GO:0031663,GO:0032289,GO:0032570,GO:0032722,GO:0032728,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032755,GO:0032757,GO:0032757,GO:0032760,GO:0032868,GO:0034134,GO:0035325,GO:0035354,GO:0035354,GO:0035355,GO:0038023,GO:0038124,GO:0038187,GO:0042495,GO:0042496,GO:0042497,GO:0042497,GO:0042802,GO:0042834,GO:0042995,GO:0043235,GO:0044297,GO:0044877,GO:0045087,GO:0045087,GO:0045121,GO:0045944,GO:0046209,GO:0048714,GO:0050135,GO:0050729,GO:0050729,GO:0050765,GO:0050830,GO:0051092,GO:0051607,GO:0051770,GO:0051964,GO:0061809,GO:0070542,GO:0071221,GO:0071223,GO:0071223,GO:0071346,GO:0071726,GO:0071727,GO:1901224,GO:1903974,GO:1904466

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLR2 hsa:7097 path:hsa04145 Phagosome - Homo sapiens (human)
TLR2 hsa:7097 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
TLR2 hsa:7097 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
TLR2 hsa:7097 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05132 Salmonella infection - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05134 Legionellosis - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05140 Leishmaniasis - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05142 Chagas disease - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05144 Malaria - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05146 Amoebiasis - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05152 Tuberculosis - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05161 Hepatitis B - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05162 Measles - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
TLR2 hsa:7097 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNG TLR2 10485906 11489965 11579131 11672593 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16267105 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
HMGB1 TLR2 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
MYD88 TLR2 16482509 16893894 17126326 19717524 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid InnateDB
TLR10 TLR2 15728506 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGFR TLR2 17126326 23180781 physical association anti tag coimmunoprecipitation InnateDB
TOLLIP TLR2 11751856 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
LY96 TLR2 11160242 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 IRAK1 10395652 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAC1 TLR2 11101877 23180781 physical association gst pull down InnateDB
TLR2 SFTPA1 11724772 23180781 physical association far western blotting,solid phase assay InnateDB
RIPK2 TLR2 11894098 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 CD14 10395652 11986301 23180781 physical association anti tag coimmunoprecipitation,solid phase assay InnateDB
TLR1 TLR2 12077222 16848791 22673208 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
HRAS TLR2 15007072 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3R1 TLR2 15007072 18836450 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIP6 TLR2 15657077 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 SFTPD 16834340 23180781 physical association solid phase assay InnateDB
TLR2 PRKCZ 16925784 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TLR2 12471095 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 PSMD2 16482509 23180781 physical association two hybrid InnateDB
TLR2 HSP90B1 11584270 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD44 TLR2 18322236 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN6 TLR2 18836450 23180781 physical association anti tag coimmunoprecipitation InnateDB
CLEC7A TLR2 18373632 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 CYBB 19265148 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 NEU1 19430901 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TIRAP 19717524 22673208 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
TLR2 HLA-DRA 20098705 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TLR1 20348427 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 MYD88 20348427 22673208 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TLR2 TLR10 20348427 23180781 physical association anti tag coimmunoprecipitation InnateDB
TP53 TLR2 21483755 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 EEF2 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 YWHAQ 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 HSPA9 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TFG 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 RPS27A 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 DHX8 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TUBB2A 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 VIM 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 UBA1 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 HSPA8 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TUBB 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 HSP90AB1 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 EEF1A1 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 TUBB4B 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 MARCKSL1 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 CCT3 21827211 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR2 DCN 22087031 23180781 physical association pull down InnateDB
CIRBP TLR2 23180781 24097189 physical association surface plasmon resonance array InnateDB
SNAPIN TLR2 22523426 23180781 physical association comigration in gel electrophoresis InnateDB
LYN TLR2 23180781 26055819 physical association anti tag coimmunoprecipitation InnateDB
TLR2 PIK3R1 23180781 26055819 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
MAPK8IP3 TLR2 20005715 interaction type N/A PSP
PIK3R1 TLR2 20005715 interaction type N/A PSP
TOLLIP TLR2 20005715 interaction type N/A PSP
MAPK8IP3 TLR2 20005715 20005715 N/A N/A SignaLink
PIK3R1 TLR2 15007072 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TLR2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
HIF1A TLR2 18159247 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
FOXP3 TLR2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 TLR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TLR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TLR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TLR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TLR2 12686724 19779021 trascriptional regulation,stimulation inferred by curator TFlink
RELA TLR2 12686724 19779021 trascriptional regulation,stimulation inferred by curator TFlink
SP1 TLR2 18423053 18583567 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TLR2 18423053 18583567 trascriptional regulation,stimulation inferred by curator TFlink
SP3 TLR2 N/A trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TLR2 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 TLR2 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 TLR2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFBE3 TLR2 20375304 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000006FDD4 TLR2 22105995 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 TLR2 20375304 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 TLR2 22105995 25416803 28078022 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 TLR2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000600E6 TLR2 17242205 25416803 mrna cleavage,inhibition array technology TarBase
URS000008931A TLR2 24242044 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000008A99 TLR2 25416803 26722463 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001CC864 TLR2 25416803 28327409 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
FBP1 TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ANP32B TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TGFB1 TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RAC1 TLR2 11101877 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
HRAS TLR2 14525934 15496409 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3R1 TLR2 14525934 15007072 23247210 24234451 25348397 physical association experimental interaction detection,fluorescent resonance energy transfer,in vitro ComPPI,HPRD,IntAct
CREBBP TLR2 25348397 N/A physical interaction ComPPI
BGN TLR2 24234451 24480070 25348397 N/A microscale thermophoresis ComPPI,IntAct
IRF3 TLR2 25348397 N/A physical interaction ComPPI
AP1M1 TLR2 25348397 N/A physical interaction ComPPI
HSP90B1 TLR2 11912201 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TIRAP TLR2 17258210 24234451 25348397 physical association physical interaction,mammalian protein protein interaction trap ComPPI,IntAct
MAP2K1 TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAPK8IP3 TLR2 12941697 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STAT5A TLR2 25348397 N/A physical interaction ComPPI
TRIP6 TLR2 14525934 15657077 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HMGB1 TLR2 14525934 16267105 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK1 TLR2 10395652 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SFTPA1 TLR2 11724772 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EGFR TLR2 17126326 24234451 24658140 25348397 physical association anti bait coimmunoprecipitation,ubiquitin reconstruction,physical interaction ComPPI,IntAct
TLR2 TLR1 12077222 14525934 23155421 24234451 25348397 physical association experimental interaction detection,fluorescent resonance energy transfer,physical interaction,tox-r dimerization assay,in vivo ComPPI,HPRD,IntAct
TLR2 LY96 25348397 N/A physical interaction,in vivo ComPPI
TLR2 TLR6 12077222 14525934 23155421 24234451 25348397 physical association cosedimentation in solution,experimental interaction detection,fluorescent resonance energy transfer,tox-r dimerization assay,in vivo ComPPI,HPRD,IntAct
TLR2 TOLLIP 11751856 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TLR2 MYD88 14525934 16293622 16482509 17126326 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
TLR2 RIPK2 11894098 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLR2 TLR10 14525934 15728506 23155421 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,tox-r dimerization assay,in vivo ComPPI,HPRD,IntAct
TLR2 TICAM1 12471095 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLR2 CD14 10395652 14525934 18765807 24234451 25348397 N/A experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo ComPPI,HPRD,IntAct
TLR2 CLEC4M 25348397 N/A physical interaction ComPPI
TLR2 CLEC7A 25348397 N/A physical interaction ComPPI
TLR2 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
TLR2 TMEM214 25348397 N/A physical interaction ComPPI
TLR2 ACVR2A 25348397 N/A physical interaction ComPPI
TLR2 BMPR1A 25348397 N/A physical interaction ComPPI
TLR2 ITPRIP 25348397 N/A physical interaction ComPPI
TLR2 USP33 25348397 N/A physical interaction ComPPI
TLR2 STK11IP 25348397 N/A physical interaction ComPPI
TLR2 LGR4 25348397 N/A physical interaction ComPPI
TLR2 CXCR4 18765807 20802527 24234451 25348397 association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
TLR2 AKT1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TLR2 HEMGN 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TLR2 NANS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TLR2 STX17 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TLR2 TMOD1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TLR2 SIGLEC9 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
SIGLEC5 TLR2 24234451 25187624 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
TLR2 TLR2 23155421 24234451 physical association cosedimentation in solution,fluorescence technology,tox-r dimerization assay IntAct
SNAPIN TLR2 22523426 27898060 N/A N/A OmniPath
TLR2 EGFR 17126326 24658140 25402006 27898060 N/A N/A OmniPath
TICAM1 TLR2 12471095 27898060 N/A N/A OmniPath
RIPK2 TLR2 11894098 27898060 N/A N/A OmniPath
HRAS TLR2 15007072 15496409 27898060 N/A N/A OmniPath
TLR2 TICAM2 20072711 27898060 stimulant N/A OmniPath
TLR2 HSP90B1 11584270 11912201 27898060 N/A N/A OmniPath
TLR2 CLEC7A 18373632 27898060 N/A N/A OmniPath
TLR2 TLR10 15728506 20348427 27898060 N/A N/A OmniPath
TLR10 TLR2 15728506 20348427 27898060 N/A N/A OmniPath
TLR2 MYD88 16293622 16482509 16798732 16893894 17126326 19717524 20348427 22673208 27898060 stimulant N/A OmniPath
TLR2 PTPN6 18836450 27898060 N/A N/A OmniPath
TLR2 RAC1 11101877 27898060 stimulant N/A OmniPath
TLR2 PRKCZ 16925784 27898060 N/A N/A OmniPath
PRKCZ TLR2 16925784 27898060 N/A N/A OmniPath
TLR2 PIK3R1 15007072 18836450 23247210 27898060 N/A N/A OmniPath
PIK3R1 TLR2 15007072 18836450 23247210 27898060 N/A N/A OmniPath
VCAN TLR2 19122641 27898060 N/A N/A OmniPath
CD14 TLR2 10395652 11986301 18765807 27898060 stimulant N/A OmniPath
TLR2 TIRAP 17258210 18221795 19717524 22673208 27898060 stimulant N/A OmniPath
TLR2 IRAK1 10395652 27898060 N/A N/A OmniPath
IRAK1 TLR2 10395652 27898060 stimulant N/A OmniPath
SFTPD TLR2 16834340 27898060 N/A N/A OmniPath
SFTPA1 TLR2 11724772 27898060 N/A N/A OmniPath
CIRBP TLR2 24097189 27898060 N/A N/A OmniPath
TLR2 CD44 18322236 27898060 N/A N/A OmniPath
TRIP6 TLR2 15657077 27898060 N/A N/A OmniPath
DCN TLR2 22087031 27898060 N/A N/A OmniPath
TLR2 TLR6 12077222 16455995 27898060 N/A N/A OmniPath
TLR6 TLR2 12077222 16455995 27898060 N/A N/A OmniPath
TLR2 CYBB 19265148 27898060 N/A N/A OmniPath
TLR2 TOLLIP 11751856 27898060 stimulant N/A OmniPath
TOLLIP TLR2 11751856 27898060 N/A N/A OmniPath
TLR2 HLA-DRA 20098705 27898060 N/A N/A OmniPath
TLR2 PSMD2 16482509 27898060 N/A N/A OmniPath
NEU1 TLR2 19430901 27898060 N/A N/A OmniPath
TLR1 TLR2 12077222 16455995 16848791 20348427 22673208 27898060 N/A N/A OmniPath
TLR2 LY96 11160242 27898060 N/A N/A OmniPath
LY96 TLR2 11160242 27898060 N/A N/A OmniPath
BGN TLR2 16025156 24480070 27898060 N/A N/A OmniPath
ZG16B TLR2 20802527 27898060 N/A N/A OmniPath
RNASE2 TLR2 18195069 27898060 stimulant N/A OmniPath

Visualization