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GENE：TNF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNF
FullNmae tumor necrosis factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11892
EnsembleID ENSG00000232810
Uniprot P01375

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNF pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNF pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TNF parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNF necroptosis 27383048 At present, the most informative studies about necroptosis derive from the tumor necrosis factor (TNF)-triggered system. The initiation of TNF-induced necroptosis requires the kinase activity of receptor-interacting protein 1 and 3 (RIP1 and RIP3). retulator signature
TNF necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TNF immunogenic 38411755 A total of 57 ICD-related genes were selected from the literature. retulator signature
TNF cuproptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNF autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNF apoptosis 9695819 Tumour necrosis factor (TNF) is an inflammatory cytokine possessing a unique property: it can induce cells to undergo apoptosis. retulator signature
TNF apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TNF GO:0000122,GO:0000976,GO:0001666,GO:0001774,GO:0001774,GO:0001819,GO:0001891,GO:0001934,GO:0001937,GO:0002020,GO:0002037,GO:0002281,GO:0002439,GO:0002523,GO:0002637,GO:0002719,GO:0002876,GO:0002925,GO:0003009,GO:0003085,GO:0005125,GO:0005125,GO:0005164,GO:0005164,GO:0005164,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005886,GO:0005886,GO:0006006,GO:0006919,GO:0006954,GO:0006959,GO:0007249,GO:0007254,GO:0007623,GO:0008625,GO:0008625,GO:0008625,GO:0008630,GO:0009410,GO:0009615,GO:0009651,GO:0009750,GO:0009897,GO:0009986,GO:0009986,GO:0010459,GO:0010573,GO:0010628,GO:0010628,GO:0010628,GO:0010628,GO:0010629,GO:0010629,GO:0010888,GO:0014823,GO:0019722,GO:0030198,GO:0030316,GO:0030730,GO:0030866,GO:0031334,GO:0031622,GO:0031642,GO:0031667,GO:0032715,GO:0032722,GO:0032724,GO:0032729,GO:0032731,GO:0032741,GO:0032755,GO:0032755,GO:0032757,GO:0032757,GO:0032757,GO:0033138,GO:0033138,GO:0033209,GO:0033209,GO:0033209,GO:0034116,GO:0034138,GO:0035509,GO:0035900,GO:0036005,GO:0038177,GO:0042311,GO:0042531,GO:0042802,GO:0042802,GO:0043025,GO:0043065,GO:0043065,GO:0043068,GO:0043122,GO:0043123,GO:0043123,GO:0043123,GO:0043123,GO:0043154,GO:0043242,GO:0043243,GO:0043280,GO:0043406,GO:0043410,GO:0043491,GO:0043507,GO:0043525,GO:0043537,GO:0045071,GO:0045121,GO:0045429,GO:0045471,GO:0045598,GO:0045599,GO:0045662,GO:0045668,GO:0045672,GO:0045732,GO:0045760,GO:0045785,GO:0045840,GO:0045892,GO:0045893,GO:0045930,GO:0045944,GO:0045944,GO:0045944,GO:0045944,GO:0045994,GO:0046325,GO:0046330,GO:0046427,GO:0048143,GO:0048566,GO:0048661,GO:0050729,GO:0050766,GO:0050768,GO:0050796,GO:0050806,GO:0050807,GO:0050830,GO:0050890,GO:0050901,GO:0050966,GO:0050995,GO:0051044,GO:0051091,GO:0051092,GO:0051092,GO:0051092,GO:0051092,GO:0051173,GO:0051222,GO:0051384,GO:0051798,GO:0051897,GO:0051966,GO:0055037,GO:0060252,GO:0060252,GO:0060557,GO:0060559,GO:0060664,GO:0060693,GO:0061044,GO:0061048,GO:0070374,GO:0070886,GO:0071222,GO:0071230,GO:0071300,GO:0071316,GO:0071346,GO:0071677,GO:0071803,GO:0072577,GO:0072659,GO:0090324,GO:0090594,GO:0097191,GO:0097237,GO:0097421,GO:0097527,GO:0120190,GO:0140374,GO:0140460,GO:0150078,GO:0150129,GO:1900017,GO:1900017,GO:1900222,GO:1901224,GO:1901647,GO:1901671,GO:1902004,GO:1902065,GO:1902565,GO:1902895,GO:1903078,GO:1903140,GO:1903347,GO:1903721,GO:1904646,GO:1904707,GO:1904996,GO:1904999,GO:1905242,GO:1990268,GO:2000010,GO:2000272,GO:2000334,GO:2000343,GO:2000347,GO:2000351,GO:2000377,GO:2000573,GO:2001234,GO:2001238,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNF hsa:7124 path:hsa01523 Antifolate resistance - Homo sapiens (human)
TNF hsa:7124 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNF hsa:7124 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
TNF hsa:7124 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04210 Apoptosis - Homo sapiens (human)
TNF hsa:7124 path:hsa04217 Necroptosis - Homo sapiens (human)
TNF hsa:7124 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
TNF hsa:7124 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
TNF hsa:7124 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
TNF hsa:7124 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
TNF hsa:7124 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
TNF hsa:7124 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
TNF hsa:7124 path:hsa04931 Insulin resistance - Homo sapiens (human)
TNF hsa:7124 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
TNF hsa:7124 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
TNF hsa:7124 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
TNF hsa:7124 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
TNF hsa:7124 path:hsa05010 Alzheimer disease - Homo sapiens (human)
TNF hsa:7124 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
TNF hsa:7124 path:hsa05020 Prion disease - Homo sapiens (human)
TNF hsa:7124 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
TNF hsa:7124 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05131 Shigellosis - Homo sapiens (human)
TNF hsa:7124 path:hsa05132 Salmonella infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05133 Pertussis - Homo sapiens (human)
TNF hsa:7124 path:hsa05134 Legionellosis - Homo sapiens (human)
TNF hsa:7124 path:hsa05135 Yersinia infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05140 Leishmaniasis - Homo sapiens (human)
TNF hsa:7124 path:hsa05142 Chagas disease - Homo sapiens (human)
TNF hsa:7124 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
TNF hsa:7124 path:hsa05144 Malaria - Homo sapiens (human)
TNF hsa:7124 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
TNF hsa:7124 path:hsa05146 Amoebiasis - Homo sapiens (human)
TNF hsa:7124 path:hsa05152 Tuberculosis - Homo sapiens (human)
TNF hsa:7124 path:hsa05160 Hepatitis C - Homo sapiens (human)
TNF hsa:7124 path:hsa05161 Hepatitis B - Homo sapiens (human)
TNF hsa:7124 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05164 Influenza A - Homo sapiens (human)
TNF hsa:7124 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
TNF hsa:7124 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
TNF hsa:7124 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
TNF hsa:7124 path:hsa05310 Asthma - Homo sapiens (human)
TNF hsa:7124 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
TNF hsa:7124 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)
TNF hsa:7124 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)
TNF hsa:7124 path:hsa05330 Allograft rejection - Homo sapiens (human)
TNF hsa:7124 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
TNF hsa:7124 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
TNF hsa:7124 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
TNF hsa:7124 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
TNF hsa:7124 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RIPK1 TNF 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23180781 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TNF FADD 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TNF TRADD 10925299 11003656 11112697 11274345 11279185 11280761 11438547 11460167 11875494 12531547 12646658 12811837 12887920 1330325 1431106 14607933 14625680 14660645 14730360 15099563 15310755 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 21920725 22955274 23010170 23170255 23180781 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26801188 26972597 28574505 28765050 8663014 8910423 9488730 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TRAF2 TNF 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19287455 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23180781 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type,physical association pull down ACSN,InnateDB
TNF TRAF1 10820262 10925299 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 20038811 20184663 20435894 21133840 21232017 21411734 21826665 22955274 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 8910423 interaction type N/A ACSN
TNF TNFRSF1A 11112697 11274345 11279185 12531547 12646658 12887920 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23180781 23430059 23510023 23567181 23769623 24092389 26192618 26201938 26801188 28765050 8663014 8910423 association,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TNF FOXP3 11112697 12646658 1431106 14607933 14625680 15099563 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26192618 26201938 8910423 interaction type N/A ACSN
KLRG1 TNF 10358138 11447289 11449354 11572860 11884419 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 16424155 16461340 17307799 17617594 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
PTPN11 TNF 10358138 11447289 11449354 11572860 12138178 1238444 12393695 12421919 12707331 15169881 15240681 15699106 15713798 16204085 17307799 19406987 19479342 19833085 20363967 20435894 21469115 22483603 22683124 22955274 26192618 27557510 9751747 interaction type N/A ACSN
TIGIT TNF 22285893 22427644 25866972 26192618 26755705 26763253 27620276 28893624 interaction type N/A ACSN
TNF IKBKG 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 2649237 28462531 7594497 8910423 9743347 interaction type N/A ACSN
TNF MAP3K7 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TNF TAB2 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TNF TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TNF LIF 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 8910423 interaction type N/A ACSN
TNF DAB2IP 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26192618 26201938 26801188 28765050 8663014 8910423 interaction type N/A ACSN
TNF NSMAF 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26192618 26201938 26801188 28765050 8663014 8910423 interaction type N/A ACSN
TNF CD74 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 8910423 interaction type N/A ACSN
TNF IRF1 10820262 10925299 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 20038811 20184663 20435894 21133840 21232017 21411734 21826665 22955274 23170255 23180781 23430059 23508573 23510023 23567181 23769623 23850759 24012417 24092389 24378531 24699077 24958845 26192618 26201938 8910423 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
ADAM17 TNF 18676862 19704010 19726682 26192618 interaction type N/A ACSN
HMOX1 TNF 11399519 11875494 15644117 16127449 17260466 17689680 22461508 23390297 26192618 6357187 8871614 interaction type N/A ACSN
PPARG TNF 10432118 17681149 23390297 26192618 interaction type N/A ACSN
CDH1 TNF 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH2 TNF 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH4 TNF 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
FCAR TNF 12731048 15081523 15099567 20814939 23414611 2451784 26192618 7590867 9625766 9952373 interaction type N/A ACSN
FCER1G TNF 12731048 15081523 15099567 20814939 23414611 2451784 26192618 7590867 9625766 9952373 interaction type N/A ACSN
IL15 TNF 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 26192618 7523571 interaction type N/A ACSN
IL6 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
IL6R TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
JAK1 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
JAK2 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
TYK2 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
TNIP3 TNF 10542212 10754326 10952726 11875494 12133805 12907458 14660645 15199157 15465827 15485931 15536066 15644117 15749903 16243976 16413922 16818229 16878026 16970925 17237376 17254973 17363905 17404308 17485448 17693255 18716620 20138012 20300203 21217011 21807870 22435554 23086447 23390297 23422957 23430059 26192618 2649237 28462531 7594497 9743347 interaction type N/A ACSN
BCL3 TNF 10754326 10952726 11875494 12907458 14660645 14668329 15079071 15465827 15536066 15644117 16878026 17145890 17404308 17485448 19171876 20138012 23390297 23430059 26192618 7594497 8383323 8580069 interaction type N/A ACSN
HDAC1 TNF 10754326 10952726 11875494 12907458 14660645 14668329 15465827 15644117 16878026 17404308 17485448 21234400 22796940 23390297 26192618 7594497 interaction type N/A ACSN
IRF4 TNF 10754326 10952726 11438547 11875494 12907458 14660645 15218058 15465827 15644117 15749903 16243976 16413922 16713974 16878026 17404308 17485448 20580461 22003200 23390297 24378531 26192618 7594497 9743347 interaction type N/A ACSN
HIF1A TNF 10754326 10804084 10952726 11875494 12907458 14660645 15465827 15644117 16110315 16127144 16878026 17404308 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 23390297 24006507 25043024 25103413 25732824 26192618 7594497 interaction type N/A ACSN
STAT1 TNF 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 26192618 6357187 7594497 8683106 8871614 interaction type N/A ACSN
TNF MIF 10754326 10878343 10925299 10952726 11112697 11438547 11875494 12646658 12782713 12803886 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15465827 15644117 15699106 16283355 16713974 16878026 17404308 17485448 17916596 18490733 18633355 19411070 20038811 20184663 20435894 20861157 21133840 21411734 21826665 22595692 22955274 23170255 23390297 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 7594497 8195715 8910423 9637476 interaction type N/A ACSN
TNF HMGB1 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 8910423 interaction type N/A ACSN
LITAF TNF 15793005 23180781 physical association electrophoretic mobility shift assay InnateDB
TNF TNF 10634209 11502070 12040173 1331108 14965271 16284179 23070005 23180781 26467481 2922050 bind,physical association,up-regulates activity cross-linking study,mass spectrometry studies of complexes,x-ray crystallography InnateDB,Signor
BGN TNF 12387878 23180781 physical association solid phase assay InnateDB
TRADD TNF 12887920 19287455 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
TNF RIPK1 12887920 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNF BIRC2 12887920 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNF TRAF2 12887920 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF1B TNF 11448951 14743216 19287455 23180781 physical association pull down,surface plasmon resonance,tandem affinity purification InnateDB
TNFRSF1A TNF 11448951 14743216 19287455 2158863 23180781 2848815 7852363 physical association anti tag coimmunoprecipitation,pull down,surface plasmon resonance,tandem affinity purification,solid phase assay InnateDB
CHUK TNF 19287455 23180781 physical association pull down InnateDB
KHSRP TNF 15175153 23180781 physical association nucleic acid uv cross-linking assay InnateDB
A2M TNF 23180781 9780213 physical association comigration in non denaturing gel electrophoresis InnateDB
IRF3 TNF 18713975 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 TNF 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFAT5 TNF 11485737 16027109 23180781 physical association anti tag coimmunoprecipitation,DNase I footprinting InnateDB
ELAVL1 TNF 16935932 23180781 physical association electrophoretic mobility supershift assay InnateDB
ETS1 TNF 16199883 23180781 physical association anti tag coimmunoprecipitation InnateDB
JUN TNF 16199883 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELA TNF 16199883 21245135 21602809 23180781 25888873 physical association anti tag coimmunoprecipitation InnateDB
LRRFIP1 TNF 16199883 23180781 24567534 physical association anti tag coimmunoprecipitation InnateDB
SIRT1 TNF 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELB TNF 21245135 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 TNF 12560487 19374776 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
NFATC2 TNF 12560487 16027109 23180781 physical association electrophoretic mobility shift assay,DNase I footprinting InnateDB
NFATC1 TNF 16027109 23180781 physical association DNase I footprinting InnateDB
NFATC4 TNF 16027109 23180781 physical association DNase I footprinting InnateDB
NFATC3 TNF 16027109 23180781 physical association DNase I footprinting InnateDB
CREM TNF 23180781 9545284 physical association electrophoretic mobility supershift assay InnateDB
EGR4 TNF 12560487 23180781 physical association electrophoretic mobility shift assay InnateDB
SP1 TNF 12560487 23180781 physical association electrophoretic mobility shift assay InnateDB
TNF REL 23180781 23195252 physical association anti tag coimmunoprecipitation InnateDB
TNF NFKB2 23180781 23195252 physical association anti tag coimmunoprecipitation InnateDB
TNF RELA 23180781 23195252 24012417 physical association anti tag coimmunoprecipitation InnateDB
TNF STAT1 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
TNF EP300 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
TNF CREBBP 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
TNF CEBPB 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
TNF TBP 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
TNF POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 TNF 23180781 24567534 physical association anti tag coimmunoprecipitation InnateDB
EZH2 TNF 23180781 24567534 physical association anti tag coimmunoprecipitation InnateDB
AGO2 TNF 21562054 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBM4 TNF 21562054 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZFP36 TNF 23180781 24253039 physical association electrophoretic mobility shift assay,saturation binding InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TNF 16199883 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay,surface plasmon resonance array TFlink
YBX1 TNF 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 TNF 10688670 10913190 12759366 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP3 TNF 12759366 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
LRRFIP1 TNF 16199883 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay,surface plasmon resonance array TFlink
NFAT5 TNF 11485737 16027109 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TNF 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
KRT3 TNF 16027109 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TNF 10913190 14767560 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 TNF 10688670 10748079 10913190 20068037 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB TNF 10629048 9566900 trascriptional regulation,stimulation inferred by curator TFlink
CEBPD TNF 10629048 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TNF 17707233 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 TNF 7896795 trascriptional regulation,stimulation inferred by curator TFlink
HDAC11 TNF 21239696 trascriptional regulation,stimulation inferred by curator TFlink
HDAC3 TNF 15356147 trascriptional regulation,stimulation inferred by curator TFlink
HMGB2 TNF 18218727 trascriptional regulation,stimulation inferred by curator TFlink
HSF1 TNF 18689673 trascriptional regulation,stimulation inferred by curator TFlink
IRF5 TNF 20237317 trascriptional regulation,stimulation inferred by curator TFlink
JUN TNF 10318823 10688670 10748079 10913190 7896795 9566900 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TNF 10079106 10551799 10748079 10837498 10963848 11297551 11749970 12058956 12686724 14960579 15013838 15812247 16040075 16433741 16707469 16916598 17407192 17442180 17707233 18057724 18285351 20066113 20237317 7876168 8219230 8679226 9916895 trascriptional regulation,stimulation inferred by curator TFlink
NR4A1 TNF 19213954 trascriptional regulation,stimulation inferred by curator TFlink
RELA TNF 10079106 10551799 10748079 10837498 10963848 11297551 11749970 12058956 12686724 14960579 15013838 15812247 16040075 16433741 16707469 16916598 17407192 17442180 17707233 18057724 18285351 20066113 20237317 7876168 8219230 8679226 9916895 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 TNF 21245135 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TNF 10688670 10913190 12759366 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TNF 10748079 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
EGR4 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
ELK1 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A TNF N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 TNF N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004DA9DB TNF 22917968 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000006FDD4 TNF 21271217 23795660 25416803 26041742 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00004DA9DB TNF 22917968 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000101787 TNF 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00001EB9FC TNF 23071313 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000315338 TNF 24885472 25416803 26045761 26435691 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000008A99 TNF 23804075 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 TNF 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00002075FA TNF 25416803 26041742 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TRADD TNF 25361965 interaction type N/A PTMCode2
TNF TRADD 25361965 interaction type N/A PTMCode2
ADAM17 TNF 25361965 interaction type N/A PTMCode2
TNF ADAM17 25361965 interaction type N/A PTMCode2
RALBP1 TNF 25361965 interaction type N/A PTMCode2
TNF RALBP1 25361965 interaction type N/A PTMCode2
GATA5 TNF 25361965 interaction type N/A PTMCode2
TNF GATA5 25361965 interaction type N/A PTMCode2
IFNG TNF 25361965 interaction type N/A PTMCode2
TNF IFNG 25361965 interaction type N/A PTMCode2
RIPK1 TNF 25361965 interaction type N/A PTMCode2
TNF RIPK1 25361965 interaction type N/A PTMCode2
ERG TNF 25361965 interaction type N/A PTMCode2
TNF ERG 25361965 interaction type N/A PTMCode2
TNFRSF1A TNF 25361965 interaction type N/A PTMCode2
TNF TNFRSF1A 25361965 interaction type N/A PTMCode2
BIRC2 TNF 25361965 interaction type N/A PTMCode2
TNF BIRC2 25361965 interaction type N/A PTMCode2
UBE2N TNF 25361965 interaction type N/A PTMCode2
TNF UBE2N 25361965 interaction type N/A PTMCode2
PSMC3 TNF 25361965 interaction type N/A PTMCode2
TNF PSMC3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SLU7 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
CCDC70 TNF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPATA2 TNF 25348397 N/A physical interaction ComPPI
ZCCHC12 TNF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RALBP1 TNF 25348397 N/A physical interaction ComPPI
CDC42 TNF 25348397 N/A physical interaction ComPPI
HSPA13 TNF 25348397 N/A physical interaction ComPPI
TNFAIP3 TNF 23032186 24234451 25348397 30561431 association anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
LMNA TNF 25348397 N/A physical interaction ComPPI
CALM1 TNF 25348397 N/A display technology ComPPI
MRM3 TNF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNIP1 TNF 24234451 25348397 30561431 association physical interaction,virotrap ComPPI,IntAct
OPTN TNF 25348397 N/A physical interaction ComPPI
SEMA4C TNF 25348397 N/A physical interaction ComPPI
PDIK1L TNF 14525934 25348397 8597870 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KASH5 TNF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RACK1 TNF 20080539 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
LYN TNF 25348397 N/A physical interaction ComPPI
CLU TNF 25348397 N/A physical interaction ComPPI
UBC TNF 25348397 N/A physical interaction ComPPI
UBE2N TNF 25348397 N/A physical interaction ComPPI
BGN TNF 12387878 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BTRC TNF 25348397 N/A physical interaction ComPPI
IFNG TNF 14525934 25348397 3139842 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CAV1 TNF 25348397 N/A physical interaction ComPPI
SPARCL1 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
CASP8 TNF 25348397 N/A physical interaction ComPPI
IKBKB TNF 25348397 N/A physical interaction ComPPI
TNFRSF1A TNF 10634209 12887920 14525934 14743216 19084540 20080539 20103630 22028622 23955153 24070898 24234451 25241761 25348397 25911380 2848815 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,biochemical,in vitro,in vivo,tandem affinity purification,proximity ligation assay,surface plasmon resonance array ComPPI,HPRD,IntAct
PTPRS TNF 25348397 N/A physical interaction ComPPI
NFKBIA TNF 25348397 N/A physical interaction ComPPI
PTPRZ1 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ST13 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ZFP36 TNF 15014438 21784977 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP2K2 TNF 25348397 N/A physical interaction ComPPI
ADAM9 TNF 14525934 25348397 27898060 9920899 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
FADD TNF 25348397 N/A physical interaction ComPPI
TNF PRTN3 10339575 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNF TRAF2 12887920 14525934 21822306 23955153 24234451 25348397 25911380 30561431 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,virotrap ComPPI,HPRD,IntAct
TNF ADAM17 10799478 12135369 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNF CSF1 14525934 25348397 8336080 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNF TNFRSF1B 14525934 14743216 19084540 2158863 24070898 24234451 25348397 7664431 physical association affinity chromatography technology,cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,biochemical,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
TNF TRADD 12887920 21822306 23955153 24234451 25348397 30561431 association anti tag coimmunoprecipitation,pull down,physical interaction,virotrap ComPPI,IntAct
TNF DCN 12387878 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TNF POU2F1 25348397 N/A physical interaction ComPPI
TNF FAS 25348397 N/A physical interaction ComPPI
TNF RIPK1 12887920 22028622 23104095 23815148 23955153 24234451 25348397 25911380 association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
TNF TBK1 25348397 N/A physical interaction ComPPI
TNF FBXW11 25348397 N/A physical interaction ComPPI
TNF BIRC2 12887920 21822306 23815148 24234451 25348397 25911380 30561431 association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,virotrap ComPPI,IntAct
TNF CHUK 25348397 N/A physical interaction ComPPI
TNF IKBKG 23032186 23104095 24234451 25348397 30561431 association,physical association anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
TNF TAB1 25348397 N/A physical interaction ComPPI
TNF TAB2 25348397 N/A physical interaction ComPPI
TNF RNF31 23032186 23955153 24234451 25348397 30561431 association anti tag coimmunoprecipitation,pull down,physical interaction,virotrap ComPPI,IntAct
TNF RBCK1 23032186 23104095 23955153 24234451 25348397 25911380 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TNF MAP3K7 25348397 N/A physical interaction ComPPI
TNF HSPB1 25348397 N/A physical interaction ComPPI
TNF HSPB2 25348397 N/A physical interaction ComPPI
TNF AGO2 25348397 N/A physical interaction ComPPI
TNF SHARPIN 23032186 23104095 23955153 24234451 25348397 30561431 association anti tag coimmunoprecipitation,pull down,physical interaction,virotrap ComPPI,IntAct
TNF HNRNPD 25348397 N/A physical interaction ComPPI
TNF ELAVL1 25348397 N/A physical interaction ComPPI
TNF FYN 25348397 N/A physical interaction ComPPI
TNF RNF8 25348397 N/A physical interaction ComPPI
TNF RAB5A 25348397 N/A physical interaction ComPPI
TNF LAMP2 25348397 N/A physical interaction ComPPI
TNF RC3H1 25348397 N/A physical interaction ComPPI
TNF ICOS 25348397 N/A physical interaction ComPPI
TNF HSPA12A 25348397 N/A physical interaction ComPPI
TNF INTS5 25348397 N/A physical interaction ComPPI
TNF CPD 25348397 N/A physical interaction ComPPI
TNF RHEB 25348397 N/A physical interaction ComPPI
TNF ABCB6 25348397 N/A physical interaction ComPPI
TNF NCR3LG1 25348397 N/A physical interaction ComPPI
TNF GK 25348397 N/A physical interaction ComPPI
TNF NCLN 25348397 N/A physical interaction ComPPI
TNF GLS 25348397 N/A physical interaction ComPPI
TNF FREM2 25348397 N/A physical interaction ComPPI
TNF DAG1 25348397 N/A physical interaction ComPPI
TNF PLXNA2 25348397 N/A physical interaction ComPPI
TNF LNPEP 25348397 N/A physical interaction ComPPI
TNF UFL1 25348397 N/A physical interaction ComPPI
TNF TMEM259 25348397 N/A physical interaction ComPPI
TNF PCDH7 25348397 N/A physical interaction ComPPI
TNF HS6ST2 25348397 N/A physical interaction ComPPI
TNF FLT4 25348397 N/A physical interaction ComPPI
TNF ITIH2 25348397 N/A physical interaction ComPPI
TNF NEK7 25348397 N/A physical interaction ComPPI
TNF BDH1 25348397 N/A physical interaction ComPPI
TNF NRP1 25348397 N/A physical interaction ComPPI
TNF CDYL 25348397 N/A physical interaction ComPPI
TNF GUF1 25348397 N/A physical interaction ComPPI
TNF B4GALT1 25348397 N/A physical interaction ComPPI
TNF MTX3 25348397 N/A physical interaction ComPPI
TNF CELSR2 25348397 N/A physical interaction ComPPI
TNF TNFSF9 25348397 N/A physical interaction ComPPI
TNF TAMM41 25348397 N/A physical interaction ComPPI
TNF SFXN5 25348397 N/A physical interaction ComPPI
TNF ACP2 25348397 N/A physical interaction ComPPI
TNF TM2D3 25348397 N/A physical interaction ComPPI
TNF RAB18 25348397 N/A physical interaction ComPPI
TNF B4GALT5 25348397 N/A physical interaction ComPPI
TNF NEO1 25348397 N/A physical interaction ComPPI
TNF CYLD 25348397 N/A physical interaction ComPPI
TNF SEC61A1 25348397 N/A physical interaction ComPPI
TNF CD276 25348397 N/A physical interaction ComPPI
TNF LTBR 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
TNF LTA 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
TNF EED 20080539 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TNF SMPD3 20080539 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TNF RPS18 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF SPOCK1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF NT5DC3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF LIN54 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF ATP2A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF SEC16A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF CARS1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TNF BIRC3 21822306 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TNF FOXP3 24234451 25348397 25712342 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TNF BCL2L13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF VSIR 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF PLEKHO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF STX1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF CCDC107 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF PANX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF LRRC25 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF CLDN7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF RNF19B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF FNDC9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF FFAR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF SLC14A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF SLC30A4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF SSMEM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF CYB5R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF SGCB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF PIP4P2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF STOM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF AQP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNF CLEC10A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
YWHAQ TNF 25348397 N/A physical interaction ComPPI
CAPNS1 TNF 25348397 N/A physical interaction ComPPI
DDX19B TNF 25348397 N/A physical interaction ComPPI
OTULIN TNF 25348397 N/A physical interaction ComPPI
SCG2 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NEFL TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ERICH2 TNF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MMP17 TNF 10799478 14525934 N/A experimental interaction detection HPRD
TNF TNF 14525934 19838188 23815148 24234451 2551905 2922050 3351931 3417634 8869635 9442056 9488135 N/A experimental interaction detection,molecular sieving,x-ray crystallography,blue native page HPRD,IntAct
CALM2 TNF 20195357 24234451 physical association display technology IntAct
TNF RELA 19103749 20237317 24234451 association chromatin immunoprecipitation assay IntAct
BRD4 TNF 19103749 24234451 association chromatin immunoprecipitation assay IntAct
EP300 TNF 19103749 24234451 association chromatin immunoprecipitation assay IntAct
SNAI1 TNF 24234451 25314079 association chromatin immunoprecipitation assay IntAct
POLR2A TNF 20237317 24234451 association chromatin immunoprecipitation assay IntAct
TNF IRF5 20237317 24234451 association chromatin immunoprecipitation assay IntAct
TNIP2 TNF 24234451 30561431 association virotrap IntAct
TNF CHUK 19287455 27898060 stimulant N/A OmniPath
TNF TRAF2 12887920 15485837 16603398 19287455 20005846 24980434 25911380 27898060 N/A N/A OmniPath
SIRT6 TNF 23552949 27898060 stimulant N/A OmniPath
ELAVL1 TNF 16935932 27898060 N/A N/A OmniPath
TNF BCL2 10669763 15225643 27898060 N/A N/A OmniPath
TNF TNFRSF1B 11448951 12040173 1310388 1328224 14743216 15450251 15485837 19084540 19287455 2158863 2172983 24070898 27898060 7664431 7852363 7930591 7966397 8182064 8590321 8805640 9568681 stimulant N/A OmniPath
TNF AKT1 11287630 27898060 stimulant N/A OmniPath
TNF IRS1 11287630 27898060 inhibition,stimulant N/A OmniPath
AGO2 TNF 21562054 27898060 N/A N/A OmniPath
MAPK3 TNF 27898060 8597870 N/A N/A OmniPath
TNF PIK3CA 10485710 27898060 stimulant N/A OmniPath
ADAM17 TNF 10799478 12135369 27898060 9034190 stimulant N/A OmniPath
TNF TRADD 12753742 12887920 15485837 16603398 19287455 20005846 22099304 23732909 24980434 27898060 inhibition N/A OmniPath
TNF HMOX1 18202225 27898060 N/A N/A OmniPath
TNF PSIP1 16403949 27898060 stimulant N/A OmniPath
TNF NFE2L2 18202225 27898060 stimulant N/A OmniPath
TNF BIRC2 12887920 20005846 25911380 27898060 N/A N/A OmniPath
TNF RIPK1 12753742 12887920 16603398 18621737 19955178 20005846 21331077 21620750 22099304 22675546 23032187 24469399 24726327 24980434 25911380 26670046 27898060 N/A N/A OmniPath
TNF TNFRSF1A 10634209 11448951 11502070 12753742 12887920 1310388 1331108 14743216 14965271 15485837 18621737 19084540 19287455 19442713 20080539 20103630 2158863 2170559 2170974 22099304 22675546 22801493 23032187 23070005 23746843 23955153 24070898 24469399 24726327 24980434 25241761 25911380 26186194 26670046 27898060 2848815 7852363 8182064 8288897 8805640 9568681 stimulant N/A OmniPath
TNF AKT2 11287630 27898060 stimulant N/A OmniPath
KHSRP TNF 15175153 27898060 N/A N/A OmniPath
TNF PIK3CB 10485710 27898060 stimulant N/A OmniPath
A2M TNF 27898060 9780213 N/A N/A OmniPath
TNF PIK3CG 10485710 27898060 stimulant N/A OmniPath
TNF BGN 12387878 27898060 N/A N/A OmniPath
TNF TNFRSF21 27898060 9714541 stimulant N/A OmniPath
PDIK1L TNF 27898060 8597870 N/A N/A OmniPath

Visualization










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