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GENE：RBL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RBL2
FullNmae RB transcriptional corepressor like 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9894
EnsembleID ENSG00000103479
Uniprot Q08999

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RBL2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBL2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBL2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RBL2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RBL2 GO:0000785,GO:0000977,GO:0005515,GO:0005654,GO:0005654,GO:0005667,GO:0005694,GO:0005730,GO:0005829,GO:0006325,GO:0006357,GO:0007049,GO:0010629,GO:0030154,GO:0043550,GO:0070062,GO:1990841,GO:2000134

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RBL2 hsa:5934 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
RBL2 hsa:5934 path:hsa04110 Cell cycle - Homo sapiens (human)
RBL2 hsa:5934 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
RBL2 hsa:5934 path:hsa04218 Cellular senescence - Homo sapiens (human)
RBL2 hsa:5934 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
RBL2 hsa:5934 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RBL2 PHB 10523633 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBL2 BECN1 11564866 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBL2 SNX19 11564866 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBL2 SUZ12 11564866 23180781 physical association anti tag coimmunoprecipitation InnateDB
RBL2 PA2G4 21085677 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF3 RBL2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 RBL2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 RBL2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 RBL2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 RBL2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RBL2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RBL2 18971253 21325284 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RBL2 18971253 22431919 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 RBL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NAB2 RBL2 22431919 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 RBL2 19051271 trascriptional regulation,stimulation inferred by curator TFlink
TWIST2 RBL2 19051271 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 RBL2 21283765 23377830 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00002075FA RBL2 21283765 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000042E1F RBL2 21283765 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 RBL2 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA RBL2 21283765 23250421 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000042E1F RBL2 21283765 23622248 25416803 mrna cleavage,inhibition clash,miRNA interference luciferase reporter assay TarBase
URS00000600E6 RBL2 17242205 21283765 23377830 24166509 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 RBL2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002FC5B0 RBL2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 RBL2 24045973 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001A7F58 RBL2 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 RBL2 22135298 phosphorylation N/A PhosphoSite
CDK4 RBL2 22135298 phosphorylation N/A PhosphoSite
CDK6 RBL2 22135298 phosphorylation N/A PhosphoSite
NEK6 RBL2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SNW1 RBL2 12466551 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CDKN1A RBL2 25348397 N/A physical interaction ComPPI
GSTM3 RBL2 17531812 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CCND1 RBL2 14525934 16600870 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDK6 RBL2 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
LIN37 RBL2 17531812 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCBD1 RBL2 25348397 N/A physical interaction ComPPI
SKP1 RBL2 25348397 N/A physical interaction ComPPI
RINT1 RBL2 14525934 16600870 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
EZH2 RBL2 15077161 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MYOD1 RBL2 25348397 27898060 9121766 N/A physical interaction,biochemical ComPPI,OmniPath
TAF1 RBL2 14525934 25348397 9242374 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBTF RBL2 11042686 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DGKZ RBL2 14525934 16286473 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD
SERPINB2 RBL2 25348397 N/A physical interaction ComPPI
IRF3 RBL2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PHB RBL2 10376528 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RBL2 SUV39H1 12588981 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RBL2 E2F4 11573202 14525934 17159899 17531812 20133863 22002537 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RBL2 E2F5 11756542 14525934 17531812 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RBL2 RBBP9 14525934 25348397 9697699 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RBL2 RBBP8 10449734 24234451 25348397 physical association two hybrid,coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
RBL2 BRF2 10330166 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RBL2 CREG1 14525934 25348397 9710587 N/A experimental interaction detection,in vitro ComPPI,HPRD
RBL2 HBP1 14525934 25348397 9178770 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RBL2 CCNA1 10022926 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RBL2 CDK2 14525934 17531812 23455922 23602568 24234451 25348397 25852190 9188854 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
RBL2 BRF1 10330166 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RBL2 ID2 11034201 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RBL2 MNDA 14525934 16458891 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RBL2 CCNA2 14525934 17531812 24234451 25348397 8253383 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RBL2 CCNE1 14525934 25348397 8253383 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RBL2 CCND3 14525934 16600870 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RBL2 KMT5C 14525934 15750587 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RBL2 MCM7 14525934 25348397 9566894 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RBL2 RAF1 14525934 25348397 9819434 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RBL2 BRCA1 25348397 N/A physical interaction ComPPI
RBL2 HDAC1 10969803 14525934 25348397 9724731 N/A coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD
RBL2 USP4 25348397 N/A physical interaction ComPPI
RBL2 XBP1 25348397 N/A physical interaction ComPPI
RBL2 PPP2CA 15467457 24234451 25348397 dephosphorylation reaction,physical association coimmunoprecipitation,physical interaction,phosphatase assay ComPPI,IntAct
RBL2 SKP2 12435635 12717421 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RBL2 CUL1 25348397 N/A physical interaction ComPPI
RBL2 LIN54 17531812 19725879 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 LIN9 17531812 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 LIN52 17531812 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 RBL1 15467457 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 TFDP1 17531812 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 TFDP2 17531812 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 RBBP4 17531812 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 ELAVL1 25348397 N/A physical interaction ComPPI
RBL2 SMARCA4 25348397 N/A physical interaction ComPPI
RBL2 TOP1 25348397 N/A physical interaction ComPPI
RBL2 GRAMD4 25348397 N/A physical interaction ComPPI
RBL2 LBX1 25348397 N/A physical interaction ComPPI
RBL2 DCTN1 25348397 N/A physical interaction ComPPI
RBL2 LDHC 25348397 N/A physical interaction ComPPI
RBL2 RAD50 25348397 N/A physical interaction ComPPI
RBL2 E2F1 25348397 N/A physical interaction ComPPI
RBL2 CDK4 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
RBL2 DYRK1B 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RBL2 DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RBL2 PML 22002537 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RBL2 CCND2 25348397 N/A physical interaction ComPPI
RBL2 TXNDC11 25348397 N/A physical interaction ComPPI
RBL2 AP5Z1 25348397 N/A physical interaction ComPPI
RBL2 FOXK1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RBL2 RARG 25348397 N/A physical interaction ComPPI
RBL2 CCNE2 17531812 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
RBL2 ISCU 17531812 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RBL2 TMLHE 17531812 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
AATF RBL2 25348397 N/A physical interaction ComPPI
RBL2 E2F5 11756542 15838517 16600870 17531812 27898060 7760804 stimulant N/A OmniPath
CDK6 RBL2 11042701 11157749 12006580 12023960 22094256 27898060 inhibition N/A OmniPath
CDK2 RBL2 11042701 11157749 12006580 20857408 23455922 23602568 25852190 26186194 27898060 9188854 9472014 9891079 inhibition N/A OmniPath
IRF3 RBL2 21903422 27898060 N/A N/A OmniPath
RBL2 E2F4 11573202 12006580 15838517 16600870 17159899 17531812 17671431 22002537 23108140 27898060 8657117 9144196 9858615 stimulant N/A OmniPath
CDK4 RBL2 11157749 12006580 12435635 21498570 22094256 27898060 inhibition N/A OmniPath
MAPK1 RBL2 11157749 27898060 N/A N/A OmniPath
PPP2CA RBL2 15467457 27898060 stimulant N/A OmniPath
CCND1 RBL2 12006580 16600870 27898060 inhibition N/A OmniPath

Visualization










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