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GENE：INSR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol INSR
FullNmae insulin receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6091
EnsembleID ENSG00000171105
Uniprot P06213

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
INSR mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
INSR autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
INSR GO:0001540,GO:0001934,GO:0002092,GO:0003007,GO:0004713,GO:0004713,GO:0005009,GO:0005009,GO:0005009,GO:0005159,GO:0005515,GO:0005524,GO:0005525,GO:0005635,GO:0005764,GO:0005770,GO:0005886,GO:0005886,GO:0005886,GO:0005899,GO:0005899,GO:0005899,GO:0005901,GO:0005975,GO:0006355,GO:0006468,GO:0006898,GO:0007169,GO:0007186,GO:0007275,GO:0007612,GO:0007613,GO:0008284,GO:0008284,GO:0008284,GO:0008286,GO:0008286,GO:0008286,GO:0008544,GO:0008584,GO:0009897,GO:0010008,GO:0016020,GO:0018108,GO:0019904,GO:0030238,GO:0030325,GO:0030335,GO:0030424,GO:0031017,GO:0031623,GO:0031981,GO:0031994,GO:0031995,GO:0032147,GO:0032148,GO:0032590,GO:0032809,GO:0032869,GO:0033674,GO:0038024,GO:0042593,GO:0042593,GO:0043235,GO:0043243,GO:0043406,GO:0043410,GO:0043410,GO:0043410,GO:0043548,GO:0043559,GO:0043559,GO:0043560,GO:0043560,GO:0044877,GO:0045429,GO:0045725,GO:0045821,GO:0045840,GO:0045893,GO:0045995,GO:0046326,GO:0046326,GO:0046718,GO:0046777,GO:0046777,GO:0048639,GO:0051425,GO:0051446,GO:0051897,GO:0051897,GO:0060267,GO:0070062,GO:0071363,GO:0097062,GO:0097242,GO:0150104,GO:1990535,GO:2000194

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
INSR hsa:3643 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
INSR hsa:3643 path:hsa04520 Adherens junction - Homo sapiens (human)
INSR hsa:3643 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
INSR hsa:3643 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
INSR hsa:3643 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
INSR hsa:3643 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
INSR hsa:3643 path:hsa04931 Insulin resistance - Homo sapiens (human)
INSR hsa:3643 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
INSR hsa:3643 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
INSR hsa:3643 path:hsa05010 Alzheimer disease - Homo sapiens (human)
INSR hsa:3643 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
INSR STAT5B 23180781 9428692 physical association two hybrid InnateDB
INSR INSR 10909964 12220227 12456798 23180781 26467481 interaction type,phosphorylation reaction,up-regulates activity protein kinase assay InnateDB,Signor
INSR STAT3 16382134 23180781 physical association anti tag coimmunoprecipitation InnateDB
INSR RACK1 16382134 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,gst pull down InnateDB
INSR PTPN1 11579209 12237455 12612081 14722096 17481567 23180781 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,peptide array,solid phase assay InnateDB
GRB10 INSR 12493740 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK1 INSR 11409918 23180781 physical association anti tag coimmunoprecipitation InnateDB
INSR MAPK1 11409918 23180781 physical association anti tag coimmunoprecipitation InnateDB
INSR MAPK3 11409918 23180781 physical association anti tag coimmunoprecipitation InnateDB
SOCS7 INSR 16127460 23180781 physical association anti tag coimmunoprecipitation InnateDB
INSR IRS1 11606564 12101187 15629149 16582879 18988627 23331499 7935368 8662806 stimulation N/A SignaLink,SignaLink
INSR IRS2 12101187 18988627 23331499 8626379 8662806 9195949 stimulation N/A SignaLink,SignaLink
INS INSR 16956584 18988627 23331499 2550426 stimulation N/A SignaLink,SignaLink
IGF2 INSR 23331499 9281335 stimulation N/A SignaLink,SignaLink
PTPN1 INSR 11506178 12237455 15632081 16582879 23331499 8826975 9355745 stimulation N/A SignaLink
PTPN2 INSR 15632081 23331499 stimulation N/A SignaLink
INSR GRB7 10803466 23331499 stimulation N/A SignaLink
INSR DOK4 12730241 23331499 stimulation N/A SignaLink
INSR DOK5 12730241 23331499 stimulation N/A SignaLink
PTPRF INSR 11158333 1321126 15588985 19910497 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CAV1 INSR 20005715 interaction type N/A PSP
CAV3 INSR 20005715 interaction type N/A PSP
CRK INSR 15522217 18988627 20005715 interaction type N/A PSP,SignaLink
DOK1 INSR 20005715 interaction type N/A PSP,SignaLink
DOK4 INSR 20005715 interaction type N/A PSP,SignaLink
DOK5 INSR 12730241 18988627 20005715 interaction type N/A PSP,SignaLink
FRS2 INSR 20005715 interaction type N/A PSP
GAB1 INSR 20005715 interaction type N/A PSP,SignaLink
GRB10 INSR 12493740 18988627 20005715 21071413 7479769 8621530 9506989 interaction type N/A PSP,SignaLink
GRB14 INSR 20005715 interaction type N/A PSP
GRB2 INSR 20005715 interaction type N/A PSP
GRB7 INSR 20005715 interaction type N/A PSP
IRS1 INSR 20005715 interaction type N/A PSP
IRS2 INSR 20005715 interaction type N/A PSP
PIK3R1 INSR 20005715 interaction type N/A PSP,SignaLink
SH2B1 INSR 20005715 interaction type N/A PSP
SH2B2 INSR 20005715 interaction type N/A PSP
SHC1 INSR 20005715 interaction type N/A PSP
SNX6 INSR 20005715 interaction type N/A PSP
SOCS1 INSR 20005715 interaction type N/A PSP
SOCS2 INSR 20005715 interaction type N/A PSP
SOCS3 INSR 20005715 interaction type N/A PSP
SOCS6 INSR 20005715 interaction type N/A PSP
SORBS1 INSR 20005715 interaction type N/A PSP
YWHAB INSR 20005715 interaction type N/A PSP
CAV1 INSR 10598578 18988627 20005715 21071413 N/A N/A SignaLink
SOCS2 INSR 20005715 N/A N/A SignaLink
GRB2 INSR 20005715 21071413 9083103 N/A N/A SignaLink
GRB14 INSR 11726652 16582879 18988627 20005715 20005715 21071413 N/A N/A SignaLink
FRS2 INSR 10650943 10650943 18988627 20005715 20005715 21071413 N/A N/A SignaLink
GRB7 INSR 10803466 10803466 18988627 20005715 20005715 21071413 N/A N/A SignaLink
SH2B1 INSR 10594240 10594240 18988627 20005715 20005715 21071413 9742218 9742218 9742218 N/A N/A SignaLink
SH2B2 INSR 10196204 18988627 20005715 20005715 N/A N/A SignaLink
SOCS1 INSR 15169905 18988627 20005715 20005715 N/A N/A SignaLink
SOCS3 INSR 11071852 12560330 12560330 18988627 20005715 20005715 21071413 N/A N/A SignaLink
YWHAB INSR 15629149 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 INSR 11606564 20005715 20005715 21071413 8626379 N/A N/A SignaLink
IRS2 INSR 20005715 20005715 21071413 8626379 N/A N/A SignaLink
SHC1 INSR 10803466 20005715 20005715 21071413 N/A N/A SignaLink
CAV3 INSR 20005715 20005715 N/A N/A SignaLink
SNX6 INSR 11279102 18988627 20005715 20005715 N/A N/A SignaLink
SOCS6 INSR 20005715 20005715 N/A N/A SignaLink
SORBS1 INSR 11374898 11374898 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR INSR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 INSR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC INSR 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 INSR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 INSR 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA INSR 18971253 8288055 trascriptional regulation,stimulation inferred by curator TFlink
CTCF INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 INSR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB INSR 8288055 trascriptional regulation,stimulation inferred by curator TFlink
ESR2 INSR 22099628 trascriptional regulation,stimulation inferred by curator TFlink
HMGA1 INSR 16707431 17434141 trascriptional regulation,stimulation inferred by curator TFlink
SP1 INSR 1311316 16707431 7983788 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 INSR 1311316 16707431 7983788 trascriptional regulation,stimulation inferred by curator TFlink
NFIC INSR N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 INSR 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000040EE1D INSR 25240198 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000041CB9C INSR 25416803 26179126 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
INSR IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
INSR BLVRA 22135298 phosphorylation N/A PhosphoSite
INSR PIK3R1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
INSR GAB1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
INSR ARHGAP5 22135298 phosphorylation N/A PhosphoSite
INSR DOK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
INSR PTEN 22135298 phosphorylation N/A PhosphoSite
INSR PIK3R3 22135298 phosphorylation N/A PhosphoSite
INSR INSR 22135298 phosphorylation N/A PhosphoSite
INSR PTPN6 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
INSR PHB 22135298 phosphorylation N/A PhosphoSite
INSR NFKBIA 22135298 phosphorylation N/A PhosphoSite
INSR PPP2CA 22135298 phosphorylation N/A PhosphoSite
PRKCA INSR 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
FABP4 INSR 25361965 interaction type N/A PTMCode2
INSR FABP4 25361965 interaction type N/A PTMCode2
GRB14 INSR 25361965 interaction type N/A PTMCode2
INSR GRB14 25361965 interaction type N/A PTMCode2
MAPK1 INSR 25361965 interaction type N/A PTMCode2
INSR MAPK1 25361965 interaction type N/A PTMCode2
YWHAE INSR 25361965 interaction type N/A PTMCode2
INSR YWHAE 25361965 interaction type N/A PTMCode2
CBL INSR 25361965 interaction type N/A PTMCode2
INSR CBL 25361965 interaction type N/A PTMCode2
DOK5 INSR 25361965 interaction type N/A PTMCode2
INSR DOK5 25361965 interaction type N/A PTMCode2
SHC2 INSR 25361965 interaction type N/A PTMCode2
INSR SHC2 25361965 interaction type N/A PTMCode2
GAB1 INSR 25361965 interaction type N/A PTMCode2
INPPL1 INSR 25361965 interaction type N/A PTMCode2
INSR INPPL1 25361965 interaction type N/A PTMCode2
PTPN12 INSR 25361965 interaction type N/A PTMCode2
INSR PTPN12 25361965 interaction type N/A PTMCode2
ACP1 INSR 25361965 interaction type N/A PTMCode2
INSR ACP1 25361965 interaction type N/A PTMCode2
INSR PRKCA 25361965 interaction type N/A PTMCode2
CRK INSR 25361965 interaction type N/A PTMCode2
INSR CRK 25361965 interaction type N/A PTMCode2
PIK3R1 INSR 25361965 interaction type N/A PTMCode2
DOK1 INSR 25361965 interaction type N/A PTMCode2
IRS1 INSR 25361965 interaction type N/A PTMCode2
INSR ADRB2 25361965 interaction type N/A PTMCode2
ADRB2 INSR 25361965 interaction type N/A PTMCode2
INSR SOCS6 25361965 interaction type N/A PTMCode2
SOCS6 INSR 25361965 interaction type N/A PTMCode2
INSR HRAS 25361965 interaction type N/A PTMCode2
HRAS INSR 25361965 interaction type N/A PTMCode2
INSR PTPN2 25361965 interaction type N/A PTMCode2
PTPN2 INSR 25361965 interaction type N/A PTMCode2
INSR KHDRBS1 25361965 interaction type N/A PTMCode2
KHDRBS1 INSR 25361965 interaction type N/A PTMCode2
INSR SOCS3 25361965 interaction type N/A PTMCode2
SOCS3 INSR 25361965 interaction type N/A PTMCode2
INSR PRKCD 25361965 interaction type N/A PTMCode2
PRKCD INSR 25361965 interaction type N/A PTMCode2
INSR PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 INSR 25361965 interaction type N/A PTMCode2
INSR SH2B1 25361965 interaction type N/A PTMCode2
SH2B1 INSR 25361965 interaction type N/A PTMCode2
INSR GRB2 25361965 interaction type N/A PTMCode2
GRB2 INSR 25361965 interaction type N/A PTMCode2
INSR CAV1 25361965 interaction type N/A PTMCode2
CAV1 INSR 25361965 interaction type N/A PTMCode2
INSR SOCS2 25361965 interaction type N/A PTMCode2
SOCS2 INSR 25361965 interaction type N/A PTMCode2
INSR STAT5A 25361965 interaction type N/A PTMCode2
STAT5A INSR 25361965 interaction type N/A PTMCode2
INSR CAV3 25361965 interaction type N/A PTMCode2
CAV3 INSR 25361965 interaction type N/A PTMCode2
INSR DOK4 25361965 interaction type N/A PTMCode2
DOK4 INSR 25361965 interaction type N/A PTMCode2
INSR PTPRC 25361965 interaction type N/A PTMCode2
PTPRC INSR 25361965 interaction type N/A PTMCode2
INSR PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 INSR 25361965 interaction type N/A PTMCode2
INSR IRS2 25361965 interaction type N/A PTMCode2
IRS2 INSR 25361965 interaction type N/A PTMCode2
INSR JAK2 25361965 interaction type N/A PTMCode2
JAK2 INSR 25361965 interaction type N/A PTMCode2
INSR GRB10 25361965 interaction type N/A PTMCode2
GRB10 INSR 25361965 interaction type N/A PTMCode2
PTPN6 INSR 25361965 interaction type N/A PTMCode2
INSR AHSG 25361965 interaction type N/A PTMCode2
AHSG INSR 25361965 interaction type N/A PTMCode2
INSR SHC1 25361965 interaction type N/A PTMCode2
SHC1 INSR 25361965 interaction type N/A PTMCode2
INSR CISH 25361965 interaction type N/A PTMCode2
CISH INSR 25361965 interaction type N/A PTMCode2
PIK3R2 INSR 25361965 interaction type N/A PTMCode2
INSR PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 INSR 11071852 12560330 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PRKAA2 INSR 25348397 N/A physical interaction ComPPI
CALM1 INSR 25348397 N/A in vitro,in vivo ComPPI
PTPN6 INSR 12468540 14525934 25348397 7512963 8114715 8692915 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KRT31 INSR 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRK INSR 14525934 15522217 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
RACK1 INSR 14525934 16382134 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TAFA4 INSR 25348397 N/A physical interaction ComPPI
GRB7 INSR 10803466 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CBL INSR 10635327 11997497 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAV1 INSR 14525934 25348397 7535775 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK1 INSR 25348397 N/A physical interaction ComPPI
HRAS INSR 14525934 25348397 3109943 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SOCS1 INSR 14525934 15169905 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PIK3R1 INSR 10500481 11796522 14525934 14729945 15629149 24234451 25348397 8276809 8385099 9593725 association,physical association two hybrid,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 INSR 14525934 24234451 25348397 7493946 8135823 9593725 association,physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCA INSR 14525934 25348397 7926007 8463287 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC INSR 14525934 15337529 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPRO INSR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GRB10 INSR 12493740 14525934 24234451 25348397 7479769 8621530 9506989 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,protein three hybrid,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CRKL INSR 14525934 15522217 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
DOK1 INSR 11551902 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SH2B2 INSR 10196204 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
INS INSR 14525934 25348397 2550426 N/A experimental interaction detection,x-ray crystallography,physical interaction,biochemical,in vivo ComPPI,HPRD
VAV3 INSR 11094073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SHC1 INSR 10482988 10764799 10816433 10896916 10921922 11075717 12237775 14525934 15629149 24234451 25348397 8702728 9083103 9121430 9446569 9593725 9710204 9741627 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCD INSR 11266508 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK3 INSR 11409918 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
KHDRBS1 INSR 10437794 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB2 INSR 25348397 N/A physical interaction ComPPI
SMAD2 INSR 14525934 25348397 9092546 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MOK INSR 25348397 N/A physical interaction ComPPI
INPPL1 INSR 25348397 N/A physical interaction ComPPI
SORBS1 INSR 11374898 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FRS2 INSR 10650943 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RHOB INSR 14722096 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
YWHAB INSR 14525934 15629149 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
IRS2 INSR 14525934 24234451 25348397 8626379 8662806 9195949 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HGS INSR 25348397 N/A physical interaction ComPPI
GAB1 INSR 10978177 14525934 25348397 9658397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
AGAP2 INSR 21720388 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
PPM1A INSR 25348397 N/A physical interaction ComPPI
PIK3R3 INSR 14525934 25348397 9524259 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PRKAA1 INSR 25348397 N/A physical interaction ComPPI
UBB INSR 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC INSR 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A INSR 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 INSR 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
NTRK1 INSR 25348397 N/A physical interaction ComPPI
PTPRF INSR 11158333 1321126 14525934 15588985 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JAK1 INSR 12456798 14525934 25348397 9492017 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN1 INSR 11163213 11506178 11579209 12237455 12634852 14525934 14722096 15588987 16582879 16926280 17092689 17159996 17481567 19029027 21806020 24234451 25348397 8702689 8826975 8999839 9355745 dephosphorylation reaction,phosphorylation reaction,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,coimmunoprecipitation,experimental interaction detection,filter binding,fluorescent resonance energy transfer,pull down,x-ray crystallography,physical interaction,genetic interference,protein kinase assay,phosphatase assay,in vitro,in vivo,bimolecular fluorescence complementation ComPPI,HPRD,IntAct
SNX1 INSR 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB14 INSR 14525934 16582879 24234451 25348397 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN2 INSR 25348397 N/A anti bait coimmunoprecipitation,in vitro,in vivo ComPPI
SNX2 INSR 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CAV1 INSR 10598578 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SNX6 INSR 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SNX17 INSR 25348397 N/A physical interaction ComPPI
SOCS2 INSR 10453981 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
STAT5A INSR 12456798 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STAT5B INSR 10830280 12456798 14525934 24234451 25348397 9122188 9428692 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PTPRB INSR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRG INSR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
HNRNPL INSR 25348397 N/A physical interaction ComPPI
PTPRR INSR 25348397 N/A physical interaction ComPPI
PTPN12 INSR 14525934 19167335 24234451 25348397 8454633 dephosphorylation reaction experimental interaction detection,phosphatase assay,in vitro ComPPI,HPRD,IntAct
CYTH2 INSR 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
SQSTM1 INSR 25348397 N/A physical interaction ComPPI
CSK INSR 10026153 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ARF6 INSR 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
ARRB2 INSR 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
CAV3 INSR 14525934 25348397 9756945 N/A experimental interaction detection,in vitro ComPPI,HPRD
ADRB2 INSR 14525934 25348397 8557631 N/A experimental interaction detection,in vivo ComPPI,HPRD
SYNCRIP INSR 11994298 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RASA1 INSR 1331107 14525934 24234451 25348397 9593725 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IRS1 INSR 11606564 14525934 15629149 16582879 24234451 25348397 7935368 8662806 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,biochemical,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
JAK2 INSR 12456798 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPRC INSR 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay,in vitro ComPPI,IntAct
RAF1 INSR 11409918 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DOK4 INSR 12730241 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SH2B1 INSR 10594240 14525934 24234451 25348397 9742218 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
INSR ARF1 14525934 25348397 9197239 N/A experimental interaction detection,in vitro ComPPI,HPRD
INSR SOCS6 11342531 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
INSR CEACAM1 10805733 11694516 14525934 25348397 7592607 7626603 N/A experimental interaction detection,in vitro ComPPI,HPRD
INSR ARHGAP26 14525934 25348397 7836419 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
INSR AHSG 14525934 25348397 7906861 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
INSR IGF2 14525934 25348397 9722981 N/A experimental interaction detection,in vivo ComPPI,HPRD
INSR INSRR 14525934 25348397 8916919 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
INSR ENPP1 10615944 11289049 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
INSR FABP4 14525934 1648089 25348397 8463311 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
INSR MAD2L1 14525934 24234451 25348397 9092546 physical association two hybrid,experimental interaction detection,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
INSR DOK5 12730241 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
INSR DCN 24234451 24389353 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
INSR SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
INSR PLCG1 11796522 14525934 14568990 24234451 25348397 9593725 colocalization,physical association coimmunoprecipitation,cross-linking study,experimental interaction detection,pull down,physical interaction,fluorescence microscopy ComPPI,HPRD,IntAct
INSR IRF7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
INSR TEAD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
INSR SNX27 25348397 N/A physical interaction ComPPI
INSR ATIC 25348397 N/A physical interaction ComPPI
INSR HACD3 25348397 N/A physical interaction ComPPI
INSR KIF5A 25348397 N/A physical interaction ComPPI
INSR PTPRK 19167335 24234451 25348397 dephosphorylation reaction physical interaction,phosphatase assay ComPPI,IntAct
INSR PON2 25348397 N/A physical interaction ComPPI
INSR TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
INSR PPM1F 25348397 N/A physical interaction ComPPI
INSR DUSP18 25348397 N/A physical interaction ComPPI
INSR MPZL2 25348397 N/A physical interaction ComPPI
INSR SSH1 25348397 N/A physical interaction ComPPI
INSR UNC5CL 25348397 N/A physical interaction ComPPI
INSR SCGB1D1 25348397 N/A physical interaction ComPPI
INSR CLEC3A 25348397 N/A physical interaction ComPPI
INSR TAFA3 25348397 N/A physical interaction ComPPI
INSR INSL5 25348397 N/A physical interaction ComPPI
INSR DNASE1L2 25348397 N/A physical interaction ComPPI
INSR DUSP19 25348397 N/A physical interaction ComPPI
INSR STYX 25348397 N/A physical interaction ComPPI
INSR TRIM25 25348397 N/A physical interaction ComPPI
INSR ACP1 1304913 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
INSR CYTH3 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
INSR PTPN3 25348397 N/A dephosphorylation reaction,phosphatase assay ComPPI
INSR PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
INSR IGF1 24234451 25348397 8452530 physical association competition binding ComPPI,IntAct
IGF1R INSR 14525934 25348397 7895674 N/A experimental interaction detection,in vitro ComPPI,HPRD
INSR CALM2 12153558 14525934 8639568 N/A experimental interaction detection HPRD
INSR INSR 11401470 14525934 7806540 8496180 8504096 N/A experimental interaction detection HPRD
KRT27 INSR 14525934 15629149 N/A experimental interaction detection HPRD
KL INSR 17684529 27898060 inhibition,stimulant N/A OmniPath
PTPN13 INSR 15611135 27898060 inhibition N/A OmniPath
PRKAA2 INSR 22207502 27898060 stimulant N/A OmniPath
PRKCA INSR 10819237 12472845 1321605 2110001 27898060 7926007 8393870 8463287 9506989 stimulant N/A OmniPath
INSR PTPN1 11106648 11163213 11506178 11579209 12237455 12612081 12634852 14722096 15588987 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 27898060 8491187 8702689 8826975 8999839 9355745 inhibition N/A OmniPath
PTPN1 INSR 11163213 11506178 11579209 12237455 12612081 12634852 14722096 15588987 15632081 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 27898060 8702689 8826975 8999839 9355745 inhibition,stimulant N/A OmniPath
PTPRF INSR 10734133 11158333 1303753 1321126 15588985 19910497 27898060 7852302 8732688 8995282 inhibition,stimulant N/A OmniPath
PTPN2 INSR 10734133 12612081 1373652 15192089 15588985 15632081 27898060 inhibition,stimulant N/A OmniPath
INS INSR 11278498 15870194 23302862 2550426 27898060 stimulant N/A OmniPath
INSR PDPK1 11481331 14585963 16314505 27898060 N/A N/A OmniPath
INSR BLVRA 15870194 17639074 27898060 N/A N/A OmniPath
INSR IRS1 11606564 11781100 12220227 1385403 15629149 15870194 16582879 17167487 18083107 19534553 2159922 27898060 7499194 7537849 7651388 7935368 8626379 8626723 8662806 stimulant N/A OmniPath
INSR PTK2 17016520 17389395 19664994 20068231 27898060 7529876 9507031 stimulant N/A OmniPath
INSR PTPN6 10734133 12468540 14551136 14699166 16497976 17675340 18377662 21900501 25535246 25876760 27898060 7512963 8114715 8692915 stimulant N/A OmniPath
PTPN6 INSR 10734133 12468540 27898060 7512963 8114715 8692915 inhibition N/A OmniPath
INSR GAB1 10734310 10978177 11323411 11779868 16497976 17016520 17389395 18669648 20068231 27898060 9658397 stimulant N/A OmniPath
MAPK3 INSR 11409918 27898060 N/A N/A OmniPath
INSR IRS2 11584304 12101187 18083107 19534553 19901323 27898060 7526222 7537849 7675087 8626379 8626723 8662806 9195949 stimulant N/A OmniPath
IGF2 INSR 27898060 9281335 9722981 stimulant N/A OmniPath
INSR SHC1 10482988 10764799 10803466 10816433 10896916 10921922 11075717 12237775 15629149 16497976 17016520 17389395 18452278 18578522 18669648 19651622 19664994 19901323 20068231 20230923 27898060 7499194 7537849 7559507 8626723 8702728 9083103 9121430 9446569 9593725 9710204 9741627 stimulant N/A OmniPath
INSR PIK3R1 10500481 11337495 11796522 14729945 15629149 16497976 17016520 17389395 20068231 27898060 7589433 7983060 8276809 8385099 9461588 9593725 N/A N/A OmniPath
SH2B2 INSR 10196204 11498022 11997497 15031295 17620296 27898060 inhibition N/A OmniPath
INSR GRB10 10871840 12493740 12783867 15664450 27898060 7479769 8621530 9006901 9506989 stimulant N/A OmniPath
GRB10 INSR 10871840 12493740 15664450 21659604 27898060 7479769 8621530 9006901 9506989 inhibition N/A OmniPath
INSR CBL 10635327 10934191 11997497 12604776 15922744 15951569 27898060 stimulant N/A OmniPath
CBL INSR 10635327 11498022 11997497 27898060 inhibition N/A OmniPath
INSR GRB7 10803466 27898060 stimulant N/A OmniPath
MAPK1 INSR 11409918 27898060 N/A N/A OmniPath
INSR STAT3 16382134 27898060 N/A N/A OmniPath
INSR STAT5B 10830280 12456798 27898060 9122188 9428692 N/A N/A OmniPath
PTPRE INSR 15738637 27898060 N/A N/A OmniPath
INSR ADRB2 27898060 8557631 N/A N/A OmniPath
PTPRB INSR 10734133 19167335 27898060 inhibition N/A OmniPath
INSR DOK1 10688886 11551902 12087092 15574499 15592455 16094384 16497976 19481264 19690332 19901323 27898060 9008160 stimulant N/A OmniPath
INSR PHB 19238206 22124450 22410782 27898060 N/A N/A OmniPath
INSR PIK3R3 27898060 7542745 9524259 N/A N/A OmniPath
DUSP3 INSR 1281549 27898060 N/A N/A OmniPath
INSR FGA 1956339 27898060 6255944 N/A N/A OmniPath
PTPRH INSR 10734133 27898060 inhibition N/A OmniPath
PTPN9 INSR 16679294 27898060 inhibition N/A OmniPath
PTPN12 INSR 10734133 19167335 27898060 8454633 inhibition N/A OmniPath
ENPP1 INSR 10615944 11289049 27898060 inhibition N/A OmniPath
ACP1 INSR 1304913 17353188 27898060 9299573 N/A N/A OmniPath
INSR ARHGAP5 12705864 27898060 N/A N/A OmniPath
PTPRJ INSR 10734133 1715686 19167335 27898060 inhibition N/A OmniPath
INSR FABP4 1648089 27898060 8463311 N/A N/A OmniPath

Visualization










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