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GENE：POLD3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLD3
FullNmae DNA polymerase delta 3, accessory subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20932
EnsembleID ENSG00000077514
Uniprot Q15054

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLD3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLD3 GO:0000731,GO:0003887,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0006261,GO:0006271,GO:0006297,GO:0006297,GO:0006298,GO:0016035,GO:0016035,GO:0030674,GO:0042276,GO:0043625,GO:0043625,GO:0043625,GO:0071897,GO:1904161

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLD3 hsa:10714 path:hsa03030 DNA replication - Homo sapiens (human)
POLD3 hsa:10714 path:hsa03410 Base excision repair - Homo sapiens (human)
POLD3 hsa:10714 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLD3 hsa:10714 path:hsa03430 Mismatch repair - Homo sapiens (human)
POLD3 hsa:10714 path:hsa03440 Homologous recombination - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCNA POLD3 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 interaction type N/A ACSN
POLD1 POLD3 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 27760120 27760777 interaction type N/A ACSN
POLD4 POLD3 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 27760120 27760777 interaction type N/A ACSN
APP POLD3 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR POLD3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLD3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 POLD3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 POLD3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 POLD3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 POLD3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 POLD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE POLD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C0FCB POLD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 POLD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D POLD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000076995 POLD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BD6DC POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009EA8F POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E02F2 POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005485E8 POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A POLD3 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD POLD3 20371350 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000008F0CF POLD3 20371350 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD1DE POLD3 20371350 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000134ADC POLD3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 POLD3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC POLD3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 POLD3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D POLD3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 POLD3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A POLD3 25416803 27862371 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA POLD3 22135298 phosphorylation N/A PhosphoSite
POLD3 SUMO2 25361965 interaction type N/A PTMCode2
SUMO2 POLD3 25361965 interaction type N/A PTMCode2
POLD3 PCNA 25361965 interaction type N/A PTMCode2
PCNA POLD3 25361965 interaction type N/A PTMCode2
POLD3 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLD3 25361965 interaction type N/A PTMCode2
POLD1 POLD3 25361965 interaction type N/A PTMCode2
POLD3 POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAD2L2 POLD3 25348397 N/A physical interaction ComPPI
PCNA POLD3 10219083 11595739 12171929 14525934 15576034 16000169 16510448 16763556 24234451 25348397 26496610 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,far western blotting,fluorescent resonance energy transfer,isothermal titration calorimetry,x-ray crystallography,physical interaction,in vitro,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
POLA1 POLD3 25348397 N/A physical interaction ComPPI
POLD3 POLD1 10852724 12403614 14525934 16510448 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,molecular sieving,chromatography technology,physical interaction,ion exchange chromatography,in vivo ComPPI,HPRD,IntAct
POLD3 POLD2 16000169 16510448 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,pull down,physical interaction,in vivo ComPPI,IntAct
POLD3 MBD3L2 25348397 N/A physical interaction ComPPI
POLD3 NR2C1 25348397 N/A physical interaction ComPPI
POLD3 DNMT1 25348397 N/A physical interaction ComPPI
POLD3 MTA1 25348397 N/A physical interaction ComPPI
POLD3 HDAC1 25348397 N/A physical interaction ComPPI
POLD3 CHD4 25348397 N/A physical interaction ComPPI
POLD3 RBBP4 25348397 N/A physical interaction ComPPI
POLD3 SPRTN 25348397 N/A physical interaction ComPPI
POLD3 APP 25348397 N/A physical interaction ComPPI
POLD3 MCM3 25348397 N/A physical interaction ComPPI
POLD3 POLD4 25348397 N/A physical interaction ComPPI
POLD3 TSEN2 25348397 N/A physical interaction ComPPI
POLD3 USP8 25348397 N/A physical interaction ComPPI
POLD3 DCP2 25348397 N/A physical interaction ComPPI
POLD3 REV1 25348397 N/A physical interaction ComPPI
POLD3 SIRT6 25348397 N/A physical interaction ComPPI
POLD3 XPO1 25348397 N/A physical interaction ComPPI
POLD3 AHSA1 25348397 N/A physical interaction ComPPI
POLD3 FAF2 25348397 N/A physical interaction ComPPI
POLD3 WRNIP1 15670210 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
H3C1 POLD3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB POLD3 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKACA POLD3 22148433 27898060 inhibition N/A OmniPath
PPP1CB POLD3 18826257 27898060 N/A N/A OmniPath
PPP1CA POLD3 18826257 27898060 N/A N/A OmniPath
PPP1CC POLD3 18826257 27898060 N/A N/A OmniPath

Visualization










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