Gene Information gene info

  1. Home

GENE：PAX8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAX8
FullNmae paired box 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8622
EnsembleID ENSG00000125618
Uniprot Q06710

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAX8 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAX8 GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001655,GO:0001658,GO:0001822,GO:0001823,GO:0003281,GO:0003337,GO:0003677,GO:0003677,GO:0003700,GO:0004996,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006351,GO:0006357,GO:0006790,GO:0007417,GO:0009653,GO:0010667,GO:0030878,GO:0030878,GO:0038194,GO:0039003,GO:0042472,GO:0042981,GO:0045893,GO:0045893,GO:0045944,GO:0048793,GO:0048856,GO:0071371,GO:0071599,GO:0072108,GO:0072207,GO:0072221,GO:0072278,GO:0072284,GO:0072289,GO:0072305,GO:0072307,GO:0090190,GO:1900212,GO:1900215,GO:1900218,GO:1990837,GO:2000594,GO:2000611,GO:2000612

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAX8 hsa:7849 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
PAX8 hsa:7849 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PAX8 hsa:7849 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
PAX8 hsa:7849 path:hsa05216 Thyroid cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PAX8 HNF4A 14988562 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PAX8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 PAX8 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
MYC PAX8 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 PAX8 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PAX8 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PAX8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EZH2 PAX8 21289264 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000079D48 PAX8 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001A405B PAX8 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 PAX8 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD PAX8 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001938D9 PAX8 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 PAX8 25416803 26282166 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NKX2-1 PAX8 25361965 interaction type N/A PTMCode2
PAX8 NKX2-1 25361965 interaction type N/A PTMCode2
ETS2 PAX8 25361965 interaction type N/A PTMCode2
PAX8 ETS2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GCM2 PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CXCL9 PAX8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TMA16 PAX8 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SMAD4 PAX8 24234451 25348397 27107012 physical association split luciferase complementation ComPPI,IntAct
RB1 PAX8 21602887 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
EP300 PAX8 10924503 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
HGS PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLSTN1 PAX8 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HSPA1A PAX8 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HSPA1B PAX8 25348397 N/A display technology ComPPI
NKX2-1 PAX8 12441357 14525934 14970209 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PKM PAX8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SAE1 PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPLP2 PAX8 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
DOK4 PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHUK PAX8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POU2AF1 PAX8 25348397 N/A physical interaction ComPPI
CDK3 PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RSBN1 PAX8 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HOXC8 PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HOXC9 PAX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NCL PAX8 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PAX8 SERINC1 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
PAX8 ANXA7 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
PAX8 UNK 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PAX8 LONRF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMAD3 PAX8 14525934 14623893 N/A experimental interaction detection HPRD
WBP2 PAX8 14525934 14531730 27898060 N/A experimental interaction detection HPRD,OmniPath
PAX8 ID2 11134340 14525934 N/A experimental interaction detection HPRD
WWTR1 PAX8 19010321 27898060 stimulant N/A OmniPath
WNT1 PAX8 18495817 27898060 stimulant N/A OmniPath
FOXI1 PAX8 12702667 27898060 stimulant N/A OmniPath
TGFB1 PAX8 14623893 27898060 inhibition N/A OmniPath
NOTCH1 PAX8 18495817 27898060 stimulant N/A OmniPath
SMAD3 PAX8 14623893 27898060 inhibition N/A OmniPath

Visualization










  Return