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GENE：RASSF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RASSF1
FullNmae Ras association domain family member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9882
EnsembleID ENSG00000068028
Uniprot Q9NS23

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RASSF1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RASSF1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RASSF1 GO:0000922,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0007049,GO:0007265,GO:0007265,GO:0008270,GO:0015630,GO:0015630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RASSF1 hsa:11186 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RASSF1 hsa:11186 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
RASSF1 hsa:11186 path:hsa04392 Hippo signaling pathway - multiple species - Homo sapiens (human)
RASSF1 hsa:11186 path:hsa05200 Pathways in cancer - Homo sapiens (human)
RASSF1 hsa:11186 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
RASSF1 hsa:11186 path:hsa05219 Bladder cancer - Homo sapiens (human)
RASSF1 hsa:11186 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RASSF1 ATM 10608806 23180781 phosphorylation reaction in-gel kinase assay InnateDB
RASSF1 E2F1 20877461 23180781 physical association anti tag coimmunoprecipitation InnateDB
RASSF1 CTCF 20877461 23180781 physical association electrophoretic mobility supershift assay InnateDB
RASSF1 RASSF1 21808241 22195963 22683405 26467481 bind,up-regulates,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
RASSF1 TNFRSF10A 20005715 interaction type N/A PSP
RASSF1 MAPK8 20005715 interaction type N/A PSP
RASSF1 MAPK8 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 RASSF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A RASSF1 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
TP53 RASSF1 21364923 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
E2F4 RASSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RASSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RASSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RASSF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 RASSF1 24247422 trascriptional regulation,stimulation inferred by curator TFlink
SP1 RASSF1 19450668 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 RASSF1 19450668 trascriptional regulation,stimulation inferred by curator TFlink
SP3 RASSF1 19450668 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000508C13 RASSF1 21086164 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EC1BE RASSF1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00002C0FCB RASSF1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000021D7C8 RASSF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000048F59D RASSF1 25416803 26519551 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
ATM RASSF1 22135298 phosphorylation N/A PhosphoSite
HRAS RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 HRAS 25361965 interaction type N/A PTMCode2
DAXX RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 DAXX 25361965 interaction type N/A PTMCode2
RASSF1 ATP2B4 25361965 interaction type N/A PTMCode2
ATP2B4 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 CNKSR1 25361965 interaction type N/A PTMCode2
CNKSR1 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 STK4 25361965 interaction type N/A PTMCode2
STK4 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 XPA 25361965 interaction type N/A PTMCode2
XPA RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 RASSF2 25361965 interaction type N/A PTMCode2
RASSF2 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 STK3 25361965 interaction type N/A PTMCode2
STK3 RASSF1 25361965 interaction type N/A PTMCode2
MAP1S RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 MAP1S 25361965 interaction type N/A PTMCode2
CDC20 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 CDC20 25361965 interaction type N/A PTMCode2
MOAP1 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 MOAP1 25361965 interaction type N/A PTMCode2
E4F1 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 E4F1 25361965 interaction type N/A PTMCode2
MST1 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 MST1 25361965 interaction type N/A PTMCode2
SAV1 RASSF1 25361965 interaction type N/A PTMCode2
RASSF1 SAV1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DAXX RASSF1 16810318 18566590 21134643 21643015 23038753 24234451 25348397 27898060 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,nuclear magnetic resonance,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct,OmniPath
TUBB RASSF1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
GABARAPL2 RASSF1 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
SKP1 RASSF1 25348397 N/A physical interaction ComPPI
RASSF5 RASSF1 11857081 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP1LC3B RASSF1 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
EXOSC8 RASSF1 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MOAP1 RASSF1 14525934 15949439 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HRAS RASSF1 10998413 14525934 18596699 24234451 25348397 N/A experimental interaction detection,fluorescence technology,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TGFBR2 RASSF1 25348397 N/A physical interaction ComPPI
MAPK8 RASSF1 14525934 16810318 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ATR RASSF1 25348397 N/A physical interaction ComPPI
PRKDC RASSF1 25348397 N/A physical interaction ComPPI
USP7 RASSF1 18566590 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RHOA RASSF1 25348397 N/A physical interaction ComPPI
VAPA RASSF1 25348397 N/A physical interaction ComPPI
GSK3B RASSF1 25348397 N/A physical interaction ComPPI
TUBG1 RASSF1 14525934 14603253 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP1S RASSF1 14525934 15205320 15753381 24234451 24366813 25348397 26186194 27898060 association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
BTRC RASSF1 21900206 21910689 24234451 25348397 25900982 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
E4F1 RASSF1 25348397 N/A two hybrid,two hybrid,physical interaction,in vitro,in vivo ComPPI
XPO6 RASSF1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF1A RASSF1 14525934 15949439 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EWSR1 RASSF1 25348397 N/A two hybrid ComPPI
ATM RASSF1 25348397 N/A physical interaction ComPPI
XPO1 RASSF1 25348397 N/A physical interaction ComPPI
XPA RASSF1 10888881 14525934 24234451 25348397 27898060 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct,OmniPath
SUV39H1 RASSF1 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
HUWE1 RASSF1 25348397 N/A physical interaction ComPPI
MDM2 RASSF1 14525934 18566590 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CUL1 RASSF1 25348397 N/A physical interaction ComPPI
CUL4A RASSF1 25348397 N/A physical interaction ComPPI
VAPB RASSF1 25348397 N/A physical interaction ComPPI
SFN RASSF1 20069457 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
CDC20 RASSF1 14525934 14743218 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SKP2 RASSF1 25348397 N/A physical interaction ComPPI
GABARAP RASSF1 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
RASSF1 STK4 14525934 15109305 20562859 23386615 23455922 24234451 24255178 24366813 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
RASSF1 TNFRSF10A 14525934 15949439 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RASSF1 ATP2B4 14525934 15145946 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
RASSF1 IGFBP5 14525934 16007340 25348397 27898060 N/A two hybrid,two hybrid ComPPI,HPRD,OmniPath
RASSF1 MAP1B 14525934 15205320 24234451 24366813 25348397 association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RASSF1 CNKSR1 25348397 N/A physical interaction ComPPI
RASSF1 AURKA 25348397 N/A physical interaction ComPPI
RASSF1 AURKB 25348397 N/A physical interaction ComPPI
RASSF1 DDB1 21205828 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RASSF1 C7ORF25 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASSF1 KCNE3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASSF1 SUV39H2 21900206 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASSF1 C8ORF33 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASSF1 MAST2 25348397 N/A physical interaction ComPPI
RASSF1 SAV1 17379520 21489991 25348397 27898060 N/A two hybrid,physical interaction ComPPI,OmniPath
RASSF1 STK3 23455922 24234451 24255178 24366813 25348397 colocalization,association anti tag coimmunoprecipitation,two hybrid,physical interaction,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
RASSF1 LATS1 25348397 N/A physical interaction ComPPI
RASSF1 ID1 25348397 N/A physical interaction ComPPI
RASSF1 KDM1A 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RASSF1 FBXW11 25348397 N/A physical interaction ComPPI
RASSF1 MST1 25348397 N/A physical interaction ComPPI
RASSF1 NDUFV2 25348397 N/A physical interaction ComPPI
RASSF1 ITPRIP 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RASSF1 MTHFR 25348397 N/A physical interaction ComPPI
RASSF1 LRP6 25348397 N/A physical interaction ComPPI
RASSF1 SNX27 25348397 N/A physical interaction ComPPI
RASSF1 H2AC21 25348397 N/A physical interaction ComPPI
RASSF1 CLNK 25348397 N/A two hybrid,physical interaction ComPPI
RASSF1 LATS2 25348397 N/A physical interaction ComPPI
RASSF1 RHOU 25348397 N/A physical interaction ComPPI
RASSF1 SMURF1 25348397 N/A physical interaction ComPPI
RASSF1 TGFBR1 25348397 N/A physical interaction ComPPI
RASSF1 ITCH 25348397 N/A physical interaction ComPPI
RASSF1 ATRX 25348397 N/A physical interaction ComPPI
RASSF1 TUBB1 25348397 N/A imaging technique ComPPI
RASSF1 RASSF2 25348397 N/A two hybrid ComPPI
RASSF1 MAP1LC3C 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
RASSF1 GABARAPL1 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
RASSF1 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NUDT10 RASSF1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RASSF1 TUBB2A 14525934 14603253 N/A experimental interaction detection HPRD
RASSF1 RASSF1 11857081 14525934 N/A experimental interaction detection HPRD
CHEK1 RASSF1 24197116 27898060 N/A N/A OmniPath
AURKB RASSF1 19276349 27898060 inhibition N/A OmniPath
ATR RASSF1 25368379 27898060 N/A N/A OmniPath
ATM RASSF1 10608806 19962312 27898060 stimulant N/A OmniPath
RASSF1 STK4 15109305 17598981 20562859 21808241 22683405 23455922 24255178 24366813 26186194 26578655 27898060 stimulant N/A OmniPath
AURKA RASSF1 17563743 18071316 18514071 19276349 20655196 21468893 21874044 22389451 27898060 inhibition N/A OmniPath
RASSF1 STK3 14729613 17379520 17598981 17889669 19962312 20086174 21199877 21808241 22195963 23455922 24255178 24366813 26186194 27898060 stimulant N/A OmniPath
RASSF5 RASSF1 11857081 16713569 22195963 27898060 stimulant N/A OmniPath
CDK4 RASSF1 18071316 27898060 inhibition N/A OmniPath
RASSF1 CDC20 14743218 18372912 19276349 21874044 27898060 inhibition N/A OmniPath
GSK3B RASSF1 20069457 27898060 N/A N/A OmniPath
KRAS RASSF1 22195963 27898060 stimulant N/A OmniPath
CNKSR1 RASSF1 15075335 22830020 27898060 stimulant N/A OmniPath

Visualization










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