GENE：BIRC5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BIRC5 |
| FullNmae | baculoviral IAP repeat containing 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:593 |
| EnsembleID | ENSG00000089685 |
| Uniprot | O15392 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BIRC5 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BIRC5 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BIRC5 | GO:0000228,GO:0000278,GO:0000281,GO:0000775,GO:0000776,GO:0001934,GO:0004869,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0005829,GO:0005874,GO:0006468,GO:0006915,GO:0007052,GO:0007605,GO:0008017,GO:0008284,GO:0015630,GO:0019899,GO:0030496,GO:0031267,GO:0031503,GO:0032133,GO:0042802,GO:0043066,GO:0043066,GO:0045892,GO:0046872,GO:0051087,GO:0051256,GO:0090267,GO:1901970,GO:1902425,GO:1903490,GO:1990713 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| BIRC5 | hsa:332 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| BIRC5 | hsa:332 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BIRC5 | AURKB | 12925766 14767480 15249581 16571674 17956729 26192618 | interaction type | N/A | ACSN |
| BIRC5 | INCENP | 12925766 14767480 15249581 16571674 17956729 26192618 | interaction type | N/A | ACSN |
| BIRC5 | DIABLO | 12660240 12925766 15249581 16571674 17956729 26192618 | association | N/A | ACSN |
| BIRC5 | APC2 | 12925766 14767480 15249581 16571674 17956729 26192618 | interaction type | N/A | ACSN |
| BIRC5 | CDC20 | 12925766 14767480 15249581 16571674 17956729 26192618 | interaction type | N/A | ACSN |
| BIRC5 | BUB3 | 12925766 14767480 15249581 16571674 17956729 26192618 | interaction type | N/A | ACSN |
| BIRC5 | BUB1 | 12925766 14767480 15249581 16571674 17956729 26192618 | interaction type | N/A | ACSN |
| CDK1 | BIRC5 | 11069302 12124778 12792650 14551205 15279786 15917306 17303408 17466630 17660363 18414028 18590585 19016842 19081073 19586613 19652693 26192618 7575488 | interaction type | N/A | ACSN |
| BIRC5 | XIAP | 15218035 17613533 23180781 | physical association | anti tag coimmunoprecipitation,gst pull down | InnateDB |
| BIRC2 | BIRC5 | 15218035 23180781 | physical association | gst pull down | InnateDB |
| BIRC3 | BIRC5 | 15218035 23180781 | physical association | gst pull down | InnateDB |
| BIRC5 | HSP90AA1 | 15218035 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BIRC5 | HSPA4 | 15218035 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CASP3 | BIRC5 | 16540654 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BIRC5 | MAP3K5 | 16540654 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| DIABLO | BIRC5 | 16540654 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| LEF1 | BIRC5 | 21795403 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BIRC5 | MYB | 21795403 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KLF5 | BIRC5 | 16595680 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| E2F4 | BIRC5 | 17531812 17671431 18504435 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay | TFlink |
| ETS1 | BIRC5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SP1 | BIRC5 | 17124180 22334592 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| STAT3 | BIRC5 | 15184887 15469392 16397018 16651438 17533050 17880940 19284568 19880237 20826784 21344490 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| TP53 | BIRC5 | 17124180 17699779 19067706 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| KLF4 | BIRC5 | 19361279 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| APC | BIRC5 | 11751382 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTNNB1 | BIRC5 | 19662654 19778454 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DNMT1 | BIRC5 | 17124180 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | BIRC5 | 17848598 19102934 23449974 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EHMT2 | BIRC5 | 17124180 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EP300 | BIRC5 | 19102934 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXO3 | BIRC5 | 22056878 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC1 | BIRC5 | 17124180 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ILF3 | BIRC5 | 22442257 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| LEF1 | BIRC5 | 19620402 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYCN | BIRC5 | 22703967 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | BIRC5 | 14739605 17553314 20126979 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RB1 | BIRC5 | 18504435 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | BIRC5 | 14739605 17553314 20126979 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | BIRC5 | 17124180 22334592 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | BIRC5 | 22334592 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP4 | BIRC5 | 22334592 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF7L2 | BIRC5 | 19131553 19662654 19778454 20331626 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF4 | BIRC5 | 19131553 19662654 19778454 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP73 | BIRC5 | 19067706 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004DA9DB | BIRC5 | 22306317 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000237AF9 | BIRC5 | 23232114 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00004F859B | BIRC5 | 20728447 | rna interference,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000019D79B | BIRC5 | 21852381 22743998 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRDeathDB,TarBase |
| URS00004F859B | BIRC5 | 20728447 25046253 25416803 26711968 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004DA9DB | BIRC5 | 22306317 22713668 22886454 23073851 25416803 26847520 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | BIRC5 | 23232114 25416803 26318298 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000048BA36 | BIRC5 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000016D2D4 | BIRC5 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000FC8EB | BIRC5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002971AB | BIRC5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | BIRC5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001C770D | BIRC5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000DDD35 | BIRC5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | BIRC5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000EED18 | BIRC5 | 23264087 24068565 25416803 25436980 26318298 28097098 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000040EE1D | BIRC5 | 24520312 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000007D64A | BIRC5 | 24520312 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000016FD1A | BIRC5 | 24613688 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry | TarBase |
| URS000020579D | BIRC5 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C0D3F | BIRC5 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015D23B | BIRC5 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | BIRC5 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | BIRC5 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | BIRC5 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000221168 | BIRC5 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | BIRC5 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000001C659 | BIRC5 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008B558 | BIRC5 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | BIRC5 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000160683 | BIRC5 | 25416803 26234674 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00007455B8 | BIRC5 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B59DF | BIRC5 | 19536157 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | BIRC5 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | BIRC5 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003380CC | BIRC5 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | BIRC5 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001067D1 | BIRC5 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CEB74 | BIRC5 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000057A7C | BIRC5 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000535FDD | BIRC5 | 25416803 26718651 | mrna cleavage,inhibition | western blot | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK2A1 | BIRC5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKACA | BIRC5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AURKC | BIRC5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK1 | BIRC5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PLK1 | BIRC5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AURKB | BIRC5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| AURKA | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | AURKA | 25361965 | interaction type | N/A | PTMCode2 |
| CDK4 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | CDK4 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP7 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | CASP7 | 25361965 | interaction type | N/A | PTMCode2 |
| CDK2 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | CDK2 | 25361965 | interaction type | N/A | PTMCode2 |
| XPO1 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | XPO1 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | CASP3 | 25361965 | interaction type | N/A | PTMCode2 |
| CASP3 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | CDCA8 | 25361965 | interaction type | N/A | PTMCode2 |
| CDCA8 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | USP9X | 25361965 | interaction type | N/A | PTMCode2 |
| USP9X | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | PPP1CA | 25361965 | interaction type | N/A | PTMCode2 |
| PPP1CA | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | HSP90AA1 | 25361965 | interaction type | N/A | PTMCode2 |
| HSP90AA1 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | XIAP | 25361965 | interaction type | N/A | PTMCode2 |
| XIAP | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | EVI5 | 25361965 | interaction type | N/A | PTMCode2 |
| EVI5 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | INCENP | 25361965 | interaction type | N/A | PTMCode2 |
| INCENP | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| DIABLO | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | DIABLO | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC2 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | BIRC2 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC3 | BIRC5 | 25361965 | interaction type | N/A | PTMCode2 |
| BIRC5 | BIRC3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HBZ | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CC | BIRC5 | 25348397 | N/A | physical interaction,antibody array | ComPPI |
| RAN | BIRC5 | 23251006 24234451 25348397 | physical association | anti bait coimmunoprecipitation,pull down,physical interaction,enzyme linked immunosorbent assay,proximity ligation assay | ComPPI,IntAct |
| XIAP | BIRC5 | 14525934 15218035 24083380 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| CASP9 | BIRC5 | 11024045 11069302 14525934 24234451 25241761 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| LAMTOR4 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| MED21 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| H2BC4 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| CCDC85B | BIRC5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MED8 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| CASP3 | BIRC5 | 14525934 25348397 9850056 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PRKDC | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| MED1 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| AIP | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | BIRC5 | 14525934 15894266 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| F2RL1 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| CASP7 | BIRC5 | 11024045 11170436 14525934 25348397 9850056 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| XRCC6 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| USF2 | BIRC5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| XPO1 | BIRC5 | 14525934 17099693 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| TRAP1 | BIRC5 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| CDK2 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| H3-4 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| MED22 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| MED30 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| RASA1 | BIRC5 | 11976319 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| H3C15 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| EVI5 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| HDAC6 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| AURKA | BIRC5 | 19357306 24234451 25348397 | phosphorylation reaction,association | anti tag coimmunoprecipitation,phosphorylation reaction,physical interaction,protein kinase assay | ComPPI,IntAct |
| MED17 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| MDC1 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| PYCARD | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| DIABLO | BIRC5 | 12660240 14525934 23251006 24234451 25348397 | N/A | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| PRKN | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| MED14 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| BECN1 | BIRC5 | 20638385 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct,OmniPath |
| KCNJ6 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC2 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC3 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | INCENP | 11516652 14525934 16239925 17099693 17956729 21051298 21225229 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation in solution,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid | ComPPI,HPRD,IntAct |
| BIRC5 | AURKB | 11516652 12419797 14525934 16291752 17099693 17681274 19357306 21051298 24234451 24571573 25348397 27332895 29568061 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,phosphorylation reaction,physical interaction,protein kinase assay,in vitro,in vivo,proximity ligation assay,proximity-dependent biotin identification,two hybrid | ComPPI,HPRD,IntAct |
| BIRC5 | CDCA8 | 14525934 15249581 15260989 17099693 17956729 18243099 20739936 21051298 24234451 25348397 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation in solution,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,fluorescence microscopy,footprinting,in vitro,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| BIRC5 | CDK4 | 10713676 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| BIRC5 | BIRC6 | 14525934 18329369 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BIRC5 | USP9X | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | UFD1 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | H2AX | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | AURKC | 21988832 24234451 25348397 27332895 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,fluorescence microscopy | ComPPI,IntAct |
| BIRC5 | H2BC11 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | FBXL7 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | CCDC102A | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | SSC5D | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | MED6 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | MED10 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | MED31 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | MED29 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | MED20 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | MED4 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | GPX4 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| BIRC5 | PTCD1 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| BIRC5 | NSUN4 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| BIRC5 | DNAJC19 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| BIRC5 | COQ7 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| BIRC5 | CLPP | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| BIRC5 | CDK1 | 11069302 11861764 14525934 17681274 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,experimental interaction detection,fluorescence microscopy | ComPPI,HPRD,IntAct |
| BIRC5 | JTB | 21225229 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| BIRC5 | GAS2L3 | 24234451 24571573 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down | ComPPI,IntAct |
| RAB11B | BIRC5 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| MED18 | BIRC5 | 25348397 | N/A | physical interaction | ComPPI |
| BIRC5 | BIRC5 | 14525934 15688031 16291752 17099693 23251006 24234451 | physical association | experimental interaction detection,pull down | HPRD,IntAct |
| PRKACA | BIRC5 | 17612487 20427271 21148584 24069188 27898060 | N/A | N/A | OmniPath |
| PLK1 | BIRC5 | 21148584 27898060 | stimulant | N/A | OmniPath |
| BIRC5 | AURKB | 11516652 12419797 16291752 17099693 17681274 18477699 19287963 19357306 19951914 19995937 20430883 21554500 27898060 | stimulant | N/A | OmniPath |
| AURKB | BIRC5 | 11516652 12419797 14610074 16291752 17099693 17457057 17681274 18477699 19357306 19951914 19995937 20430883 21554500 27898060 | inhibition | N/A | OmniPath |
| BIRC5 | CASP7 | 11024045 11170436 27898060 9384571 9850056 | inhibition | N/A | OmniPath |
| BIRC5 | CASP3 | 10587640 11024045 11170436 16540654 27898060 9384571 9850056 | inhibition,stimulant | N/A | OmniPath |
| BIRC5 | CASP9 | 11024045 11069302 25241761 27898060 | inhibition | N/A | OmniPath |
| BIRC5 | XIAP | 15218035 17613533 21536684 24083380 27898060 | stimulant | N/A | OmniPath |
| MAP3K5 | BIRC5 | 16540654 27898060 | N/A | N/A | OmniPath |
| TP53 | BIRC5 | 11714700 27898060 | inhibition | N/A | OmniPath |
| CDK1 | BIRC5 | 11069302 11149963 11861764 12517802 12529428 15735703 15894279 16170024 16565220 17681274 18691976 18949405 19287963 20068231 24478433 25468890 27898060 | stimulant | N/A | OmniPath |
| SP1 | BIRC5 | 19120021 27898060 | stimulant | N/A | OmniPath |
| BIRC5 | BIRC2 | 15218035 15665297 25635055 27898060 | N/A | N/A | OmniPath |
| BIRC3 | BIRC5 | 15218035 27898060 | N/A | N/A | OmniPath |
| CSNK2A1 | BIRC5 | 21252625 27898060 | N/A | N/A | OmniPath |
| BIRC5 | DIABLO | 10929711 12660240 15541727 16540654 17546047 21536684 23251006 27898060 | inhibition | N/A | OmniPath |
| DIABLO | BIRC5 | 10929711 12660240 15541727 16540654 17546047 21536684 23251006 27898060 | inhibition | N/A | OmniPath |