GENE：FGF10
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FGF10 |
| FullNmae | fibroblast growth factor 10 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3666 |
| EnsembleID | ENSG00000070193 |
| Uniprot | O15520 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FGF10 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FGF10 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FGF10 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FGF10 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FGF10 | GO:0000132,GO:0001525,GO:0001656,GO:0001759,GO:0001823,GO:0001934,GO:0001935,GO:0001938,GO:0001974,GO:0003338,GO:0005104,GO:0005111,GO:0005111,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005737,GO:0005886,GO:0007368,GO:0007431,GO:0008083,GO:0008083,GO:0008201,GO:0008589,GO:0009880,GO:0009887,GO:0009986,GO:0009986,GO:0010628,GO:0010634,GO:0010634,GO:0010838,GO:0016055,GO:0021983,GO:0030036,GO:0030154,GO:0030538,GO:0030857,GO:0030878,GO:0030916,GO:0030949,GO:0031016,GO:0031069,GO:0031076,GO:0032355,GO:0032496,GO:0032781,GO:0032808,GO:0032925,GO:0034394,GO:0035019,GO:0042056,GO:0042056,GO:0042060,GO:0042060,GO:0042246,GO:0042475,GO:0042693,GO:0043410,GO:0043616,GO:0045739,GO:0045747,GO:0045944,GO:0046579,GO:0046877,GO:0048010,GO:0048144,GO:0048146,GO:0048536,GO:0048538,GO:0048557,GO:0048754,GO:0048807,GO:0048808,GO:0050671,GO:0050673,GO:0050674,GO:0050677,GO:0050679,GO:0050679,GO:0050731,GO:0050872,GO:0050918,GO:0050918,GO:0050930,GO:0051145,GO:0051549,GO:0060019,GO:0060054,GO:0060173,GO:0060174,GO:0060428,GO:0060430,GO:0060436,GO:0060447,GO:0060449,GO:0060496,GO:0060510,GO:0060513,GO:0060595,GO:0060595,GO:0060615,GO:0060661,GO:0060664,GO:0060665,GO:0060667,GO:0060879,GO:0060915,GO:0061033,GO:0061033,GO:0061115,GO:0062023,GO:0070075,GO:0070343,GO:0070352,GO:0070371,GO:0070374,GO:0070384,GO:0071338,GO:0072089,GO:0090263,GO:0097192,GO:1900087,GO:2000647,GO:2000648,GO:2001240 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FGF10 | hsa:2255 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| FGF10 | hsa:2255 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | FGF10 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | FGF10 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FGF10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FGF10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FGF10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FGF10 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA4 | FGF10 | 22303449 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ISL1 | FGF10 | 22303449 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TBX20 | FGF10 | 22303449 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | FGF10 | 18185580 23824327 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS000040EC3B | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000544FF1 | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000331800 | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0920 | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | FGF10 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HBD | FGF10 | 25348397 | N/A | physical interaction | ComPPI |
| SREK1IP1 | FGF10 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| FGFR2 | FGF10 | 12591959 24234451 25241761 25348397 | physical association | affinity chromatography technology,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay | ComPPI,IntAct |
| POMC | FGF10 | 12591959 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| FGF10 | H1-1 | 25348397 | N/A | physical interaction | ComPPI |
| FGF10 | RPL26L1 | 25348397 | N/A | physical interaction | ComPPI |
| FGF10 | SIRT1 | 25348397 | N/A | physical interaction | ComPPI |
| FGF10 | ITIH2 | 25348397 | N/A | physical interaction | ComPPI |
| FGF10 | FGFR1 | 25348397 | N/A | physical interaction | ComPPI |
| FGF10 | THAP1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MANF | FGF10 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| GATA3 | FGF10 | 16806848 27898060 | stimulant | N/A | OmniPath |
| SIX1 | FGF10 | 12874121 27898060 | stimulant | N/A | OmniPath |
| FGF9 | FGF10 | 27898060 8663044 | stimulant | N/A | OmniPath |
| FGF10 | FGFR2 | 12591959 25241761 27898060 8663044 9582367 | stimulant | N/A | OmniPath |