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GENE：HSPA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HSPA2
FullNmae heat shock protein family A (Hsp70) member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5235
EnsembleID ENSG00000126803
Uniprot P54652

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HSPA2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HSPA2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HSPA2 GO:0000795,GO:0001673,GO:0001934,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0006986,GO:0007140,GO:0007141,GO:0007283,GO:0007286,GO:0009408,GO:0009409,GO:0009986,GO:0010971,GO:0016020,GO:0016887,GO:0019899,GO:0031072,GO:0036128,GO:0042026,GO:0042026,GO:0044183,GO:0048156,GO:0051082,GO:0051085,GO:0051087,GO:0051861,GO:0070062,GO:0070194,GO:0072562,GO:0072687,GO:0090084,GO:0097718,GO:0140662

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HSPA2 hsa:3306 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
HSPA2 hsa:3306 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMARCA4 HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HSPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 HSPA2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 HSPA2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D HSPA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001067D1 HSPA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000157FBE HSPA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 HSPA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 HSPA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 HSPA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 HSPA2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC73 HSPA2 25348397 N/A physical interaction ComPPI
TRIM38 HSPA2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSPA8 HSPA2 24234451 25348397 29568061 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HSPA2 HSPBP1 14525934 16189514 16713569 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
HSPA2 EWSR1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
HSPA2 MAP3K3 14525934 1474216 14743216 24234451 25348397 physical association experimental interaction detection,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
HSPA2 CDK9 25348397 N/A physical interaction ComPPI
HSPA2 MEPCE 25348397 N/A physical interaction ComPPI
HSPA2 HNRNPA1 25348397 N/A physical interaction ComPPI
HSPA2 COP1 25348397 N/A physical interaction ComPPI
HSPA2 BAP1 25348397 N/A physical interaction ComPPI
HSPA2 PARP2 25348397 N/A physical interaction ComPPI
HSPA2 PARP1 25348397 N/A physical interaction ComPPI
HSPA2 NCOA2 25348397 N/A physical interaction ComPPI
HSPA2 PSMA3 25348397 N/A physical interaction ComPPI
HSPA2 SIRT7 25348397 N/A physical interaction ComPPI
HSPA2 FBXO25 25348397 N/A physical interaction ComPPI
HSPA2 APP 25348397 N/A physical interaction ComPPI
HSPA2 EEF1A1 25348397 N/A physical interaction ComPPI
HSPA2 HSPA1A 25348397 N/A physical interaction ComPPI
HSPA2 HSPA1B 25348397 N/A physical interaction ComPPI
HSPA2 HSP90AA1 25348397 N/A physical interaction ComPPI
HSPA2 PPP1CC 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
HSPA2 NOS2 25348397 N/A physical interaction ComPPI
HSPA2 MAP1LC3A 25348397 N/A physical interaction ComPPI
HSPA2 CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA2 HDAC6 25348397 N/A physical interaction ComPPI
HSPA2 BAG3 25348397 N/A physical interaction ComPPI
HSPA2 EGFR 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HSPA2 PRKN 25348397 N/A physical interaction ComPPI
HSPA2 BAG4 24234451 25036637 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,two hybrid prey pooling approach ComPPI,IntAct
HSPA2 STUB1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA2 AURKA 25348397 N/A physical interaction ComPPI
HSPA2 CDKN1A 25348397 N/A physical interaction ComPPI
HSPA2 CEP250 25348397 N/A physical interaction ComPPI
HSPA2 CEP57 25348397 N/A physical interaction ComPPI
HSPA2 HAUS2 25348397 N/A physical interaction ComPPI
HSPA2 CEP76 25348397 N/A physical interaction ComPPI
HSPA2 SAE1 25348397 N/A physical interaction ComPPI
HSPA2 TP53 25348397 N/A physical interaction ComPPI
HSPA2 SIRT6 25348397 N/A physical interaction ComPPI
HSPA2 SIK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA2 GRPEL1 25348397 N/A physical interaction ComPPI
HSPA2 HSPA9 25348397 N/A physical interaction ComPPI
HSPA2 HSPH1 24234451 25036637 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
HSPA2 STIP1 25348397 N/A physical interaction ComPPI
HSPA2 NCOA1 25348397 N/A physical interaction ComPPI
HSPA2 PTEN 25348397 N/A physical interaction ComPPI
HSPA2 DNAJC7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA2 AKAP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA2 GAN 25348397 N/A physical interaction ComPPI
HSPA2 ALKBH3 25348397 N/A physical interaction ComPPI
HSPA2 MCM2 25348397 N/A physical interaction ComPPI
HSPA2 MCM5 25348397 N/A physical interaction ComPPI
HSPA2 FAF1 25348397 N/A physical interaction ComPPI
HSPA2 BAG6 25348397 N/A physical interaction ComPPI
HSPA2 PPM1B 25348397 N/A physical interaction ComPPI
HSPA2 ILK 25348397 N/A physical interaction ComPPI
HSPA2 RNF34 25348397 N/A physical interaction ComPPI
HSPA2 FZR1 25348397 N/A physical interaction ComPPI
HSPA2 TRIM25 25348397 N/A physical interaction ComPPI
HSPA2 ESR1 25348397 N/A physical interaction ComPPI
HSPA2 RIPK2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPA2 TAB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPA2 PSMD2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSPA2 PFDN5 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSPA2 TTC1 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSPA2 STK4 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
HSPA2 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPA2 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
HSPA2 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HSPA2 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
HSPA2 CDK1 14525934 9247342 N/A experimental interaction detection HPRD
TANK HSPA2 24234451 30561431 association virotrap IntAct
HSPA2 MAP3K5 12391142 27898060 inhibition N/A OmniPath

Visualization










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