GENE：KDM6A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KDM6A |
| FullNmae | lysine demethylase 6A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12637 |
| EnsembleID | ENSG00000147050 |
| Uniprot | O15550 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KDM6A | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KDM6A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KDM6A | GO:0000978,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0007507,GO:0010468,GO:0031490,GO:0032452,GO:0035097,GO:0044666,GO:0044666,GO:0044666,GO:0046872,GO:0071557,GO:0071558 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| KDM6A | hsa:7403 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | KDM6A | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | KDM6A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | KDM6A | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | KDM6A | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | KDM6A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000011A030 | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000458AD2 | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A9FB9 | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0BB4 | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000009265 | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058863C | KDM6A | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GOLGA2 | KDM6A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DPY30 | KDM6A | 17178841 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TLE1 | KDM6A | 14525934 25348397 9854018 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| AR | KDM6A | 22722839 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAFB | KDM6A | 25348397 | N/A | physical interaction | ComPPI |
| PAXIP1 | KDM6A | 17178841 17500065 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SRF | KDM6A | 25348397 | N/A | physical interaction | ComPPI |
| SMAD9 | KDM6A | 15231748 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| KMT2D | KDM6A | 17178841 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NCOA6 | KDM6A | 17178841 19047629 19433796 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SMARCA4 | KDM6A | 25348397 | N/A | physical interaction | ComPPI |
| ASH2L | KDM6A | 17178841 24234451 25348397 | colocalization,association | anti bait coimmunoprecipitation,molecular sieving,physical interaction | ComPPI,IntAct |
| HNRNPL | KDM6A | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | N4BP2 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | PPP6R3 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | ZNF281 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | RBBP5 | 17178841 17500065 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KDM6A | H3-4 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | NKX2-5 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | GATA4 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | H3C15 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | MAFA | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | RNF2 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | EYA2 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | ARHGAP22 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | FOXA1 | 25348397 | N/A | physical interaction | ComPPI |
| KDM6A | POU5F1 | 22801502 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KDM6A | KLF4 | 22801502 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KDM6A | MATR3 | 17178841 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SOX2 | KDM6A | 22801502 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| H3C1 | KDM6A | 25348397 | N/A | physical interaction | ComPPI |
| WDR5 | KDM6A | 17178841 24234451 25348397 27705803 | association | anti bait coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| KDM6A | RB1 | 20123895 27898060 | stimulant | N/A | OmniPath |
| KDM6A | H3C1 | 20123895 27898060 | stimulant | N/A | OmniPath |