GENE：TGFB2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TGFB2 |
| FullNmae | transforming growth factor beta 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11768 |
| EnsembleID | ENSG00000092969 |
| Uniprot | P61812 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TGFB2 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TGFB2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TGFB2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TGFB2 | apoptosis | 40080329 | These findings reveal that TGFB2 knockdown mitigates ischemic HF by suppressing apoptosis, offering novel insights into the fundamental molecular mechanisms underlying HF. | retulator signature |
| TGFB2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TGFB2 | GO:0000902,GO:0001501,GO:0001540,GO:0001654,GO:0001666,GO:0001822,GO:0001837,GO:0001837,GO:0001843,GO:0001942,GO:0001942,GO:0003007,GO:0003148,GO:0003149,GO:0003179,GO:0003181,GO:0003184,GO:0003203,GO:0003215,GO:0003222,GO:0003274,GO:0003289,GO:0003407,GO:0005102,GO:0005114,GO:0005114,GO:0005114,GO:0005125,GO:0005160,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0006468,GO:0007179,GO:0007179,GO:0007435,GO:0007507,GO:0008083,GO:0008284,GO:0008285,GO:0008347,GO:0008584,GO:0009611,GO:0009792,GO:0010002,GO:0010629,GO:0010634,GO:0010693,GO:0010718,GO:0010936,GO:0016477,GO:0016525,GO:0023052,GO:0030097,GO:0030199,GO:0030307,GO:0030308,GO:0030326,GO:0030424,GO:0030593,GO:0031069,GO:0031093,GO:0032147,GO:0032570,GO:0032874,GO:0032909,GO:0033630,GO:0034714,GO:0034714,GO:0035910,GO:0042060,GO:0042127,GO:0042127,GO:0042416,GO:0042476,GO:0042704,GO:0042803,GO:0043025,GO:0043525,GO:0045216,GO:0045726,GO:0045747,GO:0045787,GO:0045823,GO:0046580,GO:0048103,GO:0048566,GO:0048666,GO:0048699,GO:0048839,GO:0050680,GO:0050680,GO:0050714,GO:0050778,GO:0051781,GO:0051794,GO:0051795,GO:0051891,GO:0051897,GO:0060038,GO:0060065,GO:0060317,GO:0060395,GO:0060412,GO:0060413,GO:0061626,GO:0062009,GO:0062023,GO:0097191,GO:1902256,GO:1902895,GO:1903701,GO:1904888,GO:1905006,GO:1905007 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TGFB2 | hsa:7042 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04110 | Cell cycle - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05144 | Malaria - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05321 | Inflammatory bowel disease - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
| TGFB2 | hsa:7042 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TGFB2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ATF1 | TGFB2 | 11776974 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| ESR1 | TGFB2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | TGFB2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TGFB2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | TGFB2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | TGFB2 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | TGFB2 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| USF1 | TGFB2 | 11776974 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| USF2 | TGFB2 | 11776974 8943301 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TGFB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF2 | TGFB2 | 1400310 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | TGFB2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | TGFB2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | TGFB2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003E1A9 | TGFB2 | 18483486 | rna interference,inhibition | experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000003E1A9 | TGFB2 | 18483486 25416803 28115163 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | TGFB2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000ED600 | TGFB2 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | TGFB2 | 18591254 25416803 27388239 | mrna cleavage,inhibition | array technology,miRNA interference luciferase reporter assay | TarBase |
| URS00001E3523 | TGFB2 | 24465609 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000000EF0B | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0BB4 | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000482389 | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CCA6E | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000480E22 | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000043B1D | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B1B47 | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025307A | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000328C0D | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000451A1 | TGFB2 | 23824327 25416803 27855367 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS000075AB14 | TGFB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000367985 | TGFB2 | 25416803 26822621 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000008DA94 | TGFB2 | 25416803 27267902 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00003BBF48 | TGFB2 | 25416803 26983401 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00001E0AEA | TGFB2 | 25416803 25586666 | mrna cleavage,inhibition | western blot | TarBase |
| URS00001CC864 | TGFB2 | 25416803 27388239 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000183BED | TGFB2 | 25416803 27388239 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00004F4657 | TGFB2 | 25416803 27388239 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VASN | TGFB2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| TGFB1 | TGFB2 | 25348397 | N/A | in vivo | ComPPI |
| TGFBR2 | TGFB2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| VTN | TGFB2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| PZP | TGFB2 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| CCN2 | TGFB2 | 25348397 | N/A | in vivo | ComPPI |
| TGFB2 | TGFB3 | 25348397 | N/A | in vivo | ComPPI |
| TGFB2 | FMOD | 25348397 | N/A | in vitro | ComPPI |
| TGFB2 | TGFBR3 | 25348397 | N/A | coimmunoprecipitation,physical interaction,biochemical,in vivo | ComPPI |
| TGFB2 | BMP2 | 24234451 25241761 25348397 27898060 9493905 | physical association | physical interaction,in vivo,proximity ligation assay | ComPPI,IntAct,OmniPath |
| TGFB2 | ENG | 25348397 | N/A | in vitro,in vivo | ComPPI |
| TGFB2 | FBN1 | 25348397 | N/A | pull down | ComPPI |
| TGFB2 | DCN | 25348397 | N/A | physical interaction | ComPPI |
| TGFB2 | CEBPA | 25348397 | N/A | physical interaction | ComPPI |
| TGFB2 | APP | 2119582 24234451 25241761 25348397 | association,physical association | anti bait coimmunoprecipitation,protein cross-linking with a bifunctional reagent,chromatography technology,physical interaction,competition binding,proximity ligation assay | ComPPI,IntAct |
| TGFB2 | TGFBR1 | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| TGFB2 | KDM5B | 24234451 24937458 | association | chromatin immunoprecipitation assay | IntAct |
| TGFB2 | TGFBR2 | 11157754 1310899 1644679 27898060 8106553 | stimulant | N/A | OmniPath |
| TGFB2 | TGFBR3 | 10519421 10746731 11157754 12809600 27898060 8041735 9312157 | stimulant | N/A | OmniPath |
| TGFB2 | TGFBR1 | 10187774 11157754 22326956 27898060 | stimulant | N/A | OmniPath |
| A2M | TGFB2 | 27898060 9780213 | N/A | N/A | OmniPath |