GENE：ATP7A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATP7A |
| FullNmae | ATPase copper transporting alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:869 |
| EnsembleID | ENSG00000165240 |
| Uniprot | Q04656 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATP7A | pyroptosis | 40318529 | This study demonstrated the neuroprotective effect of 10-HDA in TBI and uncovered a novel molecular mechanism, showing that 10-HDA reduces copper-mediated neuronal pyroptosis by regulating ATP7A expression rather than cuproptosis. | retulator signature |
| ATP7A | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATP7A | cuproptosis | 39567558 | Inhibiting copper transporter ATPase (ATP7A) was found to disrupt copper ion homeostasis, thereby enhancing the effect of cuproptosis and eventually inhibiting tumor invasion and metastasis. | retulator signature |
| ATP7A | cuproptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| ATP7A | cuproptosis | 37864891 | Notably, when Elesclomol and copper were conjoined, copper accumulated within the mitochondria due to the depletion of ATP7A . This sequestration, in turn, facilitated the build-up of reactive oxygen species (ROS), thereby instigating the degradation of SLC7A11 | Driver |
| ATP7A | cuproptosis | 36882769 | The copper was transported to another side of epithelium through copper chaperone antioxidant 1 copper chaperone (ATOX1) and exported into the bloodstream through the action of ATPase copper transporting alpha (ATP7A) | copper transport |
| ATP7A | cuproptosis | 36882769 | ATPases, including ATP7A and ATP7B, associated with the extracellular excretion of copper, export Cu ions bound to metal binding sites in the presence of ATP. | excretion of copper |
| ATP7A | cuproptosis | 36882769 | knock out lead to intracellular copper accumulation | Driver |
| ATP7A | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| ATP7A | cuproptosis | 38348451 | Encode copper transport proteins located on the cell membrane | CRGs in the cuproptosis pathway |
| ATP7A | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.19 database. |
| ATP7A | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.39 database. |
| ATP7A | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| ATP7A | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| ATP7A | cuproptosis | 36118866 | Inhibitor | cuproptosis gene |
| ATP7A | cuproptosis | 36685880 | A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. | cuproptosis-related genes |
| ATP7A | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
| ATP7A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATP7A | GO:0001568,GO:0001701,GO:0001889,GO:0001974,GO:0002082,GO:0005375,GO:0005507,GO:0005507,GO:0005515,GO:0005524,GO:0005524,GO:0005770,GO:0005783,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005886,GO:0005902,GO:0006568,GO:0006584,GO:0006825,GO:0006878,GO:0007005,GO:0007565,GO:0007595,GO:0007626,GO:0010041,GO:0010042,GO:0010043,GO:0010273,GO:0010592,GO:0014069,GO:0015677,GO:0016020,GO:0016020,GO:0016323,GO:0016324,GO:0016532,GO:0016887,GO:0018205,GO:0019430,GO:0021702,GO:0021860,GO:0021954,GO:0030140,GO:0030141,GO:0030198,GO:0030199,GO:0030424,GO:0030425,GO:0030670,GO:0031069,GO:0031252,GO:0031267,GO:0031526,GO:0031901,GO:0032588,GO:0032767,GO:0032767,GO:0032773,GO:0033162,GO:0034760,GO:0036120,GO:0042093,GO:0042414,GO:0042415,GO:0042417,GO:0042428,GO:0043005,GO:0043025,GO:0043085,GO:0043204,GO:0043473,GO:0043588,GO:0043682,GO:0043682,GO:0045793,GO:0048023,GO:0048251,GO:0048286,GO:0048471,GO:0048812,GO:0050679,GO:0051087,GO:0051216,GO:0051542,GO:0055070,GO:0060003,GO:0060003,GO:0071230,GO:0071236,GO:0071276,GO:0071279,GO:0071280,GO:0071281,GO:0071284,GO:0071456,GO:0140581,GO:1903036,GO:1903136,GO:1903136,GO:1904754 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATP7A | hsa:538 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| ATP7A | hsa:538 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | ATP7A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ATP7A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATP7A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ATP7A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ATP7A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ATP7A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | ATP7A | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000521626 | ATP7A | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003380CC | ATP7A | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003CF1AD | ATP7A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000005A8ED | ATP7A | 23824327 24038379 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,clip | TarBase |
| URS00002FC5B0 | ATP7A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | ATP7A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | ATP7A | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS00004F24A9 | ATP7A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | ATP7A | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS0000077AED | ATP7A | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS00004719AB | ATP7A | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS00000B7E30 | ATP7A | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS000028DE3F | ATP7A | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS000029D793 | ATP7A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000572E11 | ATP7A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028D811 | ATP7A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CLU | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| PLK1 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| DNAJB2 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| GLRX | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| COG5 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | ATP7A | 10497213 10557326 12679332 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PDZD11 | ATP7A | 16051599 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,two hybrid,two hybrid array,two hybrid pooling approach | ComPPI,IntAct,OmniPath |
| COMMD1 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| ACIN1 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| TGOLN2 | ATP7A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| CLEC2D | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| C3AR1 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| RPS27 | ATP7A | 25348397 | N/A | physical interaction | ComPPI |
| ATP7A | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| ATP7A | CD83 | 25348397 | N/A | physical interaction | ComPPI |
| ATP7A | NCR3LG1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP7A | ITM2A | 25348397 | N/A | physical interaction | ComPPI |
| ATP7A | HNRNPD | 24234451 30021884 | physical association | cross-linking study | IntAct |
| CP | ATP7A | 11040994 27898060 | N/A | N/A | OmniPath |