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GENE：GPX2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GPX2
FullNmae glutathione peroxidase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4554
EnsembleID ENSG00000176153
Uniprot P18283

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GPX2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GPX2 GO:0004602,GO:0005737,GO:0005829,GO:0005829,GO:0006979,GO:0009055,GO:0022900,GO:0045171,GO:0072686,GO:0098869

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GPX2 hsa:2877 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GPX2 hsa:2877 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GPX2 hsa:2877 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
GPX2 hsa:2877 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
GPX2 hsa:2877 path:hsa05016 Huntington disease - Homo sapiens (human)
GPX2 hsa:2877 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 GPX2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 GPX2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GPX2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFE2L2 GPX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GPX2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002075FA GPX2 21203553 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00002075FA GPX2 21203553 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 GPX2 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PSMB2 GPX2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MYC GPX2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GPX2 TP53 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct

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