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GENE：THBS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol THBS1
FullNmae thrombospondin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11785
EnsembleID ENSG00000137801
Uniprot P07996

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
THBS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
THBS1 apoptosis 39796249 By integrating this finding with related studies, we were able to ascertain that THBS1 exerts a significant influence on the level of cell proliferation and apoptosis. retulator signature
THBS1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
THBS1 GO:0001666,GO:0001786,GO:0001937,GO:0001937,GO:0001953,GO:0001968,GO:0002020,GO:0002040,GO:0002544,GO:0002581,GO:0002605,GO:0004866,GO:0005178,GO:0005201,GO:0005201,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005577,GO:0005615,GO:0005615,GO:0005783,GO:0005788,GO:0006915,GO:0006954,GO:0006955,GO:0006986,GO:0007155,GO:0008201,GO:0008284,GO:0008285,GO:0009410,GO:0009612,GO:0009749,GO:0009897,GO:0009986,GO:0010595,GO:0010596,GO:0010748,GO:0010751,GO:0010754,GO:0010757,GO:0010759,GO:0010763,GO:0016477,GO:0016525,GO:0016525,GO:0016525,GO:0016529,GO:0017134,GO:0018149,GO:0030141,GO:0030169,GO:0030194,GO:0030335,GO:0030335,GO:0030511,GO:0031012,GO:0031091,GO:0031093,GO:0032026,GO:0032570,GO:0032695,GO:0032760,GO:0032914,GO:0033574,GO:0034605,GO:0034976,GO:0040037,GO:0042327,GO:0042803,GO:0043032,GO:0043066,GO:0043154,GO:0043236,GO:0043394,GO:0043406,GO:0043536,GO:0043537,GO:0043652,GO:0045727,GO:0045766,GO:0048266,GO:0048661,GO:0050431,GO:0050431,GO:0050921,GO:0051592,GO:0051895,GO:0051897,GO:0051918,GO:0062023,GO:0062023,GO:0062023,GO:0062023,GO:0070051,GO:0070052,GO:0070062,GO:0071356,GO:0071363,GO:0090051,GO:1902043,GO:1903588,GO:1903671,GO:2000353,GO:2000379,GO:2001027,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
THBS1 hsa:7057 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04145 Phagosome - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04148 Efferocytosis - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04510 Focal adhesion - Homo sapiens (human)
THBS1 hsa:7057 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
THBS1 hsa:7057 path:hsa05144 Malaria - Homo sapiens (human)
THBS1 hsa:7057 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
THBS1 hsa:7057 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
THBS1 hsa:7057 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
THBS1 hsa:7057 path:hsa05219 Bladder cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
THBS1 CD47 10657674 11509594 11982756 14568985 14996710 20150200015 22310103 22943793 26192618 8349738 association N/A ACSN
THBS1 CD36 10657674 11982756 14568985 14996710 17101731 20150200015 21378271 22943793 26192618 8349738 9295024 9763615 association N/A ACSN
THBS1 KDR 10657674 11982756 14568985 14996710 22943793 26192618 8349738 interaction type N/A ACSN
THBS1 VEGFA 10657674 11982756 14568985 14996710 22943793 26192618 8349738 interaction type N/A ACSN
THBS1 VEGFB 10657674 11982756 14568985 14996710 22943793 26192618 8349738 interaction type N/A ACSN
THBS1 MAP2K4 10657674 10811870 11257133 11823516 11982756 14568985 14996710 19090789 20531300 22943793 23170255 23510023 25001536 26192618 26819959 28258062 8349738 8777713 9242610 9858524 interaction type N/A ACSN
THBS1 LTBP1 10657674 11982756 14568985 14996710 21900405 22943793 26192618 8349738 interaction type N/A ACSN
THBS1 TGFB1 10657674 11982756 14568985 14996710 21900405 22943793 26192618 8349738 interaction type N/A ACSN
IL10 THBS1 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26192618 26755705 9834059 interaction type N/A ACSN
THBS1 SPARC 23180781 3402455 physical association solid phase assay InnateDB
THBS1 ELAVL1 18641687 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
THBS1 E2F1 20976175 23180781 physical association anti tag coimmunoprecipitation InnateDB
PITX3 THBS1 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR THBS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 THBS1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 THBS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 THBS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 THBS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 THBS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPZ THBS1 18275041 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
GC THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TBP THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 THBS1 18971253 20976175 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 THBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 THBS1 21072196 trascriptional regulation,stimulation inferred by curator TFlink
SNAI1 THBS1 19874710 trascriptional regulation,stimulation inferred by curator TFlink
TP53 THBS1 10029407 10101800 19826414 trascriptional regulation,stimulation inferred by curator TFlink
USF2 THBS1 15184388 trascriptional regulation,stimulation inferred by curator TFlink
WT1 THBS1 15542786 15618543 trascriptional regulation,stimulation inferred by curator TFlink
TP73 THBS1 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 THBS1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 THBS1 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000065D58 THBS1 N/A 16239240 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000324096 THBS1 18668040 24398324 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS0000065D58 THBS1 16239240 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 THBS1 17942906 19088304 24398324 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip TarBase
URS00002075FA THBS1 20940405 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000042E1F THBS1 20940405 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000338542 THBS1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000028BB8 THBS1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000006FDD4 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 THBS1 20371350 24398324 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000029979D THBS1 24291274 24398324 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000330617 THBS1 24177325 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001CC379 THBS1 24053448 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004719AB THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005E58C THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E177F THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 THBS1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000027464B THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD THBS1 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 THBS1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 THBS1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 THBS1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 THBS1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 THBS1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000015B295 THBS1 25416803 25660232 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
DCN THBS1 25361965 interaction type N/A PTMCode2
THBS1 DCN 25361965 interaction type N/A PTMCode2
TNFAIP6 THBS1 25361965 interaction type N/A PTMCode2
THBS1 TNFAIP6 25361965 interaction type N/A PTMCode2
MMP2 THBS1 25361965 interaction type N/A PTMCode2
THBS1 MMP2 25361965 interaction type N/A PTMCode2
SPARC THBS1 25361965 interaction type N/A PTMCode2
THBS1 SPARC 25361965 interaction type N/A PTMCode2
TGFB1 THBS1 25361965 interaction type N/A PTMCode2
THBS1 TGFB1 25361965 interaction type N/A PTMCode2
THBS1 ITGB3 25361965 interaction type N/A PTMCode2
ITGB3 THBS1 25361965 interaction type N/A PTMCode2
THBS1 SCARB2 25361965 interaction type N/A PTMCode2
SCARB2 THBS1 25361965 interaction type N/A PTMCode2
THBS1 CD36 25361965 interaction type N/A PTMCode2
CD36 THBS1 25361965 interaction type N/A PTMCode2
THBS1 CALR 25361965 interaction type N/A PTMCode2
CALR THBS1 25361965 interaction type N/A PTMCode2
THBS1 PDGFB 25361965 interaction type N/A PTMCode2
PDGFB THBS1 25361965 interaction type N/A PTMCode2
THBS1 CD47 25361965 interaction type N/A PTMCode2
CD47 THBS1 25361965 interaction type N/A PTMCode2
THBS1 COL5A1 25361965 interaction type N/A PTMCode2
COL5A1 THBS1 25361965 interaction type N/A PTMCode2
THBS1 MMP9 25361965 interaction type N/A PTMCode2
MMP9 THBS1 25361965 interaction type N/A PTMCode2
THBS1 COL4A1 25361965 interaction type N/A PTMCode2
COL4A1 THBS1 25361965 interaction type N/A PTMCode2
THBS1 DHFR 25361965 interaction type N/A PTMCode2
DHFR THBS1 25361965 interaction type N/A PTMCode2
CTSG THBS1 25361965 interaction type N/A PTMCode2
THBS1 CTSG 25361965 interaction type N/A PTMCode2
TFPI THBS1 25361965 interaction type N/A PTMCode2
THBS1 TFPI 25361965 interaction type N/A PTMCode2
IGFBP5 THBS1 25361965 interaction type N/A PTMCode2
THBS1 IGFBP5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CORO1A THBS1 10749676 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TGFB1 THBS1 14525934 1550960 15864306 24234451 25348397 association experimental interaction detection,physical interaction,in vivo,solid phase assay ComPPI,HPRD,IntAct
CTSG THBS1 14525934 25348397 8408036 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD36 THBS1 10487979 10772961 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
VEGFA THBS1 19805200 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ELANE THBS1 14525934 25348397 8463250 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGB1 THBS1 25348397 N/A physical interaction ComPPI
TGM2 THBS1 19542224 24234451 25348397 N/A surface plasmon resonance array ComPPI,IntAct
ITGAV THBS1 25348397 N/A physical interaction ComPPI
PLG THBS1 14525934 2522013 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
F2 THBS1 14525934 2435757 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
SPARC THBS1 14525934 25348397 2745554 27898060 3402455 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
THBS1 ITGB3 14525934 2478219 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
THBS1 LRP1 14525934 14991768 25348397 27898060 7775583 9045712 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
THBS1 PDGFB 14525934 25348397 27898060 9334164 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
THBS1 KNG1 14525934 25348397 27898060 9459346 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
THBS1 CD47 10397731 14525934 25348397 8550562 9169439 N/A experimental interaction detection,in vivo ComPPI,HPRD
THBS1 SCARB2 14525934 25348397 27898060 9478926 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
THBS1 LRP5 14525934 25348397 7775583 N/A experimental interaction detection,in vivo ComPPI,HPRD
THBS1 CALR 12147682 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
THBS1 TNFAIP6 14525934 16006654 18042364 18226512 24234451 25348397 27898060 physical association experimental interaction detection,in vitro,solid phase assay ComPPI,HPRD,IntAct,OmniPath
THBS1 CFH 14525934 15634279 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
THBS1 TNFRSF11B 14525934 15799029 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
THBS1 COL7A1 14525934 25348397 9840442 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
THBS1 COL2A1 14525934 25348397 3571333 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
THBS1 COL1A1 14525934 25348397 3571333 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
THBS1 COL3A1 14525934 25348397 3571333 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
THBS1 MMP2 10900205 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
THBS1 MMP9 10900205 11606713 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
THBS1 DHFR 10749676 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
THBS1 FGA 14525934 25348397 27898060 9867861 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
THBS1 HRG 14525934 25348397 6438154 N/A experimental interaction detection,in vivo ComPPI,HPRD
THBS1 IGFBP5 10698186 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
THBS1 LAMB3 14525934 25348397 9840442 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
THBS1 TFPI 10922378 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
THBS1 FN1 11773026 14525934 18042364 19542224 24234451 25348397 physical association experimental interaction detection,solid phase assay,surface plasmon resonance array ComPPI,HPRD,IntAct
THBS1 FBN1 25348397 N/A pull down ComPPI
THBS1 PCOLCE 24117177 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
THBS1 ECM1 25348397 N/A two hybrid ComPPI
THBS1 LPA 25348397 N/A physical interaction ComPPI
THBS1 COL4A1 25348397 N/A physical interaction ComPPI
THBS1 COL5A1 14525934 25348397 27898060 6693501 9840442 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
THBS1 CALCR 25348397 N/A physical interaction ComPPI
THBS1 LRP2 25348397 N/A physical interaction ComPPI
THBS1 FGF2 25348397 N/A physical interaction ComPPI
THBS1 ELAVL1 25348397 N/A physical interaction ComPPI
THBS1 PSMD4 25348397 N/A physical interaction ComPPI
THBS1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THBS1 THBS4 25348397 N/A physical interaction ComPPI
THBS1 THBS3 25348397 N/A physical interaction ComPPI
THBS1 THBS2 25348397 N/A physical interaction ComPPI
THBS1 FCGRT 25348397 N/A physical interaction ComPPI
THBS1 DDX31 25348397 N/A physical interaction ComPPI
THBS1 YAP1 25348397 N/A physical interaction ComPPI
THBS1 PLEK 19722192 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
THBS1 TUBA1A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SOX2 THBS1 25348397 N/A physical interaction ComPPI
H3C1 THBS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
THBS1 DCN 14525934 1550960 27898060 9328841 N/A experimental interaction detection HPRD,OmniPath
JAG1 THBS1 14525934 15258909 27898060 N/A two hybrid HPRD,OmniPath
THBS1 ITGB1 15292271 27898060 stimulant N/A OmniPath
THBS1 NGF 10708953 27898060 stimulant N/A OmniPath
PRMT6 THBS1 19509293 27898060 inhibition N/A OmniPath
THBS1 ITGA3 10196234 27898060 stimulant N/A OmniPath
THBS1 ITGA2B 2478219 27898060 stimulant N/A OmniPath
THBS1 ITGA4 14699013 27898060 stimulant N/A OmniPath
THBS1 CD47 10397731 11980922 27898060 8550562 9169439 stimulant N/A OmniPath
THBS1 ITGA6 12909644 27898060 stimulant N/A OmniPath

Visualization










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