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GENE：PPARD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPARD
FullNmae peroxisome proliferator activated receptor delta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9235
EnsembleID ENSG00000112033
Uniprot Q03181

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPARD autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPARD apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPARD apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPARD GO:0000122,GO:0000122,GO:0000785,GO:0000785,GO:0000978,GO:0000981,GO:0001223,GO:0001227,GO:0001227,GO:0003677,GO:0003700,GO:0003700,GO:0003707,GO:0004879,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0006006,GO:0006091,GO:0006357,GO:0006629,GO:0006631,GO:0006635,GO:0006635,GO:0006915,GO:0007566,GO:0008203,GO:0008270,GO:0008283,GO:0008289,GO:0008366,GO:0009062,GO:0009755,GO:0010628,GO:0010887,GO:0014842,GO:0015908,GO:0030154,GO:0030522,GO:0031589,GO:0031669,GO:0042060,GO:0043401,GO:0043415,GO:0043616,GO:0045600,GO:0045662,GO:0045892,GO:0045893,GO:0045923,GO:0045944,GO:0046697,GO:0050680,GO:0050728,GO:0051546,GO:0060612,GO:0070341,GO:0070346,GO:0070539,GO:0071456,GO:0097009,GO:0097009,GO:0097190,GO:0140297,GO:1902894,GO:1904659,GO:1990837,GO:2000288

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPARD hsa:5467 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
PPARD hsa:5467 path:hsa04148 Efferocytosis - Homo sapiens (human)
PPARD hsa:5467 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PPARD hsa:5467 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PPARD hsa:5467 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 PPARD 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKB1 PPARD 21763497 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELA PPARD 21763497 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF5 PPARD 23180781 25686501 physical association anti tag coimmunoprecipitation InnateDB
KLF6 PPARD 23180781 25686501 physical association anti tag coimmunoprecipitation InnateDB
KLF9 PPARD 23180781 25686501 physical association anti tag coimmunoprecipitation InnateDB
PPARD RXRB 12576510 15604093 23331499 stimulation N/A SignaLink
PPARD RXRA 12576510 15604093 23331499 stimulation N/A SignaLink
RXRA PPARD 15604093 23331499 9933587 stimulation N/A SignaLink
RXRB PPARD 11237216 15604093 23331499 stimulation N/A SignaLink
PPARD NR1H2 15722453 23331499 stimulation N/A SignaLink
NR1H2 PPARD 15722453 23331499 stimulation N/A SignaLink
NR1H3 PPARD 15722453 23331499 stimulation N/A SignaLink
PPARD NR1H3 15722453 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GADD45B PPARD 20005715 interaction type N/A PSP
GADD45G PPARD 20005715 interaction type N/A PSP
GADD45B PPARD 10872826 18988627 20005715 20005715 N/A N/A SignaLink
GADD45G PPARD 10872826 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PPARD 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 PPARD 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PPARD 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
JUN PPARD 18625220 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PPARD 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PPARD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTNNB1 PPARD 17724465 trascriptional regulation,stimulation inferred by curator TFlink
RELA PPARD 14708613 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001597DC PPARD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003BBF48 PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000521626 PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000C73C PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000016914 PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027080C PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065D58 PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005CF5F PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DE669 PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000028DE3F PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000E601 PPARD 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BCL6 PPARD 25361965 interaction type N/A PTMCode2
PPARD BCL6 25361965 interaction type N/A PTMCode2
HDAC3 PPARD 25361965 interaction type N/A PTMCode2
PPARD HDAC3 25361965 interaction type N/A PTMCode2
PPARD SRC 25361965 interaction type N/A PTMCode2
SRC PPARD 25361965 interaction type N/A PTMCode2
HDAC4 PPARD 25361965 interaction type N/A PTMCode2
PPARD HDAC4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GADD45G PPARD 10872826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
KRTAP10-7 PPARD 25348397 N/A physical interaction ComPPI
STAT1 PPARD 25348397 N/A physical interaction ComPPI
RXRG PPARD 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NRIP1 PPARD 14525934 15001550 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 PPARD 25348397 N/A physical interaction ComPPI
HSP90AB1 PPARD 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SRC PPARD 14525934 15001550 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CREBBP PPARD 21775429 24234451 25348397 N/A amplified luminescent proximity homogeneous assay ComPPI,IntAct
NCOA3 PPARD 25348397 N/A physical interaction ComPPI
NCOA1 PPARD 15604093 15888456 16930961 21775429 24234451 25348397 27898060 N/A physical interaction,amplified luminescent proximity homogeneous assay ComPPI,IntAct,OmniPath
EP300 PPARD 10567538 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
HDAC3 PPARD 11867749 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HDAC4 PPARD 25348397 N/A physical interaction ComPPI
NCOR2 PPARD 25348397 N/A physical interaction,in vitro ComPPI
NCOR1 PPARD 14525934 15001550 21775429 24234451 25348397 N/A experimental interaction detection,physical interaction,in vitro,amplified luminescent proximity homogeneous assay ComPPI,HPRD,IntAct
DUT PPARD 14525934 25348397 8910358 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPARGC1A PPARD 21775429 24234451 25348397 N/A physical interaction,amplified luminescent proximity homogeneous assay ComPPI,IntAct
GADD45B PPARD 10872826 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
UBB PPARD 25348397 N/A physical interaction ComPPI
HSP90AA1 PPARD 25348397 N/A physical interaction ComPPI
SMAD9 PPARD 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PEBP1 PPARD 14525934 15001550 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RELA PPARD 25348397 N/A physical interaction ComPPI
RANBP9 PPARD 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PPARD HDAC2 24234451 25241761 25348397 physical association physical interaction,in vivo,proximity ligation assay ComPPI,IntAct
PPARD SPEN 11867749 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PPARD HDAC7 12970571 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPARD NR0B2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PPARD PRDX6 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PPARD PROX1 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PPARD RXRB 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PPARD HDAC1 11867749 14525934 18037904 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
PPARD NCOA2 21775429 24234451 25348397 N/A physical interaction,amplified luminescent proximity homogeneous assay ComPPI,IntAct
PPARD RXRA 14525934 15604093 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
PPARD SHMT2 25348397 N/A physical interaction ComPPI
PPARD HSP90AA2P 25348397 N/A physical interaction ComPPI
PPARD PSMG1 25348397 N/A physical interaction ComPPI
PPARD KDM1A 23455924 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PPARD PRMT3 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPARD KRTAP10-3 25348397 N/A physical interaction ComPPI
PPARD CEP350 25348397 N/A physical interaction ComPPI
PPARD MDM2 25348397 N/A physical interaction ComPPI
PPARD MDM4 25348397 N/A physical interaction ComPPI
PPARD TRMT6 25348397 N/A physical interaction ComPPI
PPARD RIC8B 25348397 N/A physical interaction ComPPI
PPARD RNF31 25348397 N/A physical interaction ComPPI
PPARD NSMCE4A 25348397 N/A physical interaction ComPPI
PPARD PSMC5 25348397 N/A physical interaction ComPPI
PPARD STAT3 25348397 N/A physical interaction ComPPI
PPARD MC1R 25348397 N/A physical interaction ComPPI
PPARD TUBB3 25348397 N/A physical interaction ComPPI
PPARD TRIM25 25348397 N/A physical interaction ComPPI
GLUL PPARD 25348397 N/A physical interaction ComPPI
TNP1 PPARD 25348397 N/A physical interaction ComPPI
PPARD PPARD 10198642 14525934 N/A experimental interaction detection HPRD
RXRA PPARD 11237216 12576510 1560409 15604093 15888456 19756148 22205725 27898060 9933587 stimulant N/A OmniPath
PPARD RXRA 12576510 1560409 15604093 15888456 19756148 22205725 27898060 9933587 stimulant N/A OmniPath
PPARD RELA 21763497 27898060 N/A N/A OmniPath
NR1H2 PPARD 15722453 27898060 stimulant N/A OmniPath
PPARD NR1H2 15722453 27898060 stimulant N/A OmniPath
RXRB PPARD 11237216 12576510 1560409 15604093 22205725 27898060 stimulant N/A OmniPath
PPARD RXRB 11237216 12576510 1560409 15604093 22205725 27898060 stimulant N/A OmniPath
PPARD NR1H3 15722453 27898060 stimulant N/A OmniPath
NR1H3 PPARD 15722453 27898060 stimulant N/A OmniPath

Visualization










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