GENE：SPARC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SPARC |
| FullNmae | secreted protein acidic and cysteine rich |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11219 |
| EnsembleID | ENSG00000113140 |
| Uniprot | P09486 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SPARC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SPARC | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SPARC | cuproptosis | 38403151 | Further analysis resulted in the identification of 6 CRGs, namely LOX, SPARC, MOXD1, ALB, MT-CO2, and AOC2. | cuproptosis-related genes (CRGs) |
| SPARC | cuproptosis | 38403151 | Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin, is a secreted protein which functions as an extracellular matrix (ECM) glycoprotein and regulates interactions between cells and the ECM, rather than directly contributing to the ECM structure (Kos and Wilding, 2010). SPARC also regarded as copper-binding proteins, involved in the process of tumor invasion and may be involved in tumor therapy by further controlling copper ion levels. | controlling copper ion levels |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SPARC | GO:0001937,GO:0005201,GO:0005509,GO:0005509,GO:0005515,GO:0005518,GO:0005518,GO:0005576,GO:0005576,GO:0005576,GO:0005604,GO:0005615,GO:0005737,GO:0005886,GO:0009986,GO:0010595,GO:0016363,GO:0016525,GO:0022604,GO:0031091,GO:0031092,GO:0031093,GO:0043231,GO:0048856,GO:0050840,GO:0062023,GO:0071682 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TGFBR2 | SPARC | 15034927 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| THBS1 | SPARC | 23180781 3402455 | physical association | solid phase assay | InnateDB |
| SPARC | PLG | 23180781 7514608 7982919 | protein cleavage,physical association | protease assay,solid phase assay | InnateDB |
| SPARC | CASP8 | 17897953 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PDGFA | SPARC | 23180781 9692901 | physical association | surface plasmon resonance array | InnateDB |
| PDGFB | SPARC | 23180781 9692901 | physical association | surface plasmon resonance array | InnateDB |
| SPARC | MMP3 | 12867428 23180781 | protein cleavage | protease assay | InnateDB |
| DNMT1 | SPARC | 18458674 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| STAB1 | SPARC | 16670288 23180781 | physical association | phage display,solid phase assay | InnateDB |
| SPARC | COL3A1 | 19011090 23180781 | physical association | x-ray crystallography | InnateDB |
| FGA | SPARC | 16263253 23180781 | physical association | surface plasmon resonance | InnateDB |
| VTN | SPARC | 23180781 9164872 | physical association | solid phase assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SPARC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SPARC | 20034404 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | SPARC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | SPARC | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SPARC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SATB1 | SPARC | 17343824 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VHL | SPARC | 15824735 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272A3D | SPARC | N/A 18390668 \N | rna interference,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | miRSponge |
| URS0000272A3D | SPARC | 18390668 18927107 21125666 22745231 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | miR2Disease,TarBase |
| URS00000B59A2 | SPARC | 16822819 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000076995 | SPARC | 21880628 22745231 22864815 23023935 25416803 25786138 26199111 | mrna cleavage,inhibition | array technology,experimental interaction detection,nucleotide sequence identification,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000016D2D4 | SPARC | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000045147B | SPARC | 22745231 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000105D19 | SPARC | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005C1F22 | SPARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027464B | SPARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F008 | SPARC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000044FD7 | SPARC | 25416803 27230656 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000024DFCE | SPARC | 25262637 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SPARC | THBS1 | 25361965 | interaction type | N/A | PTMCode2 |
| THBS1 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | CTSK | 25361965 | interaction type | N/A | PTMCode2 |
| CTSK | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | COL1A2 | 25361965 | interaction type | N/A | PTMCode2 |
| COL1A2 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | COL3A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL3A1 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | PDGFB | 25361965 | interaction type | N/A | PTMCode2 |
| PDGFB | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | COL5A1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL5A1 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | HSPG2 | 25361965 | interaction type | N/A | PTMCode2 |
| HSPG2 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| TGFB1 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | TGFB1 | 25361965 | interaction type | N/A | PTMCode2 |
| COL1A1 | SPARC | 25361965 | interaction type | N/A | PTMCode2 |
| SPARC | COL1A1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COL1A2 | SPARC | 14525934 25348397 7034958 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TGFB1 | SPARC | 14525934 15034927 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| MMP3 | SPARC | 12867428 25348397 27898060 | N/A | protease assay | ComPPI,OmniPath |
| TGFBR2 | SPARC | 25348397 | N/A | anti tag coimmunoprecipitation | ComPPI |
| VEGFA | SPARC | 14525934 25348397 27898060 9792673 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| TGM2 | SPARC | 14525934 25348397 27898060 7730416 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| SDC2 | SPARC | 14525934 25348397 2745554 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PLG | SPARC | 14525934 25348397 2745554 27898060 7514608 7982919 | N/A | experimental interaction detection,physical interaction,in vitro,solid phase assay | ComPPI,HPRD,OmniPath |
| PLAT | SPARC | 14525934 25348397 2745554 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SPARC | PDGFA | 1311092 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SPARC | THBS1 | 14525934 25348397 2745554 27898060 3402455 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| SPARC | CTSK | 14525934 25348397 8647860 | N/A | experimental interaction detection,enzymatic study,in vitro | ComPPI,HPRD |
| SPARC | COL2A1 | 14525934 25348397 2745554 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SPARC | COL1A1 | 14525934 25348397 7034958 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| SPARC | COL3A1 | 14525934 19011090 25348397 2745554 27898060 | N/A | experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| SPARC | COL13A1 | 25348397 | N/A | in vitro | ComPPI |
| SPARC | HSPG2 | 14525934 25348397 2745554 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SPARC | VCAM1 | 17178915 25348397 27898060 | N/A | solid phase assay | ComPPI,OmniPath |
| SPARC | ILK | 25348397 | N/A | phage display | ComPPI |
| SPARC | CASP8 | 25348397 | N/A | coimmunoprecipitation | ComPPI |
| SPARC | COL5A1 | 25348397 | N/A | physical interaction | ComPPI |
| SPARC | LPA | 25348397 | N/A | physical interaction | ComPPI |
| SPARC | PDGFB | 25348397 | N/A | physical interaction | ComPPI |
| SPARC | ZNF579 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SPARC | XRCC6 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SPARC | UBQLN1 | 25348397 | N/A | physical interaction | ComPPI |
| SPARC | RASSF7 | 25348397 | N/A | physical interaction | ComPPI |
| SPARC | MYOC | 20926826 24234451 25348397 | physical association | two hybrid,enzyme linked immunosorbent assay | ComPPI,IntAct |
| VTN | SPARC | 25348397 | N/A | solid phase assay | ComPPI |
| SPARC | SPARC | 14525934 2745554 3402455 9233787 | N/A | experimental interaction detection | HPRD |
| SPARC | FN1 | 14525934 2745554 | N/A | experimental interaction detection | HPRD |
| SPARC | PHOSPHO2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SPARC | TBC1D14 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SPARC | ILF3 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| SPARC | LSG1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| FGA | SPARC | 16263253 27898060 | N/A | N/A | OmniPath |
| SPARC | STAB1 | 16670288 27898060 | N/A | N/A | OmniPath |
| SPARC | PDGFA | 1311092 27898060 9692901 | N/A | N/A | OmniPath |
| SPARC | PDGFB | 27898060 9692901 | N/A | N/A | OmniPath |
| SPARC | CASP8 | 17897953 27898060 | N/A | N/A | OmniPath |