GENE：UCP2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | UCP2 |
| FullNmae | uncoupling protein 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12518 |
| EnsembleID | ENSG00000175567 |
| Uniprot | P55851 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| UCP2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| UCP2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| UCP2 | GO:0000266,GO:0000303,GO:0001666,GO:0005515,GO:0005739,GO:0005743,GO:0006096,GO:0006541,GO:0006839,GO:0007565,GO:0008271,GO:0009409,GO:0015078,GO:0015108,GO:0015131,GO:0015140,GO:0015183,GO:0015297,GO:0015740,GO:0017077,GO:0030225,GO:0032869,GO:0034198,GO:0035435,GO:0042803,GO:0043524,GO:0051881,GO:0061179,GO:0070542,GO:0070778,GO:0071284,GO:0071333,GO:0071423,GO:0072593,GO:0097421,GO:0120162,GO:0140787,GO:1902356,GO:1902358,GO:1902476,GO:1902600,GO:1990542,GO:1990542,GO:1990845 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | UCP2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | UCP2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | UCP2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | UCP2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | UCP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | UCP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | UCP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | UCP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | UCP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | UCP2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | UCP2 | 21935467 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | UCP2 | 21344490 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | UCP2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARD | UCP2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARG | UCP2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000171CD1 | UCP2 | 21146880 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000171CD1 | UCP2 | 21146880 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00005651EE | UCP2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000235862 | UCP2 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023BE29 | UCP2 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F1B8C | UCP2 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000383DF4 | UCP2 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002578DA | UCP2 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ANXA1 | UCP2 | 25348397 | N/A | physical interaction | ComPPI |
| KRTAP10-7 | UCP2 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| UCP2 | YWHAZ | 10785390 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| UCP2 | YWHAB | 10785390 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| UCP2 | YWHAG | 10785390 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| UCP2 | KRTAP10-3 | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | FLG | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | SERPINB4 | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | MUC7 | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | HAL | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | PIGR | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | SERPINB3 | 25348397 | N/A | physical interaction | ComPPI |
| UCP2 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | UCP2 | 10785390 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009AFE59 | UCP2 | 27087310 | direct interaction,inhibition | N/A | NPInter |