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GENE：CASK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASK
FullNmae calcium/calmodulin dependent serine protein kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1497
EnsembleID ENSG00000147044
Uniprot O14936

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASK autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CASK GO:0001953,GO:0004385,GO:0004674,GO:0005102,GO:0005515,GO:0005516,GO:0005524,GO:0005604,GO:0005652,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005911,GO:0005925,GO:0007155,GO:0010839,GO:0010839,GO:0015629,GO:0016310,GO:0016323,GO:0016363,GO:0031982,GO:0042043,GO:0042734,GO:0045944,GO:0046037,GO:0046710,GO:0046928,GO:0051649,GO:0060170,GO:0061045,GO:0070509,GO:0090280,GO:0090288,GO:0098685,GO:0106310,GO:2000300

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERBIN CASK 15123239 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
AR CASK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 CASK 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CASK 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CASK 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CASK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004DA9DB CASK 25373785 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007D64A CASK 22927820 23446348 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00000F0F49 CASK 22927820 23446348 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000040EE1D CASK 22927820 23446348 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000041CB9C CASK 22927820 23446348 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CASK 22927820 23446348 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 CASK 23446348 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000475586 CASK 22927820 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00000F6E49 CASK 22927820 25416803 27292025 27418678 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CASK CASK 22135298 phosphorylation N/A PhosphoSite
CASK NRXN1 22135298 phosphorylation N/A PhosphoSite
EPS8 CASK 25361965 interaction type N/A PTMCode2
CASK EPS8 25361965 interaction type N/A PTMCode2
SPATA2 CASK 25361965 interaction type N/A PTMCode2
CASK SPATA2 25361965 interaction type N/A PTMCode2
EPB41 CASK 25361965 interaction type N/A PTMCode2
CASK EPB41 25361965 interaction type N/A PTMCode2
SDC2 CASK 25361965 interaction type N/A PTMCode2
CASK SDC2 25361965 interaction type N/A PTMCode2
DLG4 CASK 25361965 interaction type N/A PTMCode2
CASK DLG4 25361965 interaction type N/A PTMCode2
CNTNAP2 CASK 25361965 interaction type N/A PTMCode2
CASK CNTNAP2 25361965 interaction type N/A PTMCode2
LIN7B CASK 25361965 interaction type N/A PTMCode2
CASK LIN7B 25361965 interaction type N/A PTMCode2
KIF17 CASK 25361965 interaction type N/A PTMCode2
CASK KIF17 25361965 interaction type N/A PTMCode2
SDC1 CASK 25361965 interaction type N/A PTMCode2
CASK SDC1 25361965 interaction type N/A PTMCode2
SDC3 CASK 25361965 interaction type N/A PTMCode2
CASK SDC3 25361965 interaction type N/A PTMCode2
CADM1 CASK 25361965 interaction type N/A PTMCode2
CASK CADM1 25361965 interaction type N/A PTMCode2
TSPYL2 CASK 25361965 interaction type N/A PTMCode2
CASK TSPYL2 25361965 interaction type N/A PTMCode2
NRXN2 CASK 25361965 interaction type N/A PTMCode2
CASK NRXN2 25361965 interaction type N/A PTMCode2
KCNJ4 CASK 25361965 interaction type N/A PTMCode2
CASK KCNJ4 25361965 interaction type N/A PTMCode2
SDC4 CASK 25361965 interaction type N/A PTMCode2
CASK SDC4 25361965 interaction type N/A PTMCode2
CASK NPHS1 25361965 interaction type N/A PTMCode2
NPHS1 CASK 25361965 interaction type N/A PTMCode2
CASK TBR1 25361965 interaction type N/A PTMCode2
TBR1 CASK 25361965 interaction type N/A PTMCode2
CASK FCHSD2 25361965 interaction type N/A PTMCode2
FCHSD2 CASK 25361965 interaction type N/A PTMCode2
CASK RPH3A 25361965 interaction type N/A PTMCode2
RPH3A CASK 25361965 interaction type N/A PTMCode2
CASKIN1 CASK 25361965 interaction type N/A PTMCode2
CASK CASKIN1 25361965 interaction type N/A PTMCode2
KCNJ12 CASK 25361965 interaction type N/A PTMCode2
CASK KCNJ12 25361965 interaction type N/A PTMCode2
ATP2B4 CASK 25361965 interaction type N/A PTMCode2
CASK ATP2B4 25361965 interaction type N/A PTMCode2
APBA1 CASK 25361965 interaction type N/A PTMCode2
CASK APBA1 25361965 interaction type N/A PTMCode2
KCNJ2 CASK 25361965 interaction type N/A PTMCode2
CASK KCNJ2 25361965 interaction type N/A PTMCode2
F11R CASK 25361965 interaction type N/A PTMCode2
CASK F11R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LIN7A CASK 14525934 16688213 24234451 24366813 25348397 25416956 9753324 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
SPATA2 CASK 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB3A CASK 11377421 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
DLG4 CASK 12151521 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ERBIN CASK 25348397 N/A physical interaction ComPPI
NPHS1 CASK 14525934 15331416 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TIAM1 CASK 21763699 24234451 25348397 physical association blue native page ComPPI,IntAct
RPH3A CASK 11377421 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
EP300 CASK 21988832 24234451 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SDC2 CASK 14525934 24234451 25348397 9660868 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
HGS CASK 25348397 N/A physical interaction ComPPI
NTRK1 CASK 25348397 N/A physical interaction ComPPI
DUSP3 CASK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPS8 CASK 14525934 16688213 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
KCNA4 CASK 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F11R CASK 11120739 24234451 25348397 association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,IntAct
HNRNPL CASK 25348397 N/A physical interaction ComPPI
SDC4 CASK 14525934 25348397 9660868 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
KCNJ4 CASK 11742811 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASK SDC1 14525934 25348397 9660868 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CASK SDC3 10460248 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASK ATP2B4 12511555 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASK KCNJ2 14525934 15024025 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASK DLG1 10993877 12351654 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CASK APBA1 14525934 21763699 24234451 25348397 9753324 9822620 9952408 physical association experimental interaction detection,physical interaction,blue native page,in vitro,in vivo ComPPI,HPRD,IntAct
CASK PRKN 11679592 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASK CNTNAP2 12093160 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CASK CADM1 12202822 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASK TSPYL2 14525934 15066269 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
CASK TBR1 10749215 11377421 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CASK ID1 14525934 15694377 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
CASK NRXN3 25348397 N/A two hybrid,in vitro ComPPI
CASK KCNJ12 14525934 14960569 15024025 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASK WHRN 22117215 24234451 25348397 N/A two hybrid,fluorescence polarization spectroscopy,in vivo ComPPI,IntAct
CASK LIN7B 11742811 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASK CASKIN1 12040031 14525934 21763699 24234451 25348397 association,physical association transmission electron microscopy,cosedimentation in solution,experimental interaction detection,molecular sieving,surface plasmon resonance,physical interaction,blue native page,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
CASK NRXN2 14525934 25348397 8786425 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CASK CNTNAP4 12093160 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CASK FCHSD2 14525934 14627983 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASK GRIN2A 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASK GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASK KCNJ18 25348397 N/A physical interaction ComPPI
CASK LIN7C 25348397 N/A physical interaction ComPPI
CASK EPB41 24234451 25348397 9660868 N/A far western blotting,physical interaction ComPPI,IntAct
CASK UIMC1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASK ELAVL1 25348397 N/A physical interaction ComPPI
CASK ARIH1 25348397 N/A physical interaction ComPPI
CASK PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASK IL15RA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK WNT7B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK CDK9 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK PPP4R3A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK IL18 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK MARS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK MLLT6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK P2RX7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK PCBP2 25348397 N/A physical interaction ComPPI
CASK PCM1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK GCNT3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK TRIM22 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK ELL2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK BNIP3L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASK SRPK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CASK PTGS2 25348397 N/A physical interaction ComPPI
CASK NEDD1 25348397 N/A physical interaction ComPPI
CASK SH2D4A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CASK FOXRED2 25348397 N/A physical interaction ComPPI
CASK ABLIM1 25348397 N/A physical interaction ComPPI
CASK DTNB 25348397 N/A physical interaction ComPPI
CASK EEF2 25348397 N/A physical interaction ComPPI
CASK ARHGEF26 25348397 N/A physical interaction ComPPI
CASK SNTB2 24234451 25348397 25852190 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASK MYBPHL 25348397 N/A physical interaction ComPPI
CASK PPM1B 25348397 N/A physical interaction ComPPI
CASK CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CASK TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CASK SLC16A6 25348397 N/A physical interaction ComPPI
CASK KIF26B 25348397 N/A physical interaction ComPPI
CASK DUSP10 25348397 N/A physical interaction ComPPI
CASK ZNF414 25348397 N/A physical interaction ComPPI
CASK PTPDC1 25348397 N/A physical interaction ComPPI
CASK ZNF785 25348397 N/A physical interaction ComPPI
CASK MYCL 25348397 N/A physical interaction ComPPI
CASK KLHL2 25348397 N/A physical interaction ComPPI
CASK FRMD7 25348397 N/A physical interaction ComPPI
CASK ARHGEF7 15975580 24234451 25348397 physical association pull down ComPPI,IntAct
CASK TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
CASK TUBA1A 24234451 25348397 27291054 association pull down ComPPI,IntAct
CASK KIRREL3 19012874 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CASK EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CASK LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CASK TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLK2 CASK 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM26 CASK 25348397 N/A physical interaction ComPPI
CASK CI 15710747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
CASK CASK 12040031 12093160 12641734 14525934 15024025 9660869 9822620 9952408 N/A experimental interaction detection,two hybrid HPRD
NRXN1 CASK 11036064 14525934 8786425 N/A experimental interaction detection,two hybrid HPRD
TANC1 CASK 14525934 15673434 N/A experimental interaction detection HPRD
CASK GRIK2 12151522 14525934 N/A experimental interaction detection HPRD
CASK DNAJC5 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct
CASK SDC2 12676536 27898060 9660868 N/A N/A OmniPath
CASK SDC1 27898060 9660868 N/A N/A OmniPath
ERBIN CASK 15123239 27898060 N/A N/A OmniPath
CASK F11R 10856295 11120739 27898060 N/A N/A OmniPath
CASK SDC3 10460248 27898060 9660868 N/A N/A OmniPath
CASK CNTNAP2 12093160 27898060 N/A N/A OmniPath
CASK CNTNAP4 12093160 27898060 N/A N/A OmniPath
CASK SDC4 27898060 9660868 N/A N/A OmniPath
CASK NRXN1 11036064 18423203 27898060 8786425 N/A N/A OmniPath

Visualization










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