Gene Information gene info

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GENE：ATF3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATF3
FullNmae activating transcription factor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:785
EnsembleID ENSG00000162772
Uniprot P18847

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATF3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATF3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATF3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATF3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATF3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATF3 GO:0000122,GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001228,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006094,GO:0006357,GO:0006357,GO:0006357,GO:0008284,GO:0010628,GO:0030968,GO:0034198,GO:0035914,GO:0042802,GO:0042803,GO:0045944,GO:0045944,GO:0045944,GO:0046982,GO:0070373,GO:0090575,GO:1903984,GO:1990440,GO:1990622,GO:1990837

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD4 ATF3 11074002 11170475 11279127 11792802 12490555 12702545 12718878 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 23850759 26192618 8893010 9389648 9865696 interaction type N/A ACSN
ATF3 ATF4 23850759 26192618 26587781 interaction type N/A ACSN
NFKB1 ATF3 23180781 7692236 physical association gst pull down InnateDB
MMP1 ATF3 18802113 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELAVL1 ATF3 16109718 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB
HNRNPD ATF3 16109718 23180781 physical association anti tag coimmunoprecipitation InnateDB
ASNS ATF3 18840095 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATF3 SLC11A1 21300803 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ATF3 SMARCA4 21300803 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATF3 ACTB 21300803 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMARCA4 ATF3 21300803 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ATF3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ATF2 ATF3 10979959 20581861 8576171 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
EGR1 ATF3 16489044 18971253 21205742 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 ATF3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ATF3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ATF3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 ATF3 12372430 18971253 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TP73 ATF3 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 ATF3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ATF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 ATF3 16246168 21801305 22819556 trascriptional regulation,stimulation inferred by curator TFlink
JDP2 ATF3 19233874 22989952 trascriptional regulation,stimulation inferred by curator TFlink
JUN ATF3 8576171 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 ATF3 21205742 trascriptional regulation,stimulation inferred by curator TFlink
KLF6 ATF3 18755691 trascriptional regulation,stimulation inferred by curator TFlink
MEF2D ATF3 17108111 trascriptional regulation,stimulation inferred by curator TFlink
MYC ATF3 21384303 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 ATF3 24100018 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 ATF3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 ATF3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001597DC ATF3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA ATF3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000535FDD ATF3 23160513 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000017EA6A ATF3 23787480 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,immunohistochemistry TarBase
URS00001DE669 ATF3 23787480 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,immunohistochemistry TarBase
URS0000065D58 ATF3 23787480 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,immunohistochemistry TarBase
URS000075D814 ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 ATF3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 ATF3 25150595 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000137EDE ATF3 25416803 26418018 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ATF2 ATF3 25361965 interaction type N/A PTMCode2
ATF3 ATF2 25361965 interaction type N/A PTMCode2
JUND ATF3 25361965 interaction type N/A PTMCode2
ATF3 JUND 25361965 interaction type N/A PTMCode2
JUNB ATF3 25361965 interaction type N/A PTMCode2
ATF3 JUNB 25361965 interaction type N/A PTMCode2
TP53 ATF3 25361965 interaction type N/A PTMCode2
ATF3 TP53 25361965 interaction type N/A PTMCode2
ATF3 JUN 25361965 interaction type N/A PTMCode2
JUN ATF3 25361965 interaction type N/A PTMCode2
ATF4 ATF3 25361965 interaction type N/A PTMCode2
ATF3 ATF4 25361965 interaction type N/A PTMCode2
NFKB1 ATF3 25361965 interaction type N/A PTMCode2
ATF3 NFKB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I ATF3 25348397 N/A physical interaction ComPPI
ATF4 ATF3 19164757 20102225 23661758 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,peptide array,physical interaction,electrophoretic mobility shift assay ComPPI,IntAct,OmniPath
CEBPG ATF3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
STAT1 ATF3 19647793 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TP53BP1 ATF3 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
ACTB ATF3 25348397 N/A physical interaction ComPPI
JUNB ATF3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
BATF ATF3 25348397 N/A physical interaction ComPPI
HSP90AB1 ATF3 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CRK ATF3 25348397 N/A two hybrid,physical interaction ComPPI
ZNF212 ATF3 18255255 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NFATC1 ATF3 24234451 25348397 25609649 association,physical association physical interaction,tandem affinity purification ComPPI,IntAct
JUN ATF3 10327051 14525934 14667575 20102225 24234451 25348397 25609649 8649793 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,peptide array,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CREBBP ATF3 19932681 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD2 ATF3 25348397 N/A physical interaction ComPPI
FOSL2 ATF3 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
SMAD3 ATF3 12718878 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ATF3 JUND 14525934 20102225 24234451 25348397 27898060 8152431 N/A experimental interaction detection,peptide array,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
ATF3 FGFR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATF3 NUF2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATF3 IGSF21 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ATF3 LRIF1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ATF3 DDIT3 14525934 20102225 24234451 25348397 27107012 29997244 8622660 physical association bioluminescence resonance energy transfer,experimental interaction detection,peptide array,physical interaction,in vitro,in vivo,luminescence based mammalian interactome mapping,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
ATF3 NFKB1 14525934 25348397 7692236 N/A experimental interaction detection,in vitro ComPPI,HPRD
ATF3 TP53 11792711 14525934 16169070 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,HPRD,IntAct
ATF3 MDM2 15933712 20592017 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATF3 POLR3D 25348397 N/A physical interaction ComPPI
ATF3 SS18L1 25348397 N/A physical interaction ComPPI
ATF3 SMARCA4 25348397 N/A physical interaction ComPPI
ATF3 RELA 25348397 N/A physical interaction ComPPI
ATF3 CEBPE 25348397 N/A physical interaction ComPPI
ATF3 HDAC1 20360311 22989952 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATF3 CEBPB 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
ATF3 GSK3B 25348397 N/A physical interaction ComPPI
ATF3 PDX1 21986529 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ATF3 HDAC6 25348397 N/A physical interaction ComPPI
ATF3 HDAC10 25348397 N/A physical interaction ComPPI
ATF3 HDAC4 25348397 N/A physical interaction ComPPI
ATF3 HDAC5 25348397 N/A physical interaction ComPPI
ATF3 HDAC3 25348397 N/A physical interaction ComPPI
ATF3 FHL2 18255255 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
ATF3 SRA1 25348397 N/A physical interaction ComPPI
ATF3 HSP90AA1 25348397 N/A physical interaction ComPPI
ATF3 HSP90AA2P 25348397 N/A physical interaction ComPPI
ATF3 MAFG 25348397 N/A physical interaction ComPPI
ATF3 MAFF 25348397 N/A physical interaction ComPPI
ATF3 FOSL1 25348397 N/A physical interaction ComPPI
ATF3 FOS 25348397 N/A physical interaction ComPPI
ATF3 CEBPA 25348397 N/A physical interaction ComPPI
ATF3 DBP 25348397 N/A physical interaction ComPPI
ATF3 CREB3 25348397 N/A physical interaction ComPPI
ATF3 SUV39H1 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATF3 SH2D1A 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
ATF3 APPL2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATF3 DOK5 25348397 N/A physical interaction ComPPI
ATF3 STAT3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATF3 EWSR1 25348397 N/A physical interaction ComPPI
ATF3 MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ATF3 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ATF3 KAT5 25348397 N/A physical interaction ComPPI
ATF3 DNMT3L 25348397 N/A physical interaction ComPPI
ATF3 TRIM25 25348397 N/A physical interaction ComPPI
ATF3 TP63 25348397 N/A physical interaction ComPPI
ATF3 TP73 25348397 N/A physical interaction ComPPI
ATF3 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ATF3 ATF7 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
ATF3 MAFB 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
ID3 ATF3 18255255 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATF2 ATF3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
BATF3 ATF3 12805554 14525934 20102225 24234451 25348397 N/A experimental interaction detection,peptide array,physical interaction,in vitro ComPPI,HPRD,IntAct
JRA ATF3 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SGG ATF3 25348397 N/A two hybrid ComPPI
ATF3 ATF3 14525934 18255255 24234451 8152431 physical association two hybrid,experimental interaction detection,pull down HPRD,IntAct
ATF3 NFKB1 27898060 7692236 N/A N/A OmniPath
ATF2 ATF3 12833146 20102225 20211142 23661758 27898060 stimulant N/A OmniPath
TP53 ATF3 11792711 15933712 16169070 18431400 27898060 stimulant N/A OmniPath
ATF3 TP53 11792711 15933712 16169070 18431400 27898060 inhibition N/A OmniPath
ATF3 CGA 15961508 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009ADCF7 ATF3 27087310 direct interaction,inhibition N/A NPInter

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