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GENE：E2F4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol E2F4
FullNmae E2F transcription factor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3118
EnsembleID ENSG00000205250
Uniprot Q16254

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
E2F4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
E2F4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
E2F4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
E2F4 GO:0000083,GO:0000785,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001216,GO:0001228,GO:0002064,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0006357,GO:0006884,GO:0008015,GO:0009887,GO:0019904,GO:0042127,GO:0044458,GO:0045944,GO:0045944,GO:0046983,GO:0090575,GO:0098534,GO:1903251,GO:1990837,GO:1990841

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
E2F4 hsa:1874 path:hsa04110 Cell cycle - Homo sapiens (human)
E2F4 hsa:1874 path:hsa04218 Cellular senescence - Homo sapiens (human)
E2F4 hsa:1874 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EP300 E2F4 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 BRCA1 16357170 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 E2F1 16357170 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 DIRAS3 16638845 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
E2F4 DRAM1 18408756 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 ULK1 18408756 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 BECN1 11564866 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 SNX19 11564866 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 SUZ12 11564866 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 PA2G4 21085677 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 E2F4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 E2F4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF E2F4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 E2F4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HCFC1 E2F4 17612494 trascriptional regulation,stimulation inferred by curator TFlink
RBL2 E2F4 8575214 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 E2F4 23060449 trascriptional regulation,stimulation inferred by curator TFlink
TP53 E2F4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 E2F4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED E2F4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 E2F4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000122ED0 E2F4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007F792 E2F4 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F9738 E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDA4 E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C E2F4 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 E2F4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 E2F4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHMP2A E2F4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GMNN E2F4 25348397 N/A physical interaction ComPPI
LIN37 E2F4 17531812 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RYBP E2F4 25348397 N/A physical interaction ComPPI
ARID3A E2F4 14525934 15017387 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RB1 E2F4 14525934 16360038 24234451 25348397 8657117 physical association coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
HCFC1 E2F4 25348397 N/A physical interaction ComPPI
AR E2F4 25348397 N/A physical interaction ComPPI
SMAD2 E2F4 12150994 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD3 E2F4 12150994 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SPIB E2F4 25348397 N/A physical interaction ComPPI
HDAC3 E2F4 25348397 N/A physical interaction ComPPI
FHL2 E2F4 25348397 N/A physical interaction ComPPI
MYBL2 E2F4 17159899 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NCOR2 E2F4 25348397 N/A physical interaction ComPPI
ENO1 E2F4 25348397 N/A physical interaction ComPPI
RBL2 E2F4 11573202 14525934 17159899 17531812 20133863 22002537 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SIN3A E2F4 25348397 N/A physical interaction ComPPI
POMC E2F4 25348397 N/A physical interaction ComPPI
ASH2L E2F4 25348397 N/A physical interaction ComPPI
XPO1 E2F4 12860972 22833565 25348397 27898060 N/A physical interaction ComPPI,OmniPath
E2F4 TFDP1 10540350 14525934 16360038 24234451 25348397 27705803 association,physical association experimental interaction detection,isothermal titration calorimetry,physical interaction,two hybrid array,in vitro,tandem affinity purification,two hybrid prey pooling approach ComPPI,HPRD,IntAct
E2F4 NDN 12198120 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
E2F4 TFDP2 10090723 14525934 16360038 24234451 25348397 physical association experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
E2F4 TRRAP 11418595 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
E2F4 BRCA1 14525934 25348397 9244350 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
E2F4 RBL1 11573202 12150994 14525934 16360038 24234451 25348397 8643455 physical association coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
E2F4 NOLC1 25348397 N/A in vitro,in vivo ComPPI
E2F4 MGA 25348397 N/A physical interaction ComPPI
E2F4 HDAC1 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
E2F4 CCNE1 25348397 N/A physical interaction ComPPI
E2F4 RNF144A 25348397 N/A physical interaction ComPPI
E2F4 KMT2A 25348397 N/A physical interaction ComPPI
E2F4 ID2 25348397 N/A physical interaction ComPPI
E2F4 KAT2A 25348397 N/A physical interaction ComPPI
E2F4 ATAD2 25348397 N/A physical interaction ComPPI
E2F4 LIN54 17531812 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F4 LIN9 17159899 17531812 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F4 CEBPA 25348397 N/A physical interaction ComPPI
E2F4 TRIM28 25348397 N/A physical interaction ComPPI
E2F4 PCM1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
E2F4 AP3S2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
E2F4 POLR1D 25348397 N/A physical interaction ComPPI
E2F4 POLR1D 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
E2F4 MOV10 25348397 N/A physical interaction ComPPI
E2F4 NXF1 25348397 N/A physical interaction ComPPI
E2F4 PML 22002537 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F4 CDK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F4 CCDC183 25348397 N/A physical interaction ComPPI
E2F4 TFDP3 25348397 N/A physical interaction ComPPI
E2F4 DNMT3L 25348397 N/A physical interaction ComPPI
E2F4 EGFR 25348397 N/A physical interaction ComPPI
E2F4 CDK4 24234451 25348397 27173435 physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
E2F4 L3MBTL3 17517653 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F4 KAT5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
E2F4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
E2F4 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
ID3 E2F4 25348397 N/A physical interaction ComPPI
CEBPB E2F4 16959612 27898060 stimulant N/A OmniPath
MAPK3 E2F4 23919615 27898060 N/A N/A OmniPath
E2F4 CDK1 15510213 27898060 inhibition N/A OmniPath
E2F4 CCNB1 15510213 27898060 inhibition N/A OmniPath
E2F4 MYBL2 17159899 27898060 8334989 inhibition N/A OmniPath
RBL2 E2F4 11573202 12006580 15838517 16600870 17159899 17531812 17671431 22002537 23108140 27898060 8657117 9144196 9858615 stimulant N/A OmniPath
E2F4 CLSPN 17251008 18319725 27898060 inhibition N/A OmniPath
RBL1 E2F4 11573202 12150994 15838517 17671431 27898060 7958924 7958925 8643455 8657117 8832394 9144196 9501179 9724731 9858615 stimulant N/A OmniPath
E2F4 CDT1 14990995 18319725 27898060 inhibition,stimulant N/A OmniPath

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