Gene Information gene info

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GENE：DFFB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DFFB
FullNmae DNA fragmentation factor subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2773
EnsembleID ENSG00000169598
Uniprot O76075

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DFFB necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DFFB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DFFB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DFFB apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DFFB GO:0000785,GO:0003677,GO:0004520,GO:0004536,GO:0004536,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005829,GO:0005829,GO:0006308,GO:0006309,GO:0006309,GO:0019899,GO:0019904,GO:0030263,GO:0032991,GO:0042802,GO:0097718,GO:1902511

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DFFB hsa:1677 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP DFFB 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
CIDEB DFFB 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 DFFB 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF DFFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DFFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DFFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DFFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DFFB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 DFFB 14559996 trascriptional regulation,stimulation inferred by curator TFlink
MYC DFFB 10931841 17706770 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 DFFB 14559996 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 DFFB N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 DFFB N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 DFFB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004505E4 DFFB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000355E82 DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000458AD2 DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 DFFB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000486E0B DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021202F DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CCD18 DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA DFFB 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 DFFB 25348397 N/A physical interaction ComPPI
BMI1 DFFB 20601937 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PRKACB DFFB 25348397 N/A physical interaction ComPPI
COPS5 DFFB 25348397 N/A physical interaction ComPPI
PKN2 DFFB 25348397 N/A physical interaction ComPPI
UBB DFFB 25348397 N/A physical interaction ComPPI
PARP2 DFFB 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
HNRNPL DFFB 25348397 N/A physical interaction ComPPI
MARCKS DFFB 25348397 N/A physical interaction ComPPI
NEDD8 DFFB 25348397 N/A physical interaction ComPPI
CUL2 DFFB 25348397 N/A physical interaction ComPPI
CUL1 DFFB 25348397 N/A physical interaction ComPPI
H1-5 DFFB 19882353 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PTPN13 DFFB 25348397 N/A physical interaction ComPPI
CAND1 DFFB 25348397 N/A physical interaction ComPPI
NUBP1 DFFB 25348397 N/A physical interaction ComPPI
DFFA DFFB 10409614 10527860 10527861 10932250 11371636 14525934 17353931 19882353 24234451 25348397 9108473 9422506 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,filter binding,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
DFFB CIDEB 10619428 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DFFB TOP2A 10959840 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
DFFB LTB4R2 25348397 N/A physical interaction ComPPI
DFFB APP 25348397 N/A physical interaction ComPPI
DFFB MAGOH 25348397 N/A physical interaction ComPPI
DFFB LRRC15 25348397 N/A physical interaction ComPPI
DFFB NEFH 25348397 N/A physical interaction ComPPI
DFFB H1-1 19882353 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DFFB H1-0 19882353 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DFFB H1-3 19882353 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DFFB LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
DFFB DFFB 14525934 15149602 N/A experimental interaction detection HPRD
VIM DFFB 24234451 30021884 physical association cross-linking study IntAct
DFFA DFFB 10409614 10527860 10527861 10932250 11371636 12655299 15572351 17353931 19882353 26186194 27898060 9108473 9422506 9422513 inhibition N/A OmniPath
CASP3 DFFB 27898060 9108473 stimulant N/A OmniPath

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