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GENE：ERCC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERCC4
FullNmae ERCC excision repair 4, endonuclease catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3436
EnsembleID ENSG00000175595
Uniprot Q92889

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERCC4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC4 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ERCC4 GO:0000014,GO:0000109,GO:0000110,GO:0000110,GO:0000712,GO:0000723,GO:0000723,GO:0000724,GO:0000724,GO:0000781,GO:0001094,GO:0003677,GO:0003684,GO:0003684,GO:0003697,GO:0003697,GO:0004520,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006281,GO:0006289,GO:0006289,GO:0006303,GO:0009411,GO:0009650,GO:0010506,GO:0032205,GO:0034644,GO:0034644,GO:0042802,GO:0061819,GO:0070522,GO:0070522,GO:1901255,GO:1901255,GO:1904357,GO:1905765,GO:1905768,GO:1990599,GO:1990841

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERCC4 hsa:2072 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
ERCC4 hsa:2072 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ERCC4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ERCC4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ERCC4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ERCC4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERCC4 18971253 20976523 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ERCC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 ERCC4 21672525 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 ERCC4 19074876 21672525 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 ERCC4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B ERCC4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 ERCC4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ERCC4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 ERCC4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 ERCC4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 ERCC4 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FEN1 ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 FEN1 25361965 interaction type N/A PTMCode2
RPA1 ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 RPA1 25361965 interaction type N/A PTMCode2
ERCC1 ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 ERCC1 25361965 interaction type N/A PTMCode2
MSH2 ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 MSH2 25361965 interaction type N/A PTMCode2
ERCC4 RAD52 25361965 interaction type N/A PTMCode2
RAD52 ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 XPA 25361965 interaction type N/A PTMCode2
XPA ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 PCNA 25361965 interaction type N/A PTMCode2
PCNA ERCC4 25361965 interaction type N/A PTMCode2
ERCC4 FANCA 25361965 interaction type N/A PTMCode2
FANCA ERCC4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TP53BP1 ERCC4 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
EGLN3 ERCC4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
GTF2H1 ERCC4 11259578 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NTRK1 ERCC4 25348397 N/A physical interaction ComPPI
PLK1 ERCC4 19596235 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTAN1 ERCC4 11401546 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2B ERCC4 25348397 N/A physical interaction ComPPI
FANCD2 ERCC4 25348397 N/A physical interaction ComPPI
XPA ERCC4 25348397 N/A physical interaction ComPPI
RNF8 ERCC4 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
SUMO2 ERCC4 25348397 N/A physical interaction ComPPI
NEDD8 ERCC4 18274552 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SPTA1 ERCC4 25348397 N/A physical interaction ComPPI
EGFR ERCC4 24234451 24780295 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
XPC ERCC4 19279666 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
POLR2A ERCC4 25348397 N/A physical interaction ComPPI
MDC1 ERCC4 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
GYPB ERCC4 25348397 N/A physical interaction ComPPI
BRCA1 ERCC4 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
TADA2A ERCC4 25348397 N/A physical interaction ComPPI
ALYREF ERCC4 25348397 N/A physical interaction ComPPI
UHRF1 ERCC4 25348397 N/A physical interaction ComPPI
MUS81 ERCC4 25348397 N/A physical interaction ComPPI
EME1 ERCC4 17289582 24234451 25348397 physical association pull down ComPPI,IntAct
ERCC4 ERCC1 14525934 16338413 17289582 24234451 24780295 25348397 8197175 9722633 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ERCC4 SLX4 14525934 19596235 19596236 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
ERCC4 FANCA 25348397 N/A physical interaction ComPPI
ERCC4 SLX4IP 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC4 SLX1A 19596235 19596236 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC4 FANCG 25348397 N/A physical interaction ComPPI
ERCC4 ERCC6 25348397 N/A physical interaction ComPPI
ERCC4 ERCC6 25348397 N/A physical interaction ComPPI
ERCC4 VPS26A 25348397 N/A physical interaction ComPPI
ERCC4 MSH2 25348397 N/A physical interaction ComPPI
ERCC4 C10ORF55 25348397 N/A physical interaction ComPPI
ERCC4 USP45 25348397 N/A physical interaction ComPPI
ERCC4 NFKBID 25348397 N/A physical interaction ComPPI
ERCC4 ZFC3H1 25348397 N/A physical interaction ComPPI
ERCC4 DCAF1 24234451 24412650 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
LYAR ERCC4 25348397 N/A physical interaction ComPPI
ERCC4 ERCC4 22483113 24234451 N/A mass spectrometry studies of complexes,nuclear magnetic resonance IntAct
HSPD1 ERCC4 24234451 30021884 physical association cross-linking study IntAct
RAD52 ERCC4 14734547 27898060 N/A N/A OmniPath
SLX4 ERCC4 19595721 19595722 19596235 19596236 21240275 22902628 23093618 23994477 24012755 24726326 25538220 27898060 stimulant N/A OmniPath
XPA ERCC4 17948053 27898060 stimulant N/A OmniPath

Visualization










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