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GENE：LRP8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRP8
FullNmae LDL receptor related protein 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6700
EnsembleID ENSG00000157193
Uniprot Q14114

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRP8 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LRP8 GO:0001523,GO:0001540,GO:0004888,GO:0005041,GO:0005509,GO:0005515,GO:0005615,GO:0005875,GO:0005886,GO:0005886,GO:0005901,GO:0005901,GO:0006508,GO:0006629,GO:0006897,GO:0007165,GO:0007268,GO:0008035,GO:0009410,GO:0009986,GO:0016020,GO:0016020,GO:0019221,GO:0019894,GO:0021517,GO:0021541,GO:0021819,GO:0030229,GO:0030424,GO:0030425,GO:0032793,GO:0034185,GO:0038024,GO:0038025,GO:0038026,GO:0042981,GO:0043025,GO:0043235,GO:0045088,GO:0045202,GO:0048306,GO:0048813,GO:0050731,GO:0050804,GO:0061003,GO:0061098,GO:0071363,GO:0071397,GO:1900006

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR LRP8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LRP8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LRP8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LRP8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 LRP8 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 LRP8 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LRP8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIC1 LRP8 24076391 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 LRP8 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 LRP8 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A LRP8 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB LRP8 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000F31F4 LRP8 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 LRP8 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00002152A8 LRP8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007F792 LRP8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB LRP8 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB LRP8 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 LRP8 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 LRP8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 LRP8 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DLG4 LRP8 25361965 interaction type N/A PTMCode2
LRP8 DLG4 25361965 interaction type N/A PTMCode2
APOE LRP8 25361965 interaction type N/A PTMCode2
LRP8 APOE 25361965 interaction type N/A PTMCode2
SNX17 LRP8 25361965 interaction type N/A PTMCode2
LRP8 SNX17 25361965 interaction type N/A PTMCode2
MAPK8IP1 LRP8 25361965 interaction type N/A PTMCode2
LRP8 MAPK8IP1 25361965 interaction type N/A PTMCode2
LRP8 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 LRP8 25361965 interaction type N/A PTMCode2
LRP8 DAB1 25361965 interaction type N/A PTMCode2
DAB1 LRP8 25361965 interaction type N/A PTMCode2
LRP8 RELN 25361965 interaction type N/A PTMCode2
RELN LRP8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TYK2 LRP8 25348397 N/A physical interaction ComPPI
PPP1R9A LRP8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DLG4 LRP8 14525934 16332682 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CLU LRP8 25348397 N/A in vitro,in vivo ComPPI
DAB1 LRP8 10380922 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
APC LRP8 19116273 24234451 25348397 N/A surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,surface plasmon resonance array ComPPI,IntAct
SNX17 LRP8 12169628 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PRKRIP1 LRP8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APOE LRP8 12167620 12950167 14525934 24234451 25348397 physical association affinity chromatography technology,experimental interaction detection,physical interaction,affinity technology,in vivo ComPPI,HPRD,IntAct
LRP8 RELN 10571240 12167620 12670700 12899622 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LRP8 GRIN1 14525934 16332682 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LRP8 APOH 12807892 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
LRP8 LRPAP1 12899622 14525934 20223215 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
LRP8 GIPC1 25348397 N/A physical interaction ComPPI
LRP8 MAPK8IP1 25348397 N/A physical interaction ComPPI
LRP8 MAPK8IP2 25348397 N/A physical interaction ComPPI
LRP8 NOS1AP 25348397 N/A physical interaction ComPPI
LRP8 SCN3A 25348397 N/A physical interaction ComPPI
LRP8 APBA2 25348397 N/A physical interaction ComPPI
LRP8 ANAPC10 25348397 N/A physical interaction ComPPI
LRP8 MYLIP 25348397 N/A physical interaction ComPPI
LRP8 MOV10 25348397 N/A physical interaction ComPPI
LRP8 NXF1 25348397 N/A physical interaction ComPPI
LRP8 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LRP8 ALB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 PRCC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 RAD51 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 USP11 25348397 N/A physical interaction ComPPI
LRP8 DOCK6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 CAMSAP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 CRTC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 ARHGAP39 25348397 N/A physical interaction ComPPI
LRP8 GHDC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 ANGEL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP8 C19ORF47 25348397 N/A physical interaction ComPPI
LRP8 EGFR 25348397 N/A physical interaction ComPPI
LRP8 TRIM25 25348397 N/A physical interaction ComPPI
LRP8 HNRNPL 25348397 N/A physical interaction ComPPI
LRP8 SS18 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
LRP8 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ITGB1BP1 LRP8 25348397 N/A physical interaction ComPPI
SYNJ2BP LRP8 25348397 N/A physical interaction ComPPI
LRP8 KDR 24234451 30139844 physical association anti bait coimmunoprecipitation,proximity ligation assay IntAct
KRT8 LRP8 24234451 30021884 physical association cross-linking study IntAct

Visualization










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