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GENE：NEK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NEK2
FullNmae NIMA related kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7745
EnsembleID ENSG00000117650
Uniprot P51955

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NEK2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NEK2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NEK2 GO:0000278,GO:0000776,GO:0000794,GO:0000922,GO:0001824,GO:0004672,GO:0004672,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0006468,GO:0007059,GO:0007059,GO:0007088,GO:0019903,GO:0030496,GO:0032212,GO:0032991,GO:0046602,GO:0046602,GO:0046777,GO:0046777,GO:0046872,GO:0051225,GO:0051299,GO:0051301,GO:0051321,GO:0051973,GO:0051988,GO:0090307,GO:0106310,GO:1903126,GO:1904355

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTNNB1 NEK2 18086858 23180781 physical association anti tag coimmunoprecipitation InnateDB
NEK2 NEK2 18086858 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAPK1 NEK2 15358203 23180781 physical association pull down InnateDB
RHOB NEK2 19637314 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 NEK2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NEK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NEK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NEK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NEK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NEK2 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 NEK2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 NEK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000065FDF NEK2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STK3 NEK2 22135298 phosphorylation N/A PhosphoSite
NEK2 CNTROB 22135298 phosphorylation N/A PhosphoSite
NEK2 NEK2 22135298 phosphorylation N/A PhosphoSite
NEK2 PPP1CC 22135298 phosphorylation N/A PhosphoSite
NEK2 DVL3 22135298 phosphorylation N/A PhosphoSite
NEK2 CEP250 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
NEK2 NPM1 22135298 phosphorylation N/A PhosphoSite
NEK2 SGO1 22135298 phosphorylation N/A PhosphoSite
NEK2 FANCA 22135298 phosphorylation N/A PhosphoSite
NEK2 NDC80 22135298 phosphorylation N/A PhosphoSite
NEK2 CDC26 25361965 interaction type N/A PTMCode2
CDC26 NEK2 25361965 interaction type N/A PTMCode2
NEK2 NEK11 25361965 interaction type N/A PTMCode2
NEK11 NEK2 25361965 interaction type N/A PTMCode2
NEK2 MAD1L1 25361965 interaction type N/A PTMCode2
MAD1L1 NEK2 25361965 interaction type N/A PTMCode2
CEP250 NEK2 25361965 interaction type N/A PTMCode2
RHOA NEK2 25361965 interaction type N/A PTMCode2
NEK2 RHOA 25361965 interaction type N/A PTMCode2
PPP1CA NEK2 25361965 interaction type N/A PTMCode2
NEK2 PPP1CA 25361965 interaction type N/A PTMCode2
CDC16 NEK2 25361965 interaction type N/A PTMCode2
NEK2 CDC16 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PDE4DIP NEK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TCF25 NEK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NDC80 NEK2 12386167 14525934 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
PPP1CC NEK2 25348397 N/A two hybrid,physical interaction ComPPI
BFSP2 NEK2 25348397 N/A physical interaction ComPPI
VCP NEK2 25348397 N/A physical interaction ComPPI
PPP1R2B NEK2 25348397 N/A physical interaction ComPPI
MAPK1 NEK2 14525934 15358203 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDC16 NEK2 20360068 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
FZR1 NEK2 25348397 N/A physical interaction ComPPI
RHOB NEK2 19637314 24234451 25348397 physical association two hybrid ComPPI,IntAct
GIT1 NEK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1CA NEK2 10880350 12221103 14525934 22321011 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
DCTN1 NEK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 PPP1R2 12221103 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NEK2 CEP250 14525934 25348397 9647649 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NEK2 MAD1L1 14525934 14978040 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
NEK2 NEK11 14525934 15161910 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
NEK2 CLEC4C 25348397 N/A physical interaction ComPPI
NEK2 IMMT 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 TPM3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 EIF4A2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 MCC 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 IFT140 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 CCDC85A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 EDRF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 SPTBN4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 CHGA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEK2 CDC27 16648845 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK2 CHEK1 25348397 N/A physical interaction ComPPI
NEK2 CDC20 25348397 N/A physical interaction ComPPI
NEK2 CTNNB1 25348397 N/A physical interaction ComPPI
NEK2 ANAPC4 23288039 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK2 ODF2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NEK2 CDC23 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK2 ANAPC15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK2 CFAP97 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK2 MAD2L1 25348397 N/A physical interaction ComPPI
NEK2 BUB1B 25348397 N/A physical interaction ComPPI
NEK2 PRKN 25348397 N/A physical interaction ComPPI
NEK2 SMURF1 25348397 N/A physical interaction ComPPI
NEK2 C16ORF87 25348397 N/A physical interaction ComPPI
NEK2 DTD1 25348397 N/A physical interaction ComPPI
NEK2 DPP9 25348397 N/A physical interaction ComPPI
NEK2 FANCA 25348397 N/A physical interaction ComPPI
NEK2 RITA1 21102556 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
NEK2 ANAPC1 23288039 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NEK2 ANAPC7 23288039 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NEK2 KIF24 24234451 25348397 26290419 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy,protein kinase assay ComPPI,IntAct
NEK2 PTPRD 22305495 24234451 25348397 N/A protein array ComPPI,IntAct
CSN2 NEK2 25348397 N/A physical interaction ComPPI
CDC26 NEK2 20360068 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NEK2 NEK2 10347187 14525934 23288039 24234451 association anti tag coimmunoprecipitation,experimental interaction detection,two hybrid HPRD,IntAct
TANK NEK2 24234451 30561431 association virotrap IntAct
FUNDC2 NEK2 24234451 30021884 physical association cross-linking study IntAct
NEK2 CTNNB1 18086858 24501426 27898060 stimulant N/A OmniPath
NEK2 NEK11 15161910 27898060 stimulant N/A OmniPath
NEK2 SGO1 17621308 18669648 27898060 stimulant N/A OmniPath
NEK2 FANCA 23806870 27898060 N/A N/A OmniPath
NEK2 NDC80 12386167 19228686 21832156 21900206 27898060 9295362 stimulant N/A OmniPath
NEK2 ITGB2 11700305 12682249 27898060 N/A N/A OmniPath
STK3 NEK2 17197699 21076410 27898060 stimulant N/A OmniPath
NEK2 NPM1 16944950 23851489 24616519 27898060 N/A N/A OmniPath
PPP1CA NEK2 10880350 12221103 17283141 22321011 27898060 inhibition N/A OmniPath
NEK2 CEP250 12140259 21076410 21723128 23443559 24695856 25660448 27898060 9647649 inhibition,stimulant N/A OmniPath
MAPK1 NEK2 15358203 27898060 N/A N/A OmniPath
NEK2 CNTROB 17535851 23291182 27898060 stimulant N/A OmniPath
NEK2 PPP1CC 10880350 21382349 23080069 24902662 27898060 inhibition N/A OmniPath
PCM1 NEK2 15659651 27898060 stimulant N/A OmniPath
NEK2 SCAMP3 27898060 9658162 N/A N/A OmniPath

Visualization










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