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GENE：BCL2A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCL2A1
FullNmae BCL2 related protein A1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:991
EnsembleID ENSG00000140379
Uniprot Q16548

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCL2A1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2A1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2A1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2A1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2A1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BCL2A1 GO:0001836,GO:0005515,GO:0005737,GO:0005741,GO:0005829,GO:0008053,GO:0008630,GO:0015267,GO:0042803,GO:0043065,GO:0043066,GO:0046982,GO:0055085,GO:0097192

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCL2A1 hsa:597 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
BCL2A1 hsa:597 path:hsa04210 Apoptosis - Homo sapiens (human)
BCL2A1 hsa:597 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
BCL2A1 hsa:597 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BBC3 BCL2A1 11463391 11463392 23430059 26192618 association N/A ACSN
BCL2L11 BCL2A1 23430059 23850759 26192618 association N/A ACSN
NFKB1 BCL2A1 10049356 21725609 23178297 23572150 26192618 interaction type N/A ACSN
BCL2A1 REL 12665576 17567982 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 CD40 17567982 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 BAX 14766748 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 JUN 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 CEBPB 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 HMGA2 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 TAF1 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 BCL2A1 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 SMARCA4 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 TBP 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 GTF2B 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 BECN1 21167304 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2A1 SPI1 20200559 23180781 physical association anti tag coimmunoprecipitation InnateDB
BAK1 BCL2A1 23180781 25416956 physical association two hybrid InnateDB
BCL2A1 BIK 23180781 25416956 physical association two hybrid InnateDB
BCL2A1 FAM9B 23180781 25416956 physical association two hybrid InnateDB
BCL2A1 BMF 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 BCL2A1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFKB1 BCL2A1 10733571 11880364 12665576 15592513 17000776 19343319 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
RELA BCL2A1 10733571 11880364 15592513 17000776 19343319 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 BCL2A1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 BCL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BCL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BCL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BCL2A1 18971253 23447565 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BCL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BCL2A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 BCL2A1 17000776 trascriptional regulation,stimulation inferred by curator TFlink
REL BCL2A1 11880364 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 BCL2A1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001EFBE3 BCL2A1 18057241 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 BCL2A1 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
BIK BCL2A1 25361965 interaction type N/A PTMCode2
BCL2A1 BIK 25361965 interaction type N/A PTMCode2
BCL2A1 BAX 25361965 interaction type N/A PTMCode2
BAX BCL2A1 25361965 interaction type N/A PTMCode2
BCL2A1 BAD 25361965 interaction type N/A PTMCode2
BAD BCL2A1 25361965 interaction type N/A PTMCode2
BCL2A1 BCL2L11 25361965 interaction type N/A PTMCode2
BCL2L11 BCL2A1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BCL2L11 BCL2A1 14525934 16697956 24234451 25348397 physical association experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
HAT1 BCL2A1 25348397 N/A physical interaction ComPPI
BIK BCL2A1 10381646 14525934 24234451 25348397 25416956 physical association experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
BAD BCL2A1 10381646 11483855 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GRB2 BCL2A1 14525934 25348397 27898060 9670936 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
SLC9A3R1 BCL2A1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
NR4A1 BCL2A1 14525934 18835031 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
BCL2A1 BAX 10753914 14525934 14766748 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
BCL2A1 BAK1 10381646 14525934 24234451 25348397 25416956 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
BCL2A1 BOK 14525934 25348397 9356461 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BCL2A1 PMAIP1 14525934 15694340 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2A1 BBC3 16697956 24234451 25348397 N/A fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,IntAct
BCL2A1 HRK 14525934 15694340 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2A1 BMF 25348397 N/A physical interaction ComPPI
BCL2A1 BID 11929871 14525934 16697956 24234451 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction ComPPI,HPRD,IntAct
BCL2A1 APP 25348397 N/A physical interaction ComPPI
BCL2A1 FAM9B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2A1 BBC3 14525934 15694340 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL2A1 RTL10 23055042 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BCL2A1 CT45A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BECN1 BCL2A1 21167304 27898060 N/A N/A OmniPath
BBC3 BCL2A1 15694340 27898060 inhibition N/A OmniPath
PMAIP1 BCL2A1 15694340 27898060 inhibition N/A OmniPath
BCL2L11 BCL2A1 10198631 15694340 16697956 27898060 9731710 inhibition N/A OmniPath

Visualization










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