GENE：NKX3-1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NKX3-1 |
| FullNmae | NK3 homeobox 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7838 |
| EnsembleID | ENSG00000167034 |
| Uniprot | Q99801 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NKX3-1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NKX3-1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NKX3-1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NKX3-1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NKX3-1 | GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001656,GO:0001756,GO:0001934,GO:0003700,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0006915,GO:0006919,GO:0006974,GO:0007431,GO:0007507,GO:0008284,GO:0008285,GO:0008584,GO:0008656,GO:0010628,GO:0010628,GO:0010629,GO:0030154,GO:0030331,GO:0030521,GO:0032880,GO:0033574,GO:0035907,GO:0042826,GO:0043280,GO:0043491,GO:0043565,GO:0043569,GO:0043621,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045931,GO:0045944,GO:0048754,GO:0050680,GO:0051781,GO:0051897,GO:0060037,GO:0060442,GO:0060664,GO:0060767,GO:0060770,GO:0071347,GO:0071356,GO:0071383,GO:0071456,GO:0071466,GO:0090734,GO:0097162,GO:0140297,GO:0140416,GO:1990837,GO:2000836,GO:2001235,GO:2001244 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NKX3-1 | hsa:4824 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| NKX3-1 | hsa:4824 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | NKX3-1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | NKX3-1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | NKX3-1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | NKX3-1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | NKX3-1 | 11238180 16697957 17303007 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | NKX3-1 | 20842667 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MSX2 | NKX3-1 | 22848398 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PITX1 | NKX3-1 | 21425961 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SOX4 | NKX3-1 | 20019190 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | NKX3-1 | 17202838 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | NKX3-1 | 24282594 25416803 | mrna cleavage,inhibition | western blot | TarBase |
| URS00000F31F4 | NKX3-1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | NKX3-1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000328C0D | NKX3-1 | 25416803 26313654 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK2A2 | NKX3-1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| ATM | NKX3-1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PRKCA | NKX3-1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PIM1 | NKX3-1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| SRF | NKX3-1 | 25361965 | interaction type | N/A | PTMCode2 |
| NKX3-1 | SRF | 25361965 | interaction type | N/A | PTMCode2 |
| TOP1 | NKX3-1 | 25361965 | interaction type | N/A | PTMCode2 |
| NKX3-1 | TOP1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RHOXF2 | NKX3-1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| RPL37A | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| SP4 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| EHMT2 | NKX3-1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI |
| TEX264 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| SP1 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| KAT2B | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| SRF | NKX3-1 | 10993896 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| CKAP4 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90B1 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| PEBP1 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| CHPF | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| SP3 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| MNAT1 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| MAN2B1 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| TOPORS | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| WDR77 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| TPT1 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| CCT7 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | NKX3-1 | 25348397 | N/A | physical interaction,tandem affinity purification | ComPPI |
| SP2 | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| HIPK2 | NKX3-1 | 10559189 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NR3C1 | NKX3-1 | 25348397 | N/A | physical interaction,tandem affinity purification | ComPPI |
| RNF4 | NKX3-1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HMG20B | NKX3-1 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | SPDEF | 11809674 14525934 18816836 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| NKX3-1 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | SP5 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | TOP1 | 17234752 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,pull down,physical interaction,confocal microscopy,tandem affinity purification | ComPPI,IntAct,OmniPath |
| NKX3-1 | HNRNPA0 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | AEN | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | LMCD1 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | FEM1B | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | RABL6 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | MT-ND4 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | PTMS | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | CENPX | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | RARG | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | RPSA | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | STMN3 | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | FAM136A | 25348397 | N/A | physical interaction | ComPPI |
| NKX3-1 | EHMT1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| NKX3-1 | POLR2B | 25348397 | N/A | physical interaction,tandem affinity purification | ComPPI |
| NKX3-1 | SENP5 | 25348397 | N/A | physical interaction,tandem affinity purification | ComPPI |
| NKX3-1 | ZNF655 | 25348397 | N/A | physical interaction,tandem affinity purification | ComPPI |
| NKX3-1 | ELAVL1 | 25348397 | N/A | physical interaction,tandem affinity purification | ComPPI |
| NKX3-1 | ZNF417 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKX3-1 | CD200R1L | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKX3-1 | SLC22A18 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PRKCA | NKX3-1 | 11980664 27898060 | stimulant | N/A | OmniPath |
| ATM | NKX3-1 | 23890999 27898060 | N/A | N/A | OmniPath |
| NKX3-1 | TP53 | 16697957 27898060 | stimulant | N/A | OmniPath |
| NKX3-1 | HDAC1 | 16697957 27898060 | inhibition | N/A | OmniPath |
| AR | NKX3-1 | 27898060 8943214 | stimulant | N/A | OmniPath |
| CSNK2A2 | NKX3-1 | 16581776 23129228 27898060 | stimulant | N/A | OmniPath |