Gene Information gene info

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GENE：BRIP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BRIP1
FullNmae BRCA1 interacting helicase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20473
EnsembleID ENSG00000136492
Uniprot Q9BX63

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BRIP1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRIP1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BRIP1 GO:0000077,GO:0003677,GO:0003678,GO:0003678,GO:0003682,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006281,GO:0006289,GO:0006302,GO:0006357,GO:0007284,GO:0007286,GO:0008285,GO:0009636,GO:0010629,GO:0010705,GO:0016887,GO:0031965,GO:0032508,GO:0035825,GO:0043139,GO:0046872,GO:0051026,GO:0051539,GO:0070532,GO:0071295,GO:0071456,GO:0072520,GO:1904385,GO:1990918

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BRIP1 hsa:83990 path:hsa03440 Homologous recombination - Homo sapiens (human)
BRIP1 hsa:83990 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BRIP1 CREB1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 BRIP1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 BRIP1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BRIP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BRIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 BRIP1 14576433 trascriptional regulation,stimulation inferred by curator TFlink
FOXM1 BRIP1 23108394 trascriptional regulation,stimulation inferred by curator TFlink
GATA1 BRIP1 16492768 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 BRIP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 BRIP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000451A1 BRIP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC379 BRIP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000027352D BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001496AE BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000077AED BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC4BD BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB14 BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C BRIP1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BRIP1 BRCA1 25361965 interaction type N/A PTMCode2
BRCA1 BRIP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPC BRIP1 25348397 N/A physical interaction ComPPI
FHL3 BRIP1 25348397 N/A physical interaction ComPPI
LMNA BRIP1 25348397 N/A physical interaction ComPPI
HSD17B14 BRIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPA1 BRIP1 25348397 N/A physical interaction ComPPI
FANCD2 BRIP1 25348397 N/A physical interaction ComPPI
BLM BRIP1 21240188 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,enzyme linked immunosorbent assay,fluorescence microscopy ComPPI,IntAct
SPTA1 BRIP1 25348397 N/A physical interaction ComPPI
VAPB BRIP1 25348397 N/A physical interaction ComPPI
MMS19 BRIP1 25348397 N/A physical interaction ComPPI
CDK8 BRIP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H3C1 BRIP1 25348397 N/A physical interaction ComPPI
BARD1 BRIP1 25348397 N/A physical interaction ComPPI
RAD51D BRIP1 25348397 N/A physical interaction ComPPI
MRE11 BRIP1 25348397 N/A physical interaction ComPPI
NBN BRIP1 25348397 N/A physical interaction ComPPI
RAD50 BRIP1 25348397 N/A physical interaction ComPPI
BRCA1 BRIP1 14576432 17525340 17581638 19369211 21240188 22792074 24234451 25348397 29656893 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,molecular sieving,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo,confocal microscopy,tandem affinity purification,surface plasmon resonance array,proximity-dependent biotin identification ComPPI,IntAct
MLH1 BRIP1 17581638 22792074 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,enzyme linked immunosorbent assay ComPPI,IntAct
BRIP1 PMS1 25348397 N/A physical interaction ComPPI
BRIP1 PMS2 17581638 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BRIP1 PMS2CL 25348397 N/A physical interaction ComPPI
BRIP1 TOPBP1 25348397 N/A physical interaction ComPPI
BRIP1 POMK 25348397 N/A physical interaction ComPPI
BRIP1 GFOD1 25348397 N/A physical interaction ComPPI
BRIP1 CARNMT1 25348397 N/A physical interaction ComPPI
BRIP1 LIPH 25348397 N/A physical interaction ComPPI
BRIP1 USP37 25348397 N/A physical interaction ComPPI
BRIP1 CBX3 25348397 N/A physical interaction ComPPI
BRIP1 IL17RA 25348397 N/A physical interaction ComPPI
BRIP1 LYPD4 25348397 N/A physical interaction ComPPI
BRIP1 NCAPH2 25348397 N/A physical interaction ComPPI
BRIP1 TULP2 25348397 N/A physical interaction ComPPI
BRIP1 CRTAC1 25348397 N/A physical interaction ComPPI
BRIP1 GATD1 25348397 N/A physical interaction ComPPI
BRIP1 DOCK5 25348397 N/A physical interaction ComPPI
BRIP1 AVIL 25348397 N/A physical interaction ComPPI
BRIP1 VWA5A 25348397 N/A physical interaction ComPPI
BRIP1 CRYL1 25348397 N/A physical interaction ComPPI
BRIP1 BRIP1 25348397 N/A physical interaction ComPPI
BRIP1 PALB2 19369211 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BRIP1 ABRAXAS1 17525340 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
IRF1 BRIP1 19129219 27898060 stimulant N/A OmniPath
MAFG BRIP1 21812759 27898060 N/A N/A OmniPath
RPA1 BRIP1 17596542 19419957 20159562 27898060 stimulant N/A OmniPath
MAPK3 BRIP1 15125843 27898060 N/A N/A OmniPath

Visualization










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