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GENE：F2RL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol F2RL1
FullNmae F2R like trypsin receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3538
EnsembleID ENSG00000164251
Uniprot P55085

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
F2RL1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
F2RL1 GO:0001965,GO:0002020,GO:0002286,GO:0002690,GO:0002720,GO:0003104,GO:0004930,GO:0004930,GO:0004930,GO:0005102,GO:0005515,GO:0005769,GO:0005794,GO:0005886,GO:0005886,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0007204,GO:0007596,GO:0010804,GO:0015057,GO:0030193,GO:0030335,GO:0030836,GO:0031143,GO:0031274,GO:0031681,GO:0032682,GO:0032722,GO:0032729,GO:0032731,GO:0032733,GO:0032755,GO:0032757,GO:0032930,GO:0034137,GO:0034140,GO:0034141,GO:0034145,GO:0035025,GO:0035025,GO:0035025,GO:0038023,GO:0042119,GO:0042311,GO:0043122,GO:0043123,GO:0043311,GO:0043547,GO:0045087,GO:0045217,GO:0045944,GO:0046328,GO:0046329,GO:0046330,GO:0046676,GO:0050900,GO:0050921,GO:0050927,GO:0051607,GO:0051897,GO:0060100,GO:0061028,GO:0070374,GO:0070374,GO:0070493,GO:0070661,GO:0070963,GO:0097029,GO:0097029,GO:0099109,GO:1900135,GO:2000341

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
F2RL1 hsa:2150 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
F2RL1 hsa:2150 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
F2RL1 hsa:2150 path:hsa05143 African trypanosomiasis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
F2RL1 TLR4 18622013 23180781 physical association anti tag coimmunoprecipitation InnateDB
F2RL1 GPRASP1 15452121 23180781 physical association pull down InnateDB
GPRASP1 F2RL1 15452121 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 F2RL1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 F2RL1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 F2RL1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 F2RL1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 F2RL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004719AB F2RL1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 F2RL1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F F2RL1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 F2RL1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 F2RL1 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 F2RL1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 F2RL1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE F2RL1 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 F2RL1 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA F2RL1 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 F2RL1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F5FEE F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 F2RL1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 F2RL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC F2RL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD F2RL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B F2RL1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
F2RL1 F2 25361965 interaction type N/A PTMCode2
F2 F2RL1 25361965 interaction type N/A PTMCode2
CBL F2RL1 25361965 interaction type N/A PTMCode2
F2RL1 CBL 25361965 interaction type N/A PTMCode2
ST14 F2RL1 25361965 interaction type N/A PTMCode2
F2RL1 ST14 25361965 interaction type N/A PTMCode2
CTSG F2RL1 25361965 interaction type N/A PTMCode2
F2RL1 CTSG 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMNA F2RL1 25348397 N/A physical interaction ComPPI
CTSG F2RL1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RINT1 F2RL1 25348397 N/A physical interaction ComPPI
GEMIN6 F2RL1 25348397 N/A physical interaction ComPPI
CBL F2RL1 14525934 15708858 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vivo,confocal microscopy ComPPI,HPRD,IntAct,OmniPath
COPS5 F2RL1 14525934 16410250 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
ELANE F2RL1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PLG F2RL1 10978167 12604689 14525934 25348397 9020112 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
F2 F2RL1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2RL1 PRTN3 10978167 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
F2RL1 ST14 10831593 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
F2RL1 CAPN1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2RL1 CAPN2 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2RL1 GPRASP1 14525934 15452121 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F2RL1 BIRC5 25348397 N/A physical interaction ComPPI
F2RL1 MOV10 25348397 N/A physical interaction ComPPI
F2RL1 GEMIN4 25348397 N/A physical interaction ComPPI
F2RL1 ZW10 25348397 N/A physical interaction ComPPI
F2RL1 DNMT3L 25348397 N/A physical interaction ComPPI
F2RL1 HSDL2 25348397 N/A physical interaction ComPPI
F2RL1 INTS12 25348397 N/A physical interaction ComPPI
F2RL1 C19ORF25 25348397 N/A physical interaction ComPPI
F2RL1 F3 16959886 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
F2RL1 TMED2 17693410 21219331 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,confocal microscopy ComPPI,IntAct,OmniPath
F2RL1 TLR4 18622013 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
F2RL1 TMED10 21219331 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
SLMAP F2RL1 25348397 N/A physical interaction ComPPI
F2RL1 HSPA1B 24234451 28298427 physical association anti bait coimmunoprecipitation,ubiquitin reconstruction IntAct
F2RL1 ATP2A2 24234451 28298427 physical association anti bait coimmunoprecipitation,ubiquitin reconstruction IntAct
F2RL1 PRNP 24234451 28298427 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
F2RL1 ABHD14A 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ADCY2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ARL6IP1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ABCC8 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ATP2B1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ATP2C1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 BSG 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CANX 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CAPNS1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 NAT14 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 HLA-E 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 KLC1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 KDELR1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ICAM2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 P4HTM 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 HERPUD1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CNN3 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CRLS1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CTNNA1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CD63 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CD81 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 MORN4 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC18B1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 NBPF15 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC12A5 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC1A4 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SCN1B 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 RGR 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 RTN4 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 RTN1 24234451 28298427 physical association ubiquitin reconstruction IntAct
R3HDM1 F2RL1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 HMOX2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 QSER1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 GJC2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 GJB6 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 ERGIC3 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 OSTC 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 CLPTM1 24234451 28298427 physical association ubiquitin reconstruction IntAct
SLC32A1 F2RL1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SDHD 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SYNGR2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 MFSD10 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC35A1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 TMBIM1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 TMED1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 TMEM161A 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 TMEM62 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 PSMC3 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 PRRT2 24234451 28298427 physical association ubiquitin reconstruction IntAct
PHLDA1 F2RL1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 PTDSS2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 PIGU 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC31A2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC39A13 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 SLC43A2 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 WFS1 24234451 28298427 physical association ubiquitin reconstruction IntAct
TMX2 F2RL1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 PPM1J 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 YIPF6 24234451 28298427 physical association ubiquitin reconstruction IntAct
YIPF1 F2RL1 24234451 28298427 physical association ubiquitin reconstruction IntAct
F2RL1 GNAQ 27898060 9349532 stimulant N/A OmniPath
ARRB1 F2RL1 10725339 27898060 inhibition N/A OmniPath
F2RL1 TLR4 18622013 27898060 N/A N/A OmniPath
PRSS1 F2RL1 27898060 9349532 stimulant N/A OmniPath
F2 F2RL1 10978167 11356985 27898060 stimulant N/A OmniPath
PLG F2RL1 10978167 12604689 27898060 9020112 stimulant N/A OmniPath

Visualization










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