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GENE：GTF2H1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GTF2H1
FullNmae general transcription factor IIH subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4655
EnsembleID ENSG00000110768
Uniprot P32780

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GTF2H1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GTF2H1 GO:0000079,GO:0000439,GO:0000439,GO:0003682,GO:0005515,GO:0005654,GO:0005654,GO:0005675,GO:0005675,GO:0006281,GO:0006289,GO:0006360,GO:0006366,GO:0006366,GO:0009755,GO:0045893,GO:0046966

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GTF2H1 hsa:2965 path:hsa03022 Basal transcription factors - Homo sapiens (human)
GTF2H1 hsa:2965 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
GTF2H1 hsa:2965 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 GTF2H1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GTF2H1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A GTF2H1 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 GTF2H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GTF2H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GTF2H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GTF2H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GTF2H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GTF2H1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171CD1 GTF2H1 18362358 rna interference,inhibition array technology miRSponge
URS0000171CD1 GTF2H1 18362358 25416803 mrna cleavage,inhibition array technology TarBase
URS0000028BB8 GTF2H1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 GTF2H1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001A405B GTF2H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 GTF2H1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CF056 GTF2H1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 GTF2H1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000077AED GTF2H1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB GTF2H1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 GTF2H1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F GTF2H1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 GTF2H1 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F5FEE GTF2H1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005E6F45 GTF2H1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CCNH GTF2H1 10734143 14525934 24234451 25348397 26340423 7533895 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
KPNA3 GTF2H1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LZTS2 GTF2H1 25348397 N/A physical interaction ComPPI
TP53BP1 GTF2H1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
ERCC3 GTF2H1 14525934 24234451 25348397 26340423 8194528 8652557 9118947 9130708 9173976 association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MCM2 GTF2H1 12392551 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TNIP1 GTF2H1 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
PIK3R1 GTF2H1 10467411 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RB1 GTF2H1 25348397 N/A physical interaction ComPPI
AR GTF2H1 10734072 11266437 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JDP2 GTF2H1 25348397 N/A physical interaction ComPPI
GTF2H1 GTF2E1 11113176 14525934 18160537 18354501 24234451 25348397 physical association experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,pull down,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
GTF2H1 GTF2E2 12665589 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GTF2H1 E2F1 10428966 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2H1 XPC 10734143 11259578 14525934 24234451 25348397 N/A experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
GTF2H1 HNRNPU 10490622 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GTF2H1 KIF13A 10777215 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GTF2H1 FUBP1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
GTF2H1 CDK7 14525934 23602568 24234451 25348397 26340423 29568061 9130708 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
GTF2H1 MMS19 11071939 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2H1 GTF2H2 14525934 21988832 24234451 25348397 8652557 9130708 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
GTF2H1 CCSER2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GTF2H1 ERCC2 14525934 24234451 25348397 26340423 8652557 9130708 association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
GTF2H1 ESR1 10949034 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2H1 ERCC4 11259578 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2H1 ERCC5 11259578 14525934 25348397 8652557 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2H1 PSMC2 11118327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GTF2H1 TCEA1 25348397 N/A physical interaction ComPPI
GTF2H1 TP53 14525934 16793543 18160537 18354501 24234451 25348397 27898060 7935417 8612585 N/A experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct,OmniPath
GTF2H1 POU2AF1 25348397 N/A physical interaction ComPPI
GTF2H1 ZSCAN1 25348397 N/A physical interaction ComPPI
GTF2H1 RXRB 25348397 N/A physical interaction ComPPI
GTF2H1 MNAT1 24234451 25348397 26340423 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2H1 ERCC1 25348397 N/A physical interaction ComPPI
GTF2H1 RPA2 25348397 N/A physical interaction ComPPI
GTF2H1 RAD23B 25348397 N/A physical interaction ComPPI
GTF2H1 UBC 25348397 N/A physical interaction ComPPI
GTF2H1 RAD23A 25348397 N/A physical interaction ComPPI
GTF2H1 POLR2A 25348397 N/A physical interaction ComPPI
GTF2H1 GTF2F1 25348397 N/A physical interaction ComPPI
GTF2H1 POLR2C 18562274 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2H1 HNF4A 25348397 N/A physical interaction ComPPI
GTF2H1 KLF1 21670263 24234451 25348397 N/A isothermal titration calorimetry,nuclear magnetic resonance,physical interaction ComPPI,IntAct
GTF2H1 RNF11 25348397 N/A physical interaction ComPPI
GTF2H1 USHBP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GTF2H1 ACTN1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GTF2H1 GTF2H5 19172752 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF2H1 NUDC 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
GTF2H1 TRIM25 25348397 N/A physical interaction ComPPI
RPA1 GTF2H1 25348397 N/A physical interaction ComPPI
XPA GTF2H1 14525934 25348397 9698541 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GTF2H1 PLCG1 10467411 14525934 N/A experimental interaction detection HPRD
ATF7IP GTF2H1 10777215 14525934 N/A experimental interaction detection HPRD
GTF2H1 E2F1 10428966 27898060 9400991 N/A N/A OmniPath

Visualization










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