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GENE：BCL2L2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BCL2L2
FullNmae BCL2 like 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:995
EnsembleID ENSG00000129473
Uniprot Q92843

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BCL2L2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BCL2L2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BCL2L2 GO:0002931,GO:0005515,GO:0005741,GO:0005829,GO:0007283,GO:0008630,GO:0035795,GO:0042802,GO:0042803,GO:0042981,GO:0043066,GO:0044877,GO:0046982,GO:0051400,GO:0060011,GO:0071392,GO:0090201,GO:0097136,GO:0097136,GO:0097192,GO:0097718,GO:1904646,GO:1905430,GO:2001243

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BCL2L2 hsa:599 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BAK1 BCL2L2 23180781 25416956 physical association two hybrid InnateDB
BCL2L2 BIK 23180781 25416956 physical association two hybrid InnateDB
BCL2L2 TCF4 23180781 25416956 physical association two hybrid InnateDB
BCL2L2 FATE1 23180781 25416956 physical association two hybrid InnateDB
BCL2L2 BMF 23180781 25416956 physical association two hybrid InnateDB
BCL2L2 KASH5 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 BCL2L2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A BCL2L2 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 BCL2L2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF BCL2L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BCL2L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BCL2L2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC BCL2L2 18692484 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000032BD73 BCL2L2 19654003 20056941 \N rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000040EE1D BCL2L2 23526568 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB BCL2L2 21205209 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 BCL2L2 21282569 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000160683 BCL2L2 23337879 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003380CC BCL2L2 18692484 22743998 24121065 25416803 27415790 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000032BD73 BCL2L2 18927107 19654003 20056941 22743998 24391788 25414595 25416803 27802259 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS000041CB9C BCL2L2 19956871 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS00004DA9DB BCL2L2 21205209 24219989 25416803 26599571 27142767 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 BCL2L2 21282569 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 BCL2L2 21822301 23740614 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000160683 BCL2L2 23337879 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000040EE1D BCL2L2 23526568 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000002103A BCL2L2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 BCL2L2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 BCL2L2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 BCL2L2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 BCL2L2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 BCL2L2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 BCL2L2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 BCL2L2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000048F59D BCL2L2 25416803 26935022 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
BIK BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 BIK 25361965 interaction type N/A PTMCode2
BCL2L2 BAX 25361965 interaction type N/A PTMCode2
BAX BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 BAD 25361965 interaction type N/A PTMCode2
BAD BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 BID 25361965 interaction type N/A PTMCode2
BID BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 PPP1CA 25361965 interaction type N/A PTMCode2
PPP1CA BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 PMAIP1 25361965 interaction type N/A PTMCode2
PMAIP1 BCL2L2 25361965 interaction type N/A PTMCode2
BCL2L2 BCL2L11 25361965 interaction type N/A PTMCode2
BCL2L11 BCL2L2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BCL2L11 BCL2L2 14525934 15694340 16697956 17289999 21199865 24234451 25348397 9430630 9731710 physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,two hybrid array,in vitro,in vivo,surface plasmon resonance array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
S100B BCL2L2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
LMNA BCL2L2 25348397 N/A physical interaction ComPPI
BCL2L2 BIK 14525934 15694340 16697956 24234451 25348397 25416956 27107012 physical association two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,two hybrid array,in vitro,surface plasmon resonance array,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
BCL2L2 KASH5 24234451 25348397 25416956 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
BCL2L2 FATE1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2L2 BAD 11483855 12115603 14525934 15694340 22000515 24234451 25348397 physical association experimental interaction detection,isothermal titration calorimetry,surface plasmon resonance,physical interaction,two hybrid array,in vitro,in vivo,surface plasmon resonance array,two hybrid prey pooling approach ComPPI,HPRD,IntAct
BCL2L2 BMF 11546872 14525934 24234451 25348397 25416956 physical association experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
BCL2L2 PPP1CA 12115603 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCL2L2 HRK 14525934 15694340 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
BCL2L2 BBC3 15694340 16697956 24234451 25348397 N/A fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,IntAct
BCL2L2 BID 14525934 15694340 16697956 17289999 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
BCL2L2 BAX 17289999 18981409 21199865 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2L2 BAK1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2L2 ELAVL1 25348397 N/A physical interaction ComPPI
BCL2L2 TP53 25348397 N/A physical interaction ComPPI
BCL2L2 PRKN 25348397 N/A physical interaction ComPPI
BCL2L2 PINK1 25348397 N/A physical interaction ComPPI
BCL2L2 TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2L2 THOC7 25348397 N/A physical interaction ComPPI
BCL2L2 THOC2 25348397 N/A physical interaction ComPPI
BCL2L2 CDH1 25348397 N/A physical interaction ComPPI
BCL2L2 BBC3 14525934 15694340 16697956 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BCL2L2 SLC27A2 25348397 N/A physical interaction ComPPI
BCL2L2 NKAPD1 25348397 N/A physical interaction ComPPI
BCL2L2 TP53BP2 18448430 18719108 24234451 25348397 N/A peptide array,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
BCL2L2 PMAIP1 15694340 24234451 25348397 N/A anti tag coimmunoprecipitation,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
BCL2L2 GABARAPL2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BCL2L2 RTL10 23055042 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
BCL2L2 SAR1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 TMEM139 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 CISD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 SLC35E3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 GORAB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 MGST2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 CIDEB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 PANX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 ERVFRD-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 CLDN7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 SLC39A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 CD79A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 TMX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 SUSD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 BNIP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 KCNJ6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 CHODL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 GPR151 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 BHLHA9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 STOM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 APOC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL2L2 BCL2L2 22000515 24234451 N/A cosedimentation in solution,molecular sieving,x-ray crystallography IntAct
BID BCL2L2 15694340 16697956 27898060 inhibition N/A OmniPath
BMF BCL2L2 11546872 25416956 27898060 inhibition,stimulant N/A OmniPath
BAD BCL2L2 10381646 11483855 12115603 15694340 16697956 20603619 22000515 27898060 inhibition N/A OmniPath
BCL2L2 BAK1 10381646 15901672 17289999 18178565 25416956 27898060 inhibition N/A OmniPath
BBC3 BCL2L2 15694340 27898060 inhibition N/A OmniPath
BCL2L11 BCL2L2 15694340 16697956 27898060 9430630 9731710 inhibition N/A OmniPath
BCL2L2 BIK 10381646 15694340 16697956 25416956 27898060 inhibition N/A OmniPath
BCL2L2 BAX 17289999 17452531 18178565 21199865 27898060 inhibition N/A OmniPath
BBC3 BCL2L2 15694340 16697956 27898060 inhibition N/A OmniPath

Visualization










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