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GENE：KDM2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KDM2A
FullNmae lysine demethylase 2A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13606
EnsembleID ENSG00000173120
Uniprot Q9Y2K7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KDM2A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KDM2A GO:0003712,GO:0005515,GO:0005654,GO:0005654,GO:0005694,GO:0006303,GO:0006338,GO:0006357,GO:0006482,GO:0008270,GO:0010944,GO:0032452,GO:0032452,GO:0032922,GO:0042752,GO:0045322,GO:0051864,GO:0140680

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KDM2A hsa:22992 path:hsa03083 Polycomb repressive complex - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EED KDM2A 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
KDM2A ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR KDM2A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 KDM2A 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 KDM2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 KDM2A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 KDM2A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR KDM2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 KDM2A 20080798 trascriptional regulation,stimulation inferred by curator TFlink
RELA KDM2A 20080798 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB KDM2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 KDM2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F KDM2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 KDM2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E3523 KDM2A 25416803 26461474 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237CBD KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000600E6 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C85C7 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002152A8 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000137EDE KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032AE90 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000053B1E8 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075A760 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000759FD9 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006097A6 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C36BD KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BEA7 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E5ECC KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001FA076 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C1E1 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005E1A16 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 KDM2A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000812128 KDM2A 24297251 direct interaction,inhibition high throughput sequencing StarBase

Source Target Pmid Interactiontype Methods Database
CDK2 KDM2A 22135298 phosphorylation N/A PhosphoSite
ATM KDM2A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PPP1R2B KDM2A 25348397 N/A physical interaction ComPPI
SKP1 KDM2A 15070733 24234451 25348397 27705803 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
H2BC4 KDM2A 25348397 N/A physical interaction ComPPI
ZNF512B KDM2A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD7 KDM2A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RB1 KDM2A 25348397 N/A physical interaction ComPPI
SMAD3 KDM2A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UBE2G2 KDM2A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ENO1 KDM2A 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
E2F1 KDM2A 25348397 N/A physical interaction ComPPI
HNRNPL KDM2A 25348397 N/A physical interaction ComPPI
UHRF2 KDM2A 25348397 N/A physical interaction ComPPI
RELA KDM2A 20080798 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATM KDM2A 25348397 N/A physical interaction ComPPI
CBX4 KDM2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 KDM2A 25348397 N/A physical interaction ComPPI
H3-4 KDM2A 25348397 N/A physical interaction ComPPI
H3C15 KDM2A 14525934 16362057 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
EED KDM2A 25348397 N/A physical interaction ComPPI
ARHGEF7 KDM2A 25348397 N/A physical interaction ComPPI
TRIM25 KDM2A 25348397 N/A physical interaction ComPPI
ELAVL1 KDM2A 25348397 N/A physical interaction ComPPI
KIF20B KDM2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP1R2 KDM2A 25348397 N/A physical interaction ComPPI
PSMB3 KDM2A 25348397 N/A physical interaction ComPPI
RAB5C KDM2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAG2 KDM2A 25348397 N/A physical interaction ComPPI
ACTR1B KDM2A 25348397 N/A physical interaction ComPPI
MPG KDM2A 25348397 N/A physical interaction ComPPI
RBPJ KDM2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
KDM2A FOS 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
KDM2A BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KDM2A H2BC11 25348397 N/A physical interaction ComPPI
KDM2A REEP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KDM2A CGB2 25348397 N/A physical interaction ComPPI
KDM2A FBXO32 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ECPAS KDM2A 25348397 N/A physical interaction ComPPI
ATM KDM2A 25823024 27898060 N/A N/A OmniPath
KDM2A RELA 20080798 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C01D1 KDM2A 27087310 direct interaction,inhibition N/A NPInter

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