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GENE：KLF5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KLF5
FullNmae KLF transcription factor 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6349
EnsembleID ENSG00000102554
Uniprot Q13887

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KLF5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KLF5 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
KLF5 GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001525,GO:0005515,GO:0005654,GO:0005667,GO:0005794,GO:0006357,GO:0014816,GO:0014901,GO:0014908,GO:0030033,GO:0032534,GO:0043231,GO:0043426,GO:0045600,GO:0045944,GO:0046872,GO:0060576,GO:0061586,GO:0099156,GO:1902895,GO:1990830,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KLF5 hsa:688 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD4 KLF5 19419955 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MYC KLF5 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 KLF5 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF5 ZBTB17 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 KLF5 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF5 CDKN2B 19419955 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD2 KLF5 18729074 23180781 physical association tandem affinity purification InnateDB
KLF5 EGR1 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF5 PPARG 23180781 25686501 physical association anti tag coimmunoprecipitation InnateDB
KLF5 PPARA 23180781 25686501 physical association anti tag coimmunoprecipitation InnateDB
KLF5 PPARD 23180781 25686501 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR KLF5 19460858 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 KLF5 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 KLF5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 KLF5 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 KLF5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 KLF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMURF2 KLF5 21953463 trascriptional regulation,stimulation inferred by curator TFlink
RARA KLF5 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB KLF5 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARG KLF5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 KLF5 N/A 15131085 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 KLF5 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004F4657 KLF5 18927107 19542014 23128394 25273883 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000003E1A9 KLF5 15131085 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS000009262D KLF5 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000008A99 KLF5 23128394 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009C45F KLF5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF KLF5 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B KLF5 22135298 phosphorylation N/A PhosphoSite
WWP1 KLF5 25361965 interaction type N/A PTMCode2
KLF5 WWP1 25361965 interaction type N/A PTMCode2
SET KLF5 25361965 interaction type N/A PTMCode2
KLF5 SET 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I KLF5 25348397 N/A physical interaction ComPPI
ANP32B KLF5 18039846 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RARA KLF5 12101409 14525934 16102021 16224062 18466769 21383775 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
CEBPG KLF5 25348397 N/A physical interaction ComPPI
SET KLF5 14525934 14612398 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 KLF5 25348397 N/A physical interaction ComPPI
GTF2B KLF5 25348397 N/A physical interaction ComPPI
SMURF2 KLF5 21953463 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TBP KLF5 25348397 N/A physical interaction ComPPI
PRKCA KLF5 25348397 N/A physical interaction ComPPI
FBXW7 KLF5 25348397 N/A physical interaction ComPPI
PRKCD KLF5 12682370 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
JUN KLF5 25348397 N/A physical interaction ComPPI
GTF2F2 KLF5 14525934 25348397 9089417 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HCFC1 KLF5 25348397 N/A physical interaction ComPPI
CREBBP KLF5 12682370 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD2 KLF5 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
SUMO1 KLF5 25348397 N/A physical interaction ComPPI
EP300 KLF5 14525934 14612398 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 KLF5 25348397 N/A physical interaction ComPPI
CEBPB KLF5 25348397 N/A physical interaction ComPPI
WWP1 KLF5 16223724 20694673 21487105 22045023 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GSK3B KLF5 25348397 N/A physical interaction ComPPI
NCOR2 KLF5 25348397 N/A physical interaction ComPPI
NCOR1 KLF5 25348397 N/A physical interaction ComPPI
UBC KLF5 17320083 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PARP1 KLF5 17283079 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RRBP1 KLF5 25348397 N/A physical interaction ComPPI
SREBF1 KLF5 25348397 N/A physical interaction ComPPI
PPARG KLF5 25348397 N/A physical interaction ComPPI
KLF5 GTF2E2 14525934 25348397 9089417 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
KLF5 NFKB1 14525934 14573617 16102021 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
KLF5 ESR1 25348397 N/A physical interaction ComPPI
KLF5 HDAC1 25348397 N/A physical interaction ComPPI
KLF5 HDAC2 25348397 N/A physical interaction ComPPI
KLF5 TRIM25 21542805 22452784 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KLF5 ESR2 25348397 N/A physical interaction ComPPI
KLF5 WWTR1 25348397 N/A physical interaction ComPPI
KLF5 ELAVL1 25348397 N/A physical interaction ComPPI
KLF5 YAP1 25348397 N/A physical interaction ComPPI
KLF5 ZBTB17 25348397 N/A physical interaction ComPPI
KLF5 CTNNB1 25348397 N/A physical interaction ComPPI
KLF5 TP53 25348397 N/A physical interaction ComPPI
KLF5 ATXN3L 25348397 26079537 27898060 N/A physical interaction ComPPI,OmniPath
KLF5 XPO1 25348397 N/A physical interaction ComPPI
KLF5 ACTR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLF5 RXRA 25348397 N/A physical interaction ComPPI
KLF5 CSRP3 25348397 N/A physical interaction ComPPI
KLF5 CEBPA 21821915 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KLF5 BAP1 25348397 N/A physical interaction ComPPI
KLF5 OGT 25348397 N/A physical interaction ComPPI
KLF5 ACTA2 25348397 N/A physical interaction ComPPI
PRKCD KLF5 12682370 27898060 stimulant N/A OmniPath
MYC KLF5 19419955 27898060 N/A N/A OmniPath
EP300 KLF5 14612398 15668237 16102021 19419955 27898060 N/A N/A OmniPath
KLF5 EP300 14612398 15668237 16102021 19419955 27898060 N/A N/A OmniPath
GSK3B KLF5 20388706 20484041 24398687 27898060 inhibition N/A OmniPath
PTK6 KLF5 12682370 27898060 N/A N/A OmniPath

Visualization










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