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GENE：PIM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIM1
FullNmae Pim-1 proto-oncogene, serine/threonine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8986
EnsembleID ENSG00000137193
Uniprot P11309

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIM1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIM1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PIM1 GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0008134,GO:0022898,GO:0030145,GO:0043024,GO:0043066,GO:0043433,GO:0045893,GO:0046777,GO:0046777,GO:0050821,GO:0060045,GO:0070561,GO:0090336,GO:0106310,GO:1902033,GO:1904263,GO:1905062,GO:1990748

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIM1 hsa:5292 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIM1 hsa:5292 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PIM1 hsa:5292 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PIM1 hsa:5292 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PIM1 hsa:5292 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AKT1S1 PIM1 19276681 23180781 phosphorylation reaction protein kinase assay InnateDB
ERG PIM1 23180781 25906745 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PIM1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PIM1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 PIM1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 PIM1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 PIM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PIM1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PIM1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PIM1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PIM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PIM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ABL1 PIM1 15145216 trascriptional regulation,stimulation inferred by curator TFlink
ERG PIM1 22140532 trascriptional regulation,stimulation inferred by curator TFlink
KCNH2 PIM1 22140532 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 PIM1 10068671 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 PIM1 10068671 22273698 trascriptional regulation,stimulation inferred by curator TFlink
STAT4 PIM1 10068671 trascriptional regulation,stimulation inferred by curator TFlink
STAT5A PIM1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B PIM1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PIM1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 PIM1 19074876 rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000055128B PIM1 19782034 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000CBE63 PIM1 21743487 rna interference,inhibition experimental interaction detection miRSponge
URS000055128B PIM1 18927107 19782034 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000B59A2 PIM1 19074876 20371350 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,nucleotide sequence identification,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 PIM1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 PIM1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000CBE63 PIM1 21743487 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001270D3 PIM1 22983447 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171CD1 PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 PIM1 22815788 23446348 25416803 26820394 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip TarBase
URS000041CB9C PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 PIM1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004F859B PIM1 25416803 27107696 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000028C188 PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E0524 PIM1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D PIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000E1E9E PIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 PIM1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIM1 SKP2 22135298 phosphorylation N/A PhosphoSite
PIM1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
PIM1 BAD 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PIM1 CDKN1A 22135298 phosphorylation N/A PhosphoSite
PIM1 RUNX3 22135298 phosphorylation N/A PhosphoSite
PIM1 POU5F1 22135298 phosphorylation N/A PhosphoSite
PIM1 IRS1 22135298 phosphorylation N/A PhosphoSite
PIM1 MDM2 22135298 phosphorylation N/A PhosphoSite
PIM1 FOXO3 22135298 phosphorylation N/A PhosphoSite
PIM1 IRS2 22135298 phosphorylation N/A PhosphoSite
PIM1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
PIM1 HBP1 22135298 phosphorylation N/A PhosphoSite
PIM1 NKX3-1 22135298 phosphorylation N/A PhosphoSite
PIM1 H3C1 22135298 phosphorylation N/A PhosphoSite
PIM1 ABCG2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PIM1 RELA 22135298 phosphorylation N/A PhosphoSite
PIM1 AR 22135298 phosphorylation N/A PhosphoSite
PIM1 CXCR4 22135298 phosphorylation N/A PhosphoSite
PIM1 FOXP3 22135298 phosphorylation N/A PhosphoSite
STAT3 PIM1 25361965 interaction type N/A PTMCode2
PIM1 STAT3 25361965 interaction type N/A PTMCode2
SNX6 PIM1 25361965 interaction type N/A PTMCode2
PIM1 SNX6 25361965 interaction type N/A PTMCode2
BAD PIM1 25361965 interaction type N/A PTMCode2
ABCG2 PIM1 25361965 interaction type N/A PTMCode2
NUMA1 PIM1 25361965 interaction type N/A PTMCode2
PIM1 NUMA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 PIM1 25348397 N/A physical interaction ComPPI
DDX6 PIM1 25348397 N/A physical interaction ComPPI
HEXIM2 PIM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFPT PIM1 25348397 N/A physical interaction ComPPI
FXR2 PIM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN1A PIM1 12431783 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EDC3 PIM1 25348397 N/A physical interaction ComPPI
CDKN1B PIM1 25348397 N/A anti bait coimmunoprecipitation ComPPI
HSP90AB1 PIM1 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BAD PIM1 14525934 16403219 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DCP1A PIM1 25348397 N/A physical interaction ComPPI
PTPRO PIM1 11368509 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NFATC1 PIM1 11823475 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIM1 SND1 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PIM1 CBX1 12111331 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIM1 CDC25A 10373478 12411508 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIM1 SNX6 11279102 11591366 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIM1 SHMT1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIM1 EPHA3 14525934 16186805 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIM1 H3-4 14525934 17643117 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIM1 HSP90AA1 11237709 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIM1 NUMA1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PIM1 HSP90AA2P 25348397 N/A physical interaction ComPPI
PIM1 CBX3 10664448 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PIM1 H3C15 25348397 N/A physical interaction ComPPI
PIM1 MAX 25348397 N/A physical interaction ComPPI
PIM1 MYC 25348397 N/A physical interaction ComPPI
PIM1 SKP2 25348397 N/A physical interaction ComPPI
PIM1 CDC20 25348397 N/A physical interaction ComPPI
PIM1 ABCB1 20460432 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PIM1 FZR1 25348397 N/A physical interaction ComPPI
PIM1 ELAVL1 25348397 N/A physical interaction ComPPI
PIM1 MDM2 19166854 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PIM1 MARK3 25348397 N/A physical interaction ComPPI
PIM1 HSPA4 25348397 N/A physical interaction ComPPI
PIM1 APP 25348397 N/A physical interaction ComPPI
PIM1 FH 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIM1 ZBTB1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIM1 BANP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIM1 BEND7 25348397 N/A physical interaction ComPPI
PIM1 EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
PIM1 DCP1B 25348397 N/A physical interaction ComPPI
PIM1 DCAF4 25348397 N/A physical interaction ComPPI
PIM1 PPP2CA 25348397 N/A physical interaction ComPPI
PIM1 PPP2R5B 25348397 N/A physical interaction ComPPI
PIM1 STAT3 25348397 N/A anti bait coimmunoprecipitation ComPPI
PIM1 ABCG2 25348397 N/A two hybrid ComPPI
PIM1 FOXO3 25348397 N/A anti bait coimmunoprecipitation ComPPI
PIM1 RPS19 16266891 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,two hybrid,pull down,in-gel kinase assay ComPPI,IntAct
PIM1 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
BMX PIM1 16186805 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDC34 PIM1 25348397 N/A physical interaction ComPPI
NHLH1 PIM1 25348397 N/A physical interaction ComPPI
PIM1 SPI1 16371130 27898060 8387358 8887664 N/A N/A OmniPath
PIM1 CDC25A 10373478 12411508 19413330 27898060 N/A N/A OmniPath
PIM1 CDKN1A 10753973 11756412 12431783 17855660 20307683 23886938 25329316 27898060 stimulant N/A OmniPath
PIM1 AKT1S1 19276681 27898060 N/A N/A OmniPath
PIM1 FOXO3 18593906 27898060 inhibition N/A OmniPath
PIM1 CDKN1B 18593906 27898060 inhibition N/A OmniPath
PIM1 MDM2 11504915 11715018 11923280 11960368 18467333 19166854 23132866 27898060 stimulant N/A OmniPath
PIM1 BAD 10611223 10837486 10949026 10976111 11085518 11577096 11825565 12566304 12970779 14678993 14729617 15037618 15105836 15121878 15226424 15695406 15705582 15972258 16109716 16403219 16540661 16818649 17535812 17670745 18669648 18707149 19147983 19154409 19483729 19664994 19667065 20166139 20179209 21187157 21262926 21419810 21849418 22096607 24909179 26366732 26387536 27898060 9381178 9651683 inhibition N/A OmniPath
PIM1 SKP2 18239684 20663873 27898060 9858587 N/A N/A OmniPath
PIM1 H3C1 17643117 27898060 stimulant N/A OmniPath
PIM1 MAP3K5 11154276 12697749 14500571 16532036 19749799 27898060 inhibition N/A OmniPath
PIM1 AR 11156376 11404460 14555644 18332867 22155408 22584579 27898060 N/A N/A OmniPath
PIM1 RUNX3 18767071 27898060 N/A N/A OmniPath
PIM1 RELA 11027313 11931769 12230568 12628924 15516339 17991436 18178962 18362169 19911008 19933278 20364151 20504937 20562110 20639196 23100252 25557171 27898060 9660950 stimulant N/A OmniPath
STAT3 PIM1 11533249 27898060 stimulant N/A OmniPath
PIM1 FOXP3 25096571 27898060 N/A N/A OmniPath
PIM1 RPS19 16266891 27898060 stimulant N/A OmniPath
PIM1 MARK3 15319445 26186194 27898060 inhibition N/A OmniPath
PIM1 ABCG2 18056989 27898060 N/A N/A OmniPath

Visualization










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